作者：Hiroki Suzuki^a ; Kodai Ueno^a ; Takahiro Mizumoto^b ; Yoshiki Seto^a ; Hideyuki Sato^a ; Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp}

关键词：AUC ; area under the curve of blood concentration versus time curve ; BALF ; bronchoalveolar lavage fluid ; BUN ; blood urea nitrogen ; Cmax ; maximum concentration ; CsA ; cyclosporine A ; CsA-RP ; amorphous cyclosporine A-based respirable powder ; FPD ; fine particle dose ; FPF ; fine particle fraction ; HPMC ; hydroxypropyl methylcellulose ; MPO ; myeloperoxidase ; OVA ; ovalbumin ; OVA-RP ; ovalbumin-based respirable powder ; PBS ; phosphate buffer solution ; RP ; respirable powder ; SMSD/CsA-RP ; self-micellizing solid

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Takahiko Saida^a ; ^{saida_takahiko@maia.eonet.ne.jp} ; Jun-ichi Kira^b ; Shuji Kishida^c ; Takashi Yamamura^d ; Yukiko Sudo^e ; Kazutaka Ogiwara^e ; JT Tibung^e ; Nisha Lucas^f ; Meena Subramanyam^f ; On behalf of Natalizumab Trial Principal Investigators

关键词：AE ; adverse event ; ARR ; annualized relapse rate ; AUC ; area under the concentration time curve ; AUC0&ndash ; last ; area under the curve to the last measurable concentration of a dosing interval ; AUC0&ndash ; &infin ; area under the curve to infinity ; AUC0&ndash ; 672 ; area under the curve for dosing interval ; CI ; confidence interval ; CL ; systemic clearance ; Cmax ; maximum concentration ; Ctrough ; trough concentration ; EDSS ; Expanded Disability Status Scale ; ELISA ; enzyme-linked immunosorbent assay ; Gd ; g

刊名：Multiple Sclerosis and Related Disorders

出版年：2017

作者：W. Elger^a ; R. Wyrwa^d ; G. Ahmed^a ; F. Meece^a ; H.B. Nair^a ; B. Santhamma^a ; Z. Killeen^e ; B. Schneider^a ; R. Meister^c ; H. Schubert^b ; K. Nickisch^a ; ^{knickisch@evestra.com} ; ^{klausnickisch@aol.com}

关键词：AUC ; area under the curve ; BW ; body weight ; C0 ; extrapolated concentration time zero (i. v.) ; Cmax ; maximum concentration ; CA-II ; carbonic anhydrase II ; CBG ; cortisol binding globulin ; COC ; combined oral contraceptive ; EDTA ; ethylene diamine tetra acetic acid ; EE ; ethinyl estradiol ; EMATE ; estrone sulfamate ; EP ; estradiol prodrug ; ER ; estrogen receptor ; ERT ; estrogen replacement therapy ; ES ; estradiol sulfamate ; E2 ; estradiol ; FSH ; follicle stimulating hormone ; GH-/IGF1 ; growth hormone / insulin

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

作者：Alison Margolskee^a ; ^{alison.margolskee@manchester.ac.uk} ; Adam S. Darwich^a ; Xavier Pepin^b ; ^c ; Shriram M. Pathak^d ; Michael B. Bolger^e ; Leon Aarons^a ; Amin Rostami-Hodjegan^a ; ^d ; Jonas Angstenberger^f ; Franziska Graf^f ; Loic Laplanche^f ; Thomas Mü ; ller^f ; Sara Carlert^g ; Pankaj Daga^h ; Dó ; nal Murphy^b ; Christer Tannergren^g ; Mohammed Yasin^b ; Susanne Greschat-Schadeⁱ ; Wolfgang Mü ; ckⁱ ; Uwe Muensterⁱ ; Dorina van der Meyⁱ ; Kerstin Julia Frank^j ; Richard Lloyd^k ; Lieve Adriaenssen^l ; Jan Bevernage^l ; Loeckie De Zwart^l ; Dominique Swerts^l ; Christophe Tistaert^l ; An Van Den Bergh^l ; Achiel Van Peer^l ; Stefania Beato^m ; Anh-Thu Nguyen-Trung^m ; Joanne Bennettⁿ ; Mark McAllisterⁿ ; Mei Wongⁿ ; Patricia Zane^o ; Cé ; line Ollier^c ; Pascale Vicat^c ; Markus Kolhmann^p ; Alexander Marker^p ; Priscilla Brun^c ; Florent Mazuir^c ; Sté ; phane Beilles^c ; Marta Venczel^p ; Xavier Boulenc^c ; Petra Loos^p ; Hans Lennernä ; s^q ; Bertil Abrahamsson^g

关键词：API ; active pharmaceutical ingredient ; AUC ; area under the curve ; BCS ; biopharmaceutics classification system ; BP ; blood-to-plasma ratio ; Cmax ; maximum concentration ; CL ; clearance ; Do ; dose number according to BCS ; DDI ; drug-drug interaction ; EFPIA ; European Federation of Pharmaceutical Industries and Associations ; Foral ; absolute oral bioavailability ; Frel ; relative bioavailability ; fup ; fraction unbound in plasma ; IMI ; Innovative Medicines Initiative ; LogP ; logarithm of the octanol/water part

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Ram Sarup Singh^a ; ^{rssingh11@lycos.com} ; Hemant Preet Kaur^a ; Vikas Rana^b ; John F. Kennedy^c

关键词：Aspergillus panamensis ; Cytokines ; Immunomodulatory activity ; Lectin ; Therapeutic potential ; Ulcerative colitis

刊名：International Journal of Biological Macromolecules

出版年：2017

作者：Nanthanit Pholphana^a ; ¹ ; Duangchit Panomvana^b ; ¹ ; Nuchanart Rangkadilok^a ; ^c ; Tawit Suriyo^a ; Porranee Puranajoti^b ; Teerapat Ungtrakul^d ; Wanwisa Pongpun^d ; Saichit Thaeopattha^b ; Phanit Songvut^b ; Jutamaad Satayavivad^a ; ^c ; ^e ; ^{jutamaad@cri.or.th}

关键词：1 ; andrographolide ; 2 ; 14-deoxy-11 ; 12-didehydroandrographolide ; 3 ; neoandrographolide ; 4 ; 14-deoxyandrographolide ; AUC ; area under plasma concentration-time curve ; Cmax ; maximum concentration ; Cl ; clearance ; EDTA ; ethylenediaminetetraacetic acid ; F ; bioavailability ; IS ; internal standard ; Ke ; elimination rate constant ; LLOQ ; lower limit of quantification ; MRT ; mean resident time ; t1/2 ; elimination half-life ; Tmax ; time at the maximum concentration ; Vd ; volume of distribution

刊名：Journal of Ethnopharmacology

出版年：2016

作者：Yuqin Qiu ; Chun Li ; Suohui Zhang ; Guozhong Yang ; Meilin He ; Yunhua Gao ; ^{yhgao@mail.ipc.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Dissolving microneedles ; Artemether ; Poorly water-soluble drugs ; Intradermal delivery

刊名：International Journal of Pharmaceutics

出版年：2016

作者：Edina Pallagi^a ; ^{edinapallagi@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{edina.pallagi@pharm.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Keyhaneh Karimi^b ; Rita Ambrus^b ; Piroska Szabó ; -Ré ; vé ; sz^b ; Ildikó ; Csó ; ka^a

关键词：API ; active pharmaceutical ingredient ; Cmax ; maximum plasma concentration ; CQA ; critical quality attribute ; CPP ; critical process parameter ; EMA ; European Medicines Agency ; FDA ; U.S. Food and Drug Administration ; FPF ; fine particle fraction ; ICH ; International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use ; LEU ; l-leucine ; MA ; β-d-Mannitol ; MX ; low-solubility meloxicam ; MDT ; mean dissolution time ; MMAD ; mass median aerodynamic diameter ; PBS ; phosphate buffe

刊名：International Journal of Pharmaceutics

出版年：2016

作者：Nicolas Darville^a ; ^c ; Marjolein van Heerden^b ; Dirk Marië ; n^b ; Marc De Meulder^b ; Stefaan Rossenu^c ; An Vermeulen^c ; An Vynckier^b ; Sandra De Jonghe^b ; Patrick Sterkens^b ; Pieter Annaert^a ; Guy Van den Mooter^a ; ^{Guy.VandenMooter@pharm.kuleuven.be" class="auth_mail" title="E-mail the corresponding author}

关键词：Intramuscular ; Long-acting ; Paliperidone palmitate ; Clodronate ; Sunitinib ; Flip-flop PK

刊名：Journal of Controlled Release

出版年：2016

作者：John A. Duley^a ; ^{jduley@pharmacy.uq.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Ming Ni^b ; ^{m.ni@uq.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Catherine Shannon^c ; ^{Catherine.Shannon@mater.org.au" class="auth_mail" title="E-mail the corresponding author} ; Ross L. Norris^d ; ¹ ; ^{Ross.Norris@svha.org.au" class="auth_mail" title="E-mail the corresponding author} ; Lesley Sheffield^e ; ^{les.sheffield@genesfx.com" class="auth_mail" title="E-mail the corresponding author} ; Marion Harris^f ; ^{Marion.Harris@southernhealth.org.au" class="auth_mail" title="E-mail the corresponding author} ; Andre B.P. van Kuilenburg^g ; ^{a.b.vankuilenburg@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author} ; Scott Mead^h ; ² ; ^{scott.mead@sesiahs.health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author} ; Andrew Cameronⁱ ; ³ ; ^{andrewcmrn2011@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nuala Helsby^j ; ^{n.helsby@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author} ; Rani George^d ; ^{ranijee21@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bruce G. Charles^b ; ^{b.charles1@uq.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：Thymine ; Dihydrothymine ; Pharmacokinetics ; Fluorouracil toxicity ; Pyrimidine load ; HPLC-MS/MS

刊名：European Journal of Pharmaceutical Sciences

出版年：2016