搜索页_+Lipoxygenase+inhibitor

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在“Elsevier电子期刊”中，命中：730条，耗时：0.0179906 秒

在所有数据库中总计命中：1,005条

1.Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

作者：Isabelle V. Maucher^a ; Michael Rü ; hl^a ; Simon B.M. Kretschmer^a ; Bettina Hofmann^a ; Benjamin Kü ; hn^a ; Jasmin Fettel^a ; Anja Vogel^a ; ^b ; Karsten T. Flü ; gel^a ; Georg Manolikakes^c ; Nadine Hellmuth^a ; Ann-Kathrin Hä ; fner^a ; Vahid Golghalyani^a ; Ann-Katrin Ball^a ; Matthias Piesche^d ; ^g ; Carmela Matrone^d ; Gerd Geisslinger^b ; ^e ; Michael J. Parnham^b ; Michael Karas^a ; Dieter Steinhilber^a ; Jessica Roos^a ; ¹ ; ^{roos@pharmchem.uni-frankfurt.de} ; Thorsten J. Maier^d ; ^f ; ¹ ; ^{maier@biomed.au.dk}

关键词：AA ; arachidonic acid ; methyl-BQ ; 2 ; 5-dimethyl-1 ; 4-benzoquinone ; CDDO ; CDDO-methylester ; methoxy-BQ ; 2 ; 3-dimethoxy-5-methyl-p-benzoquinone ; methoxy-NS ; 3-methoxy-β-nitrostyrene ; DMF ; dimethyl fumarate ; GSH ; glutathione ; OH-BQ ; 2 ; 5-dihydroxy-1 ; 4-benzoquinone ; HPLC ; high-performance liquid chromatography ; H(P)ETE ; hydro (peroxy-) eicosatetraenoic acid ; LT ; leukotrienes ; MS ; mass spectrometry ; NAC ; N-acetylcysteine ; NAPQI ; N-acetyl-p-benzoquinone imine ; NEM ; N-ethylmaleimide ; NFA ; nitro-fatty acid

刊名：Biochemical Pharmacology

出版年：2017

2.Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies

作者：Aamer Saeed^a ; ^{aamersaeed@yahoo.com} ; Shafi Ullah Khan^b ; Parvez Ali Mahesar^a ; Pervaiz Ali Channar^a ; Ghulam Shabir^a ; Jamshed Iqbal^b ; ^{drjamshed@ciit.net.pk}

关键词：Thiazoles ; 15-Lipoxygenase ; Bovine carbonic anhydrase II ; Docking studies

刊名：Biochemical and Biophysical Research Communications

出版年：2017

3.Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity

作者：P.S. Yashaswini ; A.G. Appu Rao ; Sridevi A. Singh ; ^{ssingh98@yahoo.com} ; ^{sridevi@cftri.res.in}

关键词：Sesamol ; Lipoxygenase ; Inhibition studies

刊名：International Journal of Biological Macromolecules

出版年：2017

4.12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice

作者：Antonio Di Meco^a ; Jian-Guo Li^a ; Benjamin E. Blass^b ; Magid Abou-Gharbia^b ; Elisabetta Lauretti^a ; Domenico Praticò ; ^a ; ^{praticod@temple.edu}

关键词：Alzheimer&rsquo ; s disease ; Amyloid beta ; Animal model ; Autophagy ; Tau protein ; 12/15-Lipoxygenase

刊名：Biological Psychiatry

出版年：2017

5.BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

关键词：5-LO ; 5-lipoxygenase ; AA ; arachidonic acid ; COX ; cyclooxygenase ; cPLA2 ; cytosolic phospholipase A2 ; FLAP ; 5-lipoxygenase-activating protein ; fMLP ; N-formyl-methionyl-leucyl-phenylalanine ; H(P)ETE ; hydro(pero)oxyeicosatetraenoic acid ; HHT ; hydroxyheptadecatrienoic acid ; IL ; interleukin ; LPS ; lipopolysaccharide ; LT ; leukotriene ; mPGES-1 ; microsomal prostaglandin E2 synthase 1 ; MPO ; myeloperoxidase ; PG ; phosphate-buffered saline plus 1 ; mg/ml glucose ; PGC ; phosphate-buffered saline plus 1

刊名：Biochemical Pharmacology

出版年：2016

6.Tagenols A and B: New lipoxygenase inhibitor flavonols from Tagetes minuta

作者：Gamal A. Mohamed^a ; ^b ; ^{gamals2001@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Tagetes minuta ; Tagenol ; Flavonol ; Lipoxygenase inhibitor ; Antioxidant

刊名：Phytochemistry Letters

出版年：2016

7.Biological evaluation of potent antioxidant, lipoxygenase inhibitor and antibacterial: A comparative study

作者：Muhammad Aslam^a ; ^b ; ^{maslamchemist@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Itrat Anis^b ; Nighat Afza^a ; Lubna Iqbal^a ; Samina Iqbal^a ; Ajaz Hussain^c ; Rashad Mehmood^d ; Muhammad Tahir Hussain^e ; Muhammad Khalid^f ; Haq Nawaz^f

关键词：Schiff bases ; Synthesis ; Antioxidant activity ; Lipoxygenase inhibition activity ; Antibacterial activity ; Urease activity

刊名：Journal of Saudi Chemical Society

出版年：2016

8.A potent and selective inhibitor targeting human and murine 12/15-LOX

作者：Michelle M. Armstrong^a ; Cody J. Freedman^a ; Joo Eun Jung^b ; Yi Zheng^b ; Chakrapani Kalyanaraman^c ; Matthew P. Jacobson^c ; ^&dagger ; ; Anton Simeonov^d ; David J. Maloney^d ; Klaus van Leyen^b ; Ajit Jadhav^d ; Theodore R. Holman^a ; ^{holman@ucsc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：LOX ; lipoxygenase ; hLOX ; human lipoxygenase ; h15-LOX-2 ; human epithelial 15-lipoxygenase-2 ; h12/15-LOX ; h15-LOX-1 ; human reticulocyte 15-lipoxygenase-1 ; h12-LOX ; human platelet 12-lipoxygenase ; s15-LOX-1 ; soybean 15-lipoxygenase-1 ; h5-LOX ; human leukocyte 5-lipoxygenase ; AA ; arachidonic acid ; LA ; linoleic acid ; 12-HETE ; 12-hydroxy-58 ; 10 ; 14-eicosatetraenoic acid ; 12-HpETE ; 12-hydroperoxyeicosatetraenoic acid ; 15-HpETE ; 15-hydroperoxyeicosatetraenoic acid ; 13-HpODE ; 13-(S)-hydroperoxyoctadecadien

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency

作者：Michelle Armstrong^a ; Christopher van Hoorebeke^a ; Thomas Horn^a ; ^&dagger ; ; Joshua Deschamps^a ; J. Cody Freedman^a ; Chakrapani Kalyanaraman^b ; Matthew P. Jacobson^b ; Theodore Holman^a ; ^{holman@ucsc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：LOX ; lipoxygenase ; h15-LOX-1 ; human reticulocyte 15-lipoxygenase-1 ; tPA ; tissue plasminogen activator ; FDA ; Food and Drug Administration ; s15-LOX-1 ; soybean 15-lipoxygenase-1 ; r15-LOX ; rabbit reticulocyte 15-LOX ; AA ; arachidonic acid ; 12-HpETE ; 12-hydroperoxyeicosatetraenoic acid ; LA ; linoleic acid ; 9R-HpODE ; 9-(R)-hydroperoxyoctadecadienoic acid ; 13-HpODE ; 13-(S)-hydroperoxyoctadecadienoic acid ; 15-HpETE ; 15-hydroperoxyeicosatetraenoic acid ; ICP-MS ; inductively coupled plasma mass spectrometer

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.A fast and efficient method for the preparation of the 5-lipoxygenase inhibitor myxochelin A

作者：Sebastian Schieferdecker ; ^{sebastian.schieferdecker@hki-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Markus Nett

关键词：Myxochelin ; Anticancer ; 5-Lipoxygenase

刊名：Tetrahedron Letters

出版年：2016

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