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在“Elsevier电子期刊”中，命中：459条，耗时：0.1618904 秒

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1.Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

作者：Ruud A. Woutersen^a ; ^b ; ^{ruud.woutersen@tno.nl} ; ^{ruud.woutersen@iCloud.com} ; Ans E.M.F. Soffers^b ; E. Dinant Kroese^a ; Cyrille A.M. Krul^a ; ^e ; Jan Willem van der Laan^d ; Jan van Benthem^c ; Mirjam Luijten^c

关键词：Rat ; Sub-chronic toxicity ; Carcinogenicity ; Non-genotoxic carcinogens ; Preneoplastic lesions ; Tumours ; Predictivity ; Risk assessment

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

2.Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 2. The biological variability of the murine Local Lymph Node Assay (LLNA) for skin sensitisation

作者：David W. Roberts^a ; ^{D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Anne Marie Api^b ; Aynur O. Aptula^c

关键词：LLNA ; Biological variability ; Non-animal prediction ; QMM

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

3.Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights

作者：Guenter Blaich^a ; ^{guenter.blaich@abbvie.com" class="auth_mail" title="E-mail the corresponding author} ; Andreas Baumann^b ; Sven Kronenberg^c ; Lolke de Haan^d ; Peter Ulrich^e ; Wolfgang F. Richter^c ; Jay Tibbitts^f ; Simon Chivers^g ; Edit Tarcsa^h ; Robert Caldwellⁱ ; Flavio Crameri^c

关键词：Biotherapeutics ; PEGylated biologics ; Gene and cell therapy ; Pharmacokinetics ; Nonclinical safety ; Antibody-drug conjugate ; Immunogenicity ; Cross-reactive species

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

4.Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches

作者：Coralie Dumont ; Joã ; o Barroso ; Izabela Matys ; Andrew Worth ; Silvia Casati ; ^{silvia.casati@ec.europa.eu" class="auth_mail" title="E-mail the corresponding author}

关键词：ACE ; acetone ; AOO ; acetone ; olive oil (4 ; 1 by volume) ; DMF ; dimethylformamide ; EC3 ; effective concentration inducing a stimulation index of 3 ; ETOH/DEP ; Ethanol/diethylphthalate ; EXT ; extreme (ECETOC classification) ; IDR ; Insufficient Dose Response ; MOD ; moderate (ECETOC classification) ; NEG ; negative ; SI ; stimulation index ; TG ; Test Guideline ; TMPTA ; ethyl-2-(hydroxymethyl)-1 ; 3-propanediol triacrylate

刊名：Toxicology in Vitro

出版年：2016

5.6 Effect of placental ischaemia on angiotensin II type 1 receptor autoantibodies (AT1AA) in a non human primate model of experimental preeclampsia: Biomarkers, prediction of preeclampsia

作者：Shikha Aggarwal^a ; Angela Makris^a ; Suzanne Pears^b ; Robert Ogle^c ; John Thompson^d ; Jim Iliopoulos^e ; Annemarie Hennessy^a

刊名：Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

出版年：2016

6.Prediction of bull fertility

作者：Matthew D. Utt ^{mutt@selectsires.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Bovine ; Fertility ; Prediction ; Semen quality ; Spermatozoa

刊名：Animal Reproduction Science

出版年：2016

7.First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B

作者：Antje Blank¹ ; ² ; ^{antje.blank@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Christoph Markert¹ ; Nicolas Hohmann¹ ; Alexandra Carls¹ ; Gerd Mikus¹ ; Thorsten Lehr³ ; Alexander Alexandrov⁴ ; Mathias Haag⁵ ; ⁶ ; ⁷ ; Matthias Schwab⁵ ; ⁶ ; ⁷ ; ⁸ ; Stephan Urban² ; ⁹ ; Walter E. Haefeli¹ ; ²

关键词：NTCP ; sodium taurocholate co-transporting polypeptide ; HBV ; hepatitis B virus ; CHB ; chronic hepatitis B ; HDV ; hepatitis D virus ; DSMB ; data and safety monitoring board ; MABEL ; minimal anticipated biologic effect level ; AE ; adverse event ; ECG ; electrocardiogram ; CTC-AE ; common terminology criteria for adverse events ; LOQ ; limit of quantification ; NCA ; non-compartmental analysis ; NLME ; nonlinear mixed effects ; OFV ; objective function value ; BMI ; body mass index ; VPC ; visual prediction check ; AUC

刊名：Journal of Hepatology

出版年：2016

8.Cross-species prediction of human survival probabilities for accelerated anthrax vaccine absorbed (AVA) regimens and the potential for vaccine and antibiotic dose sparing

作者：G.V. Stark^a ; ^{starkg@battelle.org} ; G.S. Sivko^a ; M. VanRaden^b ; J. Schiffer^c ; K.L. Taylor^b ; J.A. Hewitt^b ; C.P. Quinn^c ; E.O. Nuzum^b

关键词：Anthrax ; Bacillus anthracis ; Correlate of protection ; Bootstrap ; Logistic regression ; Cross-species prediction

刊名：Vaccine

出版年：2016

9.Evaluation of botanical and chemical composition of sheep diet by using faecal near infrared spectroscopy

作者：Nieves Nú ; ñ ; ez-Sá ; nchez ; ^{pa2nusan@uco.es} ; Domingo Carrion ; Francisco Peñ ; a Blanco ; Valeriano Domenech García ; Ana Garzó ; n Sigler ; André ; s Luis Martí ; nez-Marín

关键词：aNDF ; neutral detergent fibre ; CP ; crude protein ; DM ; dry matter ; EE ; ether extract ; MPLS ; modified partial least squares ; MSC ; multiplicative scatter correction ; NFC ; non fibrous carbohydrates ; NIRS ; near infrared reflectance spectroscopy ; r2 ; coefficient of determination of cross validation ; SEC ; standard error of calibration ; SECV ; standard error of cross validation ; SEP ; standard error of prediction ; SNV ; standard normal variate ; T ; outlier samples

刊名：Animal Feed Science and Technology

出版年：2016

10.Chemical and nutritive characteristics of canola meal from Canadian processing facilities

作者：D.I. Adewole^a ; A. Rogiewicz^a ; B. Dyck^b ; B.A. Slominski^a ; ^{bogdan.slominski@umanitoba.ca}

关键词：AA ; amino acids ; CM ; canola meal ; CP ; crude protein ; DM ; dry matter ; NDF ; neutral detergent fiber ; NDICP ; neutral detergent insoluble crude protein ; NSP ; non-starch polysaccharides

刊名：Animal Feed Science and Technology

出版年：2016

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