搜索页_ Metabotropic glutamate receptor subtype 5 (mGlu5)

常用资源

电子图书

期刊论文

学位会议

外文资源

Elsevier电子期刊(195)

在“Elsevier电子期刊”中，命中：195条，耗时：小于0.01 秒

在所有数据库中总计命中：232条

1.Cocaine self-administration, extinction training and drug-induced relapse change metabotropic glutamate mGlu5 receptors expression: Evidence from radioligand binding and immunohistochemistry assays

作者：Lucyna Pomierny-Chamiolo^a ; ^{lpomiern@cm-uj.krakow.pl} ; Joanna Miszkiel^b ; Malgorzata Frankowska^b ; Beata Bystrowska^a ; Malgorzata Filip^b

关键词：Cocaine self-administration ; Extinction training ; Drug-induced relapse ; MGlu5 receptor binding ; MGlu5 receptor immunohistochemistry

刊名：Brain Research

出版年：2017

2.Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences

作者：Daniel Peterlik^a ; Christina Stangl^a ; Amelie Bauer^a ; Anna Bludau^a ; Jana Keller^a ; Dominik Grabski^a ; Tobias Killian^a ; Dominic Schmidt^b ; Franziska Zajicek^a ; Georg Jaeschke^d ; Lothar Lindemann^c ; Stefan O. Reber^e ; Peter J. Flor^a ; ^{peter.flor@ur.de} ; Nicole Uschold-Schmidt^a ; ^{nicole.uschold@ur.de}

关键词：mGlu5 ; Knockout ; CTEP ; Chronic subordinate colony housing ; Chronic psychosocial stress ; Stress-protective phenotype

刊名：Brain, Behavior, and Immunity

出版年：2017

3.N-Alkylpyrido[1‿2‿1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu_1/5 with CNS exposure in rodents

作者：Andrew S. Felts^a ; ^b ; Alice L. Rodriguez^a ; ^b ; Ryan D. Morrison^a ; ^b ; Daryl F. Venable^a ; ^b ; Anna L. Blobaum^a ; ^b ; Frank W. Byers^a ; ^b ; J. Scott Daniels^a ; ^b ; Colleen M. Niswender^a ; ^b ; Carrie K. Jones^a ; ^b ; P. Jeffrey Conn^a ; ^b ; Craig W. Lindsley^a ; ^b ; ^c ; Kyle A. Emmitte^a ; ^b ; ^c ; ^{kyle.emmitte@unthsc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Metabotropic glutamate receptor subtype 1 (mGlu1) ; Metabotropic glutamate receptor subtype 5 (mGlu5) ; Negative allosteric modulator (NAM) ; Central nervous system (CNS) ; G-protein coupled receptor (GPCR)

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Amygdalar activation of group I metabotropic glutamate receptors produces anti- and pro-conflict effects depending upon animal sex in a sexually dimorphic conditioned conflict-based anxiety model

作者：Marí ; a I. De Jesú ; s-Burgos^a ; Stephanie Gonzá ; lez-Garcí ; a^b ; Yanira Cruz-Santa^c ; Nivia L. Pé ; rez-Acevedo^d ; ^{nivia.perez@upr.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Vogel Conflict Test ; Group I metabotropic glutamate receptos ; Estradiol ; Basolateral amygdala ; Sex differences

刊名：Behavioural Brain Research

出版年：2016

5.Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling

作者：Despina E. Ganella^a ; ^b ; ^{despina.ganella@florey.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Pushbalela Thangaraju^b ; Andrew J. Lawrence^a ; ^b ; Jee Hyun Kim^a ; ^b ; ^{drjeehyunkim@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Mglu5 ; Fear ; MTEP ; CDPPB ; Development ; Extinction

刊名：Behavioural Brain Research

出版年：2016

6.Brain α7 nicotinic acetylcholine receptors in MPTP-lesioned monkeys and parkinsonian patients

作者：Marc Morissette^b ; ¹ ; ^{marc.morissette@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author} ; Nicolas Morin^a ; ^b ; ¹ ; ^{nicolas.morin.4@ulaval.ca" class="auth_mail" title="E-mail the corresponding author} ; Laurent Gré ; goire^b ; ^{laurent.gregoire@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author} ; Alex Rajput^c ; ^{ahr128@campus.usask.ca" class="auth_mail" title="E-mail the corresponding author} ; Ali H. Rajput^c ; ^{Ali.Rajput@saskatoonhealthregion.ca" class="auth_mail" title="E-mail the corresponding author} ; Thé ; rè ; se Di Paolo^a ; ^b ; ^{therese.dipaolo@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：AIMs ; abnormal involuntary movements ; BSA ; bovine serum albumin ; DA ; dopamine ; DL ; dorsolateral ; DM ; dorsomedial ; GP ; globus pallidus ; GPe ; external globus pallidus ; GPi ; internal globus pallidus ; Hepes ; 2-[4-(2-hydroxyethyl)-1-piperazinyl] ethanesulfonic acid ; KRH ; Krebs-Ringer Hepes ; L-DOPA ; L-3 ; 4-dihydroxyphenylalanine ; LID ; L-DOPA-induced dyskinesias ; mGlu ; metabotropic glutamate ; MPEP ; 2-methyl-6-(phenylethynyl)pyridine ; MPTP ; 1-methyl-4-phenyl-123 ; 6-tetrahydropyridine ; nACh ; nicotinic ac

刊名：Biochemical Pharmacology

出版年：2016

7.Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration

作者：Bruce G. Jenkins^a ; ¹ ; Aijun Zhu^a ; ¹ ; Pekka Poutiainen^a ; Ji-Kyung Choi^a ; Kun-Eek Kil^a ; Zhaoda Zhang^a ; Darshini Kuruppu^b ; Nurgul Aytan^c ; Alpaslan Dedeoglu^c ; ^d ; Anna-Liisa Brownell^a ; ^{abrownell@partners.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Metabotropic glutamate receptor ; mGlu4 ; mGlu5 ; Parkinson's disease ; Positron emission tomography ; Pharmacological magnetic resonance imaging

刊名：Neuropharmacology

出版年：2016

8.Estrogen receptors modulate striatal metabotropic receptor type 5 in intact and MPTP male mice model of Parkinson’s disease

作者：S. Al-Sweidi^a ; ^b ; M. Morissette^a ; T. Di Paolo^a ; ^b ; ^{therese.dipaolo@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：A ; adenosine ; DA ; dopamine ; CNS ; central nervous system ; CREB ; cAMP response element-binding protein ; DAT ; dopamine transporter ; ERK ; extracellular signal-regulated kinase ; ER ; estrogen receptor ; ERKO ; estrogen receptor knock out ; L-DOPA ; levodopa ; MAPK ; mitogen-activated protein kinase ; mGlu ; metabotropic glutamate ; MPEP ; [2-methyl-6-(phenylethynyl)pyridine ; MPTP ; 1-methyl-4-phenyl-123 ; 6-tetrahydropyridine ; MTEP ; 3-[(2-methyl-1 ; 3-thiazol-4-yl)ethynyl] pyridine ; PD ; Parkinson&rsquo ; s disease

刊名：Journal of Steroid Biochemistry and Molecular Biology

出版年：2016

9.Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu₅ receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia

作者：Susana Conde-Ceide^a ; Jesú ; s Alcá ; zar^a ; Sergio A. Alonso de Diego^a ; Silvia Ló ; pez^a ; Marí ; a Luz Martí ; n-Martí ; n^a ; Carlos M. Martí ; nez-Viturro^a ; Miguel-Angel Pena^a ; Han Min Tong^a ; Hilde Lavreysen^b ; Claire Mackie^c ; Thomas M. Bridges^d ; ^e ; J. Scott Daniels^d ; ^e ; Colleen M. Niswender^d ; ^e ; Carrie K. Jones^d ; ^e ; Gregor J. Macdonald^b ; Thomas Steckler^b ; P. Jeffrey Conn^d ; ^e ; Shaun R. Stauffer^d ; ^e ; Craig W. Lindsley^d ; ^e ; ^{craig.lindsley@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author} ; José ; Manuel Bartolomé ; -Nebreda^a ; ^{jbartolo@its.jnj.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Metabotropic glutamate receptor ; mGlu5 ; N-Methyl-d-aspartate (NMDA) ; Positive allosteric modulator (PAM) ; Schizophrenia

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

作者：John M. Ellard^a ; Andrew Madin^a ; Oliver Philps^a ; Mark Hopkin^a ; Scott Henderson^a ; Louise Birch^a ; Desmond O&rsquo ; Connor^c ; Tohru Arai^d ; Kazuma Takase^e ; Louise Morgan^b ; David Reynolds^b ; Sonia Talma^b ; Eimear Howley^b ; Ben Powney^b ; Andrew H. Payne^a ; Adrian Hall^a ; Jane E. Gartlon^b ; Lee A. Dawson^b ; Luis Castro^a ; Peter J. Atkinson^b ; ^{Peter_Atkinson@eisai.net" class="auth_mail" title="E-mail the corresponding author}

关键词：Metabotropic glutamate receptor 5 (mGlu5) ; Positive allosteric modulator (PAM) ; Cognition ; Tetrahydrobenzotriazole

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

按检索点细分(195)

题名(25)

关键词(28)

文摘(137)

按出版年细分(195)

2027年及以后(4)

2017年(2)

2016年(7)

2015年(2)

2013年(21)

2012年(13)

2011年(11)

2010年(9)

2009年(10)

2008年(16)

2007年(16)

2006年(6)

2005年(16)

2004年(13)

2003年(10)

2002年(13)

2001年(5)

2000年(9)

2000年及以前(12)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700