搜索页_ Mammalian target of rapamycin complex 1 (mTORC1)

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1.Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

作者：D. Lana^a ; J. Di Russo^b ; T. Mello^c ; G.L. Wenk^d ; M.G. Giovannini^a ; ^{mariagrazia.giovannini@unifi.it}

关键词：ACQ ; acquisition ; ACh ; acetylcholine ; DMSO ; dimethyl sulfoxide ; IA ; inhibitory avoidance ; i.c.v. ; intracerebroventricular ; i.p. ; intraperitoneal ; mTOR ; mammalian Target of Rapamycin ; mAChR ; muscarinic acetylcholine receptors ; mTORC12 ; mammalian Target of Rapamycin Complex 12 ; MEC ; mecamylamine ; nAChR ; nicotinic acetylcholine receptors ; p70S6K ; p70S6Kinase ; P-mTOR ; phospho-mTOR ; P-p70S6K ; phospho-p70S6K ; RAPA ; rapamycin ; SCOP ; scopolamine ; SEM ; standard error of the mean

刊名：Neurobiology of Learning and Memory

出版年：2017

2.The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1

作者：Barbara Kathage^a ; Sebastian Gehlert^b ; Anna Ulbricht^a ; Laura Lü ; decke^a ; Victor E. Tapia^c ; Zacharias Orfanos^a ; Daniela Wenzel^d ; Wilhelm Bloch^b ; Rudolf Volkmer^c ; Bernd K. Fleischmann^d ; Dieter O. Fü ; rst^a ; & Jö ; rg Hö ; hfeld^a ; ^{hoehfeld@uni-bonn.de}

关键词：BAG3 ; BCL2-associated athanogene ; mTOR ; mammalian target of rapamycin ; mTORC1 ; mammalian target of rapamycin complex 1 ; TSC ; tuberous sclerosis ; CASA ; chaperone-assisted selective autophagy ; CMA ; chaperone-mediated autophagy ; RE ; maximal eccentric resistance exercise ; ES ; electrical stimulation ; MBP ; maltose-binding protein ; CBD ; chitin-binding domain

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

出版年：2017

3.The Journey of the Autophagosome through Mammalian Cell Organelles and Membranes

作者：Diana Molino ; Naï ; ma Zemirli ; Patrice Codogno ; Etienne Morel ; ^{etienne.morel@inserm.fr}

关键词：ER ; endoplasmic reticulum ; ATG ; autophagy-related gene ; mTORC1 ; mammalian target of rapamycin complex 1 ; PI3KC3 ; class III PI3 kinase ; PI3P ; phosphatidyl-inositol-3-phosphate ; COPs ; coating proteins ; SNAREs ; small Rab GTPases ; membrane fusion proteins ; MAMs ; mitochondria-associated membranes ; ERGIC ; ER-to-Golgi intermediate compartment ; TGN ; trans-Golgi network ; PM ; plasma membrane ; LAP ; LC3-associated phagocytosis ; TSC ; tuberous sclerosis complex ; ROS ; reactive oxygen species ; ERS ; ER stress ; T

刊名：Journal of Molecular Biology

出版年：2017

4.A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM

作者：Guangru Xu¹ ; Minghui Zhang¹ ; Hongxing Zhu ; Jinhua Xu ; ^{wuwuuwgdg@aliyun.com}

关键词：TCGA ; The Cancer Genome Atlas ; LIMMA ; Linear Models for Microarray data ; DEGs ; differentially expressed genes ; SVM ; support vector machine ; d-CEA ; draining venous blood ; GEO ; Gene Expression Omnibus ; RMA ; Robust Multichip Average ; RFE ; recursive feature elimination ; ROC ; receiver operation characteristic ; 2D ; two-dimensional ; HES5 ; Hairy and enhancer of split 5 ; RHEB ; Ras homolog enriched in brain ; mTORC1 ; mammalian target of rapamycin complex 1 ; SRY ; sex-determining region Y

刊名：Gene

出版年：2017

5.mTOR up-regulation of PFKFB3 is essential for acute myeloid leukemia cell survival

作者：Yonghuai Feng^a ; ^b ; ^c ; ^d ; ¹ ; ^{yhfengpeking@126.com} ; Liusong Wu^e ; ¹

关键词：Acute myeloid leukemia ; mTOR ; PFKFB3

刊名：Biochemical and Biophysical Research Communications

出版年：2017

6.Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats

作者：Wanchun You^a ; ¹ ; Zhong Wang^a ; ¹ ; Haiying Li^a ; Haitao Shen^a ; Xiang Xu^a ; Genlai Jia^b ; ; Gang Chen^a ; ^{sz_neurosurgery@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：mTOR ; mammalian target of rapamycin ; EBI ; early brain injury ; SAH ; subarachnoid hemorrhage ; SD ; Sprague-Dawley ; BBB ; blood-brain barrier ; aSAH ; aneurysmal subarachnoid hemorrhage ; ICP ; increasing intracranial pressure ; CBF ; cerebral blood flow ; PI3K ; phos-phatidylinositol 3-kinase ; mTORC1 ; mTOR complex 1 ; RAPA ; rapamycin ; p70S6K ; p70 ribosomal protein S6 kinases ; 4EBP1 ; 4E binding protein 1 ; TSC ; tuberous sclerosis complex ; PMSF ; phenylmethylsulfonyl fluoride ; PVDF ; polyvinylidene difluoride ; CN

刊名：Journal of the Neurological Sciences

出版年：2016

7.Role of mTOR in glioblastoma

作者：Zekeriya Duzgun ; Zuhal Eroglu ; Cigir Biray Avci

关键词：mTOR ; mammalian target of rapamycin ; mTOR ; mammalian target of rapamycin ; PI3K ; phosphoinositide 3-kinase ; RICTOR ; rapamycin-insensitive companion of mTOR ; RAPTOR ; regulatory-associated protein of mTOR ; mTORC1 ; mammalian target of rapamycin complex 1 ; DEPTOR ; DEP domain-containing mTOR-interacting protein ; FKBP12 ; FK506-binding intracellular protein ; TSC1 ; Tuberous sclerosis complex 1 ; TSC2 ; tuberous sclerosis complex 2 ; Akt ; Protein kinase B ; PDK1 ; Pyruvate dehydrogenase lipoamide kinase isozym

刊名：Gene

出版年：2016

8.Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

作者：Sergio Portal-Nú ; ñ ; ez^a ; Pedro Esbrit^a ; Marí ; a José ; Alcaraz^b ; Raquel Largo^c ; ^{rlargo@fjd.es" class="auth_mail" title="E-mail the corresponding author} ; ^{rlargocarazo@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ADAMTS ; a disintegrin and metalloproteinase with thrombospondin motifs ; AGEs ; advanced glycation end products ; ATG ; autophagy-related gene ; Col2 ; type II collagen ; DNMT ; DNA methyltransferase ; ERK ; extracellular signal-regulated kinase ; HDAC ; histone deacetylase ; IGF-I ; insulin growth factor I ; iNOS ; inducible NO synthase ; IL ; interleukin ; MAPK ; mitogen-activated kinase ; miRNA ; micro RNA ; MMP ; metalloproteinase ; mTORC1 ; mammalian target of rapamycin complex 1 ; NF-κB ; nuclear factor κ B ; NO ; nitr

刊名：Biochemical Pharmacology

出版年：2016

9.Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells

作者：Sylvia J. Wowro^a ; ¹ ; ^{Sylvia.wowro@charite.de" class="auth_mail" title="E-mail the corresponding author} ; ^{wowro@dhzb.de" class="auth_mail" title="E-mail the corresponding author} ; Katharina R.L. Schmitt^a ; ¹ ; Giang Tong^a ; Felix Berger^a ; ^b ; Stephan Schubert^a

关键词：BL ; Burkitt lymphoma ; BrdU ; bromodeoxyuridine ; CI ; combination index ; CNI ; calcineurin inhibitor ; CsA ; cyclosporin A ; EBV ; Epstein&ndash ; Barr virus ; Eve ; everolimus ; LDH ; lactate dehydrogenase ; mTOR ; mammalian target of rapamycin ; mTORC1 ; mammalian target of rapamycin complex 1 ; mTORi ; MTOR inhibitor ; NHDF ; normal human dermal fibroblast ; NHL ; non-Hodgkin's lymphoma ; PTLD ; post-transplant lymphoproliferative disorder ; SD ; standard deviation ; Tac ; tacrolimus

刊名：International Immunopharmacology

出版年：2016

10.Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis

作者：Gangarao Davuluri¹ ; ^&dagger ; ; Dawid Krokowski² ; ^&dagger ; ; Bo-Jhih Guan² ; Avinash Kumar¹ ; Samjhana Thapaliya¹ ; Dharmvir Singh¹ ; Maria Hatzoglou² ; Srinivasan Dasarathy¹ ; ^{dasaras@ccf.org" class="auth_mail" title="E-mail the corresponding author}

关键词：αKG ; alpha ketoglutarate ; BCAA/LEU ; branched chain amino acids enriched with l-leucine ; CHOP ; C/EBP homology protein ; eIF2α ; eukaryotic initiation factor 2 alpha ; GADD34 ; growth arrest and DNA damage inducible protein 34 ; GCN2 ; general control non-depressible 2 ; KRBB ; krebs ringer bicarbonate buffer ; MEF ; mouse embryonic fibroblasts ; mTORC1 ; mammalian target of rapamycin complex 1 ; PCA ; portacaval anastomosis ; PERK ; PKR like eIF2α kinase ; PKR ; protein kinase RNA regulated ; SLC ; solute linked car

刊名：Journal of Hepatology

出版年：2016

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