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在“Elsevier电子期刊”中，命中：257条，耗时：0.020025 秒

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1.Engineered Liver Platforms for Different Phases of Drug Development

作者：Brenton R. Ware¹ ; ² ; Salman R. Khetani² ; ^{skhetani@uic.edu}

关键词：liver-on-a-chip ; microfabrication ; micropatterned co-cultures ; drug-induced liver injury ; primary human hepatocytes

刊名：Trends in Biotechnology

出版年：2017

2.Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology

作者：Ingrid T.G.W. Bijsmans^a ; Alexandra Milona^a ; Noortje Ijssennagger^a ; Ellen C.L. Willemsen^a ; Jos&eacute ; M. Ramos Pittol^a ; Johan W. Jonker^b ; Katja Lange^c ; Guido J.E.J. Hooiveld^c ; Saskia W.C. van Mil^a ; ^{S.W.C.vanMil@umcutrecht.nl}

关键词：ChIP ; chromatin immunoprecipitation ; DIC ; differential interference contrast ; DM ; differentiation medium ; DSG ; Di(N-succinimidyl) glutarate ; EM ; expansion medium ; Fxr ; farnesoid x receptor ; IPA ; Ingenuity Pathway Analysis ; Lxr ; Liver x receptor ; NR ; nuclear receptor ; OCA ; obeticholic acid ; Ppar ; Peroxisome proliferator-activated receptor ; RMA ; robust multiarray analysis ; Rosi ; Rosiglitazone

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2017

3.Structure-activity relationship for branched oxyquinoline HIF activators: Effect of modifications to phenylacetamide “tail”

作者：A.A. Poloznikov^a ; ^{andrey.poloznikov@gmail.com} ; A.A. Zakhariants^b ; S.V. Nikulin^a ; ^c ; N.A. Smirnova^a ; D.M. Hushpulian^a ; I.N. Gaisina^d ; A.G. Tonevitsky^b ; V.I. Tishkov^e ; ^f ; ^g ; I.G. Gazaryan^a ; ^f

关键词：7-Substituted 8-hydroxyquinoline ; HIF prolyl hydroxylase ; HIF1 ODD-luc reporter ; Luciferase assay ; Liver-on-a-chip ; Hepatotoxicity

刊名：Biochimie

出版年：2017

4.A Bioprinted Liver-on-a-Chip for Drug Screening Applications

作者：Stephanie Knowlton¹ ; Savas Tasoglu¹ ; ² ; ^{savas@engr.uconn.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：tissue engineering ; bioprinting ; 3D cell cultures ; liver tissue engineering ; organ-on-a-chip ; microfluidics

刊名：Trends in Biotechnology

出版年：2016

5.Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

作者：Noortje Ijssennagger¹ ; Aafke W.F. Janssen² ; Alexandra Milona¹ ; Jos&eacute ; M. Ramos Pittol¹ ; Danielle A.A. Hollman¹ ; Michal Mokry³ ; Bark Betzel⁴ ; Frits J. Berends⁴ ; Ignace M. Janssen⁴ ; Saskia W.C. van Mil¹ ; ^&dagger ; ; ^{S.W.C.vanmil@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author} ; Sander Kersten² ; ^&dagger ;

关键词：FXR ; farnesoid X Receptor ; OCA ; obeticholic acid ; NASH ; non-alcoholic steatohepatitis ; hPCLS ; human precision cut liver slices ; LDL ; low density lipoprotein ; HDL ; high density lipoprotein ; NAFLD ; non-alcoholic fatty liver disease ; DMSO ; dimethyl sulfoxide ; WT ; wild-type ; RMA ; robust multi-array analysis ; IBMT ; Intensity-Based Moderated T-statistic ; bp ; base pair ; TSS ; transcription start site ; IR1 ; inverted NR-hexamer sequence

刊名：Journal of Hepatology

出版年：2016

6.Protective effects of curcumin against liver fibrosis through modulating DNA methylation

作者：Peng WU^a ; ^b ; Rui HUANG^a ; Ya-Li XIONG^a ; Chao WU^c ; ^{dr.wu@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Liver fibrosis ; Curcumin ; DNA methylation ; Therapy

刊名：Chinese Journal of Natural Medicines

出版年：2016

7.Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease

作者：Mengxi Jiang¹ ; Marcus Klein² ; ³ ; Ulrich M. Zanger² ; ³ ; Mohammad K. Mohammad⁴ ; Matthew C. Cave⁴ ; Nilesh W. Gaikwad⁵ ; Natasha J. Dias⁶ ; Kyle W. Selcer⁶ ; Yan Guo¹ ; ⁷ ; Jinhan He⁸ ; Xiuhui Zhang⁹ ; Qiujin Shen¹⁰ ; Wenxin Qin¹⁰ ; Jiang Li¹ ; Song Li¹ ; Wen Xie¹ ; ¹¹ ; ^{wex6@pitt.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ChIP ; chromatin immunoprecipitation ; CRP ; C-reactive protein ; CYP ; cytochrome P450 ; E2 ; estradiol ; E2S ; estradiol sulfate ; EMSA ; electrophoretic mobility shift assay ; ER ; estrogen receptor ; EST ; estrogen sulfotransferase ; FBS ; fetal bovine serum ; HPH ; human primary hepatocytes ; ICI ; ICI 182 ; 780 ; IHC ; immunohistochemistry ; IL-8 ; interleukin-8 ; IKK ; IκB kinase ; LPS ; lipopolysaccharide ; MCP-1 ; monocyte chemotactic protein-1 ; PDTC ; pyrrolidine dithiocarbamate ; PMA ; phorbol 12-myristate 13-acetate ; S

刊名：Journal of Hepatology

出版年：2016

8.AMPK activates LXRα and ABCA1 expression in human macrophages

作者：Marina Kemmerer^a ; Ilka Wittig^b ; Florian Richter^b ; Bernhard Brü ; ne^a ; ¹ ; Dmitry Namgaladze^a ; ¹ ; ^{namgaladze@biochem.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author}

关键词：ABC ; ATP-binding cassette ; ACC ; acetyl-CoA carboxylase ; AMPK ; AMP-activated protein kinase ; ATF1 ; activating transcription factor-1 ; ChIP ; chromatin immunoprecipitation ; CV ; control virus ; ERK ; extracellular-signal regulated kinase ; HDAC ; histone deacetylase ; KD ; knockdown ; LXR ; liver X receptor ; LXRE ; LXR response element ; mTOR ; mechanistic target of rapamycin ; NCOR1 ; nuclear receptor corepressor 1 ; PPAR ; peroxisome proliferator-activated receptor ; PTM ; post-translational modification

刊名：International Journal of Biochemistry and Cell Biology

出版年：2016

9.Microarray analysis of gene expression in olive flounder liver infected with viral haemorrhagic septicaemia virus (VHSV)

作者：Hyun Kook Cho^a ; Julan Kim^a ; Ji Young Moon^a ; Bo-Hye Nam^a ; Young-Ok Kim^a ; Woo-Jin Kim^a ; Jung Youn Park^a ; Cheul Min An^a ; Jaehun Cheong^b ; Hee Jeong Kong^a ; ^{heejkong@korea.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Viral hemorrhagic septicemia virus ; Olive flounder ; Paralichthys olivaceus ; Microarray analysis ; Gene expression ; Immune response ; Cell cycle ; Energy metabolism

刊名：Fish & Shellfish Immunology

出版年：2016

10.Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice

作者：Zhi-Chun Zhang¹ ; Yan Liu¹ ; Liu-Ling Xiao¹ ; Shu-Fen Li¹ ; Jing-Hui Jiang¹ ; Yue Zhao¹ ; Shu-Wen Qian¹ ; Qi-Qun Tang¹ ; ² ; Xi Li¹ ; ^{lixi@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：NAFLD ; non-alcoholic fatty liver disease ; ChIP ; chromatin immunoprecipitation ; HFD ; high-fat diet ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; FFA ; free fatty acid ; FAS ; fatty acid synthase ; SCD1 ; stearoyl coenzyme A desaturase 1 ; SREBP-1C ; sterol regulatory element binding protein 1C ; ACC ; acetyl coenzyme A carboxylase ; PPAR ; peroxisome proliferator-activated receptor ; LXRα ; liver X receptor alpha ; DGAT ; diacylglycerol acyl coenzyme A acyltransferase ; CPT1 ; carnitine palmito

刊名：Journal of Hepatology

出版年：2015

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