搜索页_+Monoclonal+antibody+stability

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在“Elsevier电子期刊”中，命中：384条，耗时：0.0549731 秒

在所有数据库中总计命中：645条

1.Diversity selection, screening and quantitative structure-activity relationships of osmolyte-like additive effects on the thermal stability of a monoclonal antibody

作者：Olubukayo-Opeyemi Oyetayo^a ; ^{oyetayophdhbc@gmail.com} ; Oscar Mé ; ndez-Lucio^b ; Andreas Bender^b ; Hans Kiefer^a

关键词：mAb ; Monoclonal antibody ; MOE ; Molecular Operating Environment ; MDS ; Multi-dimensional scaling ; QSAR ; Quantitative structure&ndash ; activity relationship ; DSC ; Differential scanning calorimetry ; DSF ; Differential scanning fluorimetry ; DMSO ; Dimethyl sulfoxide ; NaOH ; Sodium hydroxide ; HCl ; Hydrochloric acid ; LOO-CV ; Leave-one-out cross-validation ; PCA ; Principal components analysis ; PLS ; Partial least squares ; TMAO ; Trimethylamine N-oxide ; Tm ; Melting temperature ; TS potency ; Thermal stabilization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.One-month stability study of a biosimilar of infliximab (Remsima^®) after dilution and storage at 4 °C and 25 °C

作者：V. Vieillard ; ^{victoire.vieillard@aphp.fr} ; A. Astier ; C. Sauzay ; M. Paul

关键词：Monocolonal antibody ; Biosimilar ; Physical stabililty ; Chemical stability ; &ldquo ; In-use&rdquo ; conditions

刊名：Annales Pharmaceutiques Françaises

出版年：2017

3.Prediction of intraocular antibody drug stability using ex-vivo ocular model

作者：Sulabh Patel^a ; ^c ; Jan Olaf Stracke^a ; ^b ; Ulrike Altenburger^a ; Hanns-Christian Mahler^a ; Philipp Metzger^b ; Pankaj Shende^a ; ^c ; Dhananjay Jere^a ; ^{jeredhananjay@gmail.com}

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2017

4.Synergistic Effect of Cavitation and Agitation on Protein Aggregation

作者：Tetsuo Torisu¹ ; ² ; Takahiro Maruno³ ; Yoshinori Hamaji¹ ; Tadayasu Ohkubo² ; ^{ohkubo@phs.osaka-u.ac.jp} ; Susumu Uchiyama³ ; ⁴ ; ^{suchi@bio.eng.osaka-u.ac.jp}

关键词：monoclonal antibody ; stability ; protein aggregation ; microparticles ; biopharmaceutical characterization ; particle size ; adsorption ; desorption

刊名：Journal of Pharmaceutical Sciences

出版年：2017

5.Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity

作者：Natalie Krahn^a ; Maureen Spearman^b ; Markus Meier^a ; July Dorion-Thibaudeau^c ; Matthew McDougall^a ; Trushar R. Patel^d ; Gregory De Crescenzo^c ; Yves Durocher^e ; Jö ; rg Stetefeld^a ; Michael Butler^b ; ^{butler@cc.umanitoba.ca}

关键词：Analytical ultracentrifuge ; CD spectroscopy ; Dynamic light scattering ; Glycosylation inhibitor ; Monoclonal antibody ; N-linked glycosylation ; Surface plasmon resonance

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

6.LC-MS/MS determination of a human mAb drug candidate in rat serum using an isotopically labeled universal mAb internal standard

作者：Wenkui Li ; ^{wenkui.li@novartis.com} ; Hui Lin ; Yunlin Fu ; Jimmy Flarakos

关键词：Stable isotope labeled universal monoclonal antibody (SILuMab) ; LC&ndash ; MS/MS ; Pellet digestion ; Surrogate peptide ; Stable-isotope-labeled peptide IS

刊名：Journal of Chromatography B

出版年：2017

7.Use of quantum dot beads-labeled monoclonal antibody to improve the sensitivity of a quantitative and simultaneous immunochromatographic assay for neuron specific enolase and carcinoembryonic antigen

作者：Kun Xiao^a ; ^{kun_x@foxmail.com} ; Kan Wang^a ; ^b ; ^{wk_xa@163.com} ; Weijian Qin^a ; ^{1602701580@qq.com} ; Yafei Hou^a ; ^{yafeihou@sjtu.edu.cn} ; Wenting Lu^c ; ^{luwenting23@163.com} ; Hao Xu^d ; ^{xudahao75@qq.com} ; Yan Wo^e ; ^{woyansh@163.com} ; Daxiang Cui^a ; ^b ; ^{dxcui@sjtu.edu.cn}

关键词：ICTS ; immunochromatographic test strip ; CEA ; carcinoembryonic antigen ; NSE ; neuron specific enolase ; CA72-4 ; carbohydrate antigen 72-4 ; PSA ; prostate specific antigen ; AFP ; alpha-fetoprotein ; QBs ; quantum dot beads ; QDs ; quantum dots ; SCLC ; small cell lung cancer ; EDC ; 1-ethyl-3-(3- dimethyllaminopropyl)-carbodiimide hydrochloride ; BSA ; bovine serum albumin ; NHS ; N-hydroxy-succinimide ; PBS ; phosphate buffer saline ; PVC ; polyvinyl chloride ; NC ; nitrocellulose ; T1 ; test line 1 ; T2 ; test line 2 ; C

刊名：Talanta

出版年：2017

8.Pre-clinical development of a hydrogen peroxide-inactivated West Nile virus vaccine

作者：Elizabeth A. Poore^a ; ¹ ; Dawn K. Slifka^a ; ¹ ; Hans-Peter Raué ; ^b ; Archana Thomas^b ; Erika Hammarlund^b ; Benjamin K. Quintel^a ; Lindsay L. Torrey^a ; Ariel M. Slifka^a ; Justin M. Richner^d ; Melissa E. Dubois^a ; Lawrence P. Johnson^c ; Michael S. Diamond^d ; ^e ; ^f ; ^g ; Mark K. Slifka^a ; ^b ; Ian J. Amanna^a ; ^{iamanna@najittech.com}

关键词：BDS ; bulk drug substance ; BPL ; β-propiolactone ; cGMP ; current good manufacturing practices ; DENV ; dengue virus ; DP ; drug product ; Env ; envelope protein ; FFA ; focus forming assay ; GLP ; good laboratory practices ; H2O2 ; hydrogen peroxide ; IVRP ; in vitro relative potency ; JEV ; Japanese encephalitis virus ; LOD ; limit of detection ; MAb ; monoclonal antibody ; MCB ; master cell bank ; MOI ; multiplicity of infection ; MVB ; master virus bank ; NT50 ; 50% neutralizing titer ; PFU ; plaque forming unit ; PPV ; porcin

刊名：Vaccine

出版年：2017

9.Development and use of specific ELISA methods for quantifying the biological activity of bevacizumab, cetuximab and trastuzumab in stability studies

作者：Inmaculada Suá ; rez^a ; Antonio Salmeró ; n-Garcí ; a^b ; José ; Cabeza^b ; Luis Fermí ; n Capitá ; n-Vallvey^a ; Natalia Navas^c ; ^{natalia@ugr.es" class="auth_mail" title="E-mail the corresponding author}

关键词：ELISA ; Stability study ; Monoclonal antibody based-medicines ; Bevacizumab ; Cetuximab ; Trastuzumab

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2016

10.Real-time stability of a hepatitis E vaccine (Hecolin®) demonstrated with potency assays and multifaceted physicochemical methods

作者：Xiao Zhang^a ; ^b ; Minxi Wei^d ; Guang Sun^d ; Xin Wang^a ; ^b ; Min Li^a ; ^b ; Zhijie Lin^d ; Zhongyi Li^d ; Yufang Li^a ; ^b ; Mujin Fang^a ; ^b ; Jun Zhang^a ; ^b ; Shaowei Li^a ; ^b ; ^c ; Ningshao Xia^a ; ^b ; ^c ; ^{nsxia@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Qinjian Zhao^a ; ^b ; ^{qinjian_zhao@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Neutralizing epitope ; Hepatitis E virus ; Hepatitis E vaccine ; Monoclonal antibody ; In vivo mouse potency ; In vitro relative potency (IVRP) ; Real-time stability

刊名：Vaccine

出版年：2016

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