作者：Rodrigo Cristofoletti¹ ; ² ; Nikunjkumar Patel³ ; Jennifer B. Dressman² ; ^{dressman@em.uni-frankfurt.de}

关键词：dissolution ; physiologically based pharmacokinetic modeling ; bioequivalence ; disease states ; Biopharmaceutics Classification System

刊名：Journal of Pharmaceutical Sciences

出版年：2017

作者：Sundaraj Rajamanikandan^a ; Pappu Srinivasan^b ; ^{sri.bioinformatics@gmail.com}

关键词：Vibrio harveyi ; LuxR ; Molecular docking ; Molecular dynamics simulations ; Binding free energy ; Structure based virtual screening

刊名：Journal of Molecular Structure

出版年：2017

作者：Barry E. Gidal^a ; ^{barry.gidal@wisc.edu} ; Annie M. Clark^b ; ^{annie.Clark@upsher-smith.com} ; Bob Anders^b ; ^{bob.anders@upsher-smith.com} ; Frank Gilliam^c ; ^{f.gilliam@uky.edu}

关键词：Pharmacokinetics ; Dosing ; Epilepsy ; Antiepileptic drug ; Topiramate ; Half-life

刊名：Epilepsy Research

出版年：2017

作者：Daniela Lopes^a ; Sven Jakobtorweihen^b ; ^{jakobtorweihen@tuhh.de} ; Clá ; udia Nunes^a ; Bruno Sarmento^c ; ^d ; Salette Reis^a

关键词：Chol ; cholesterol ; DAPC ; 1 ; 2-diarachidoyl-sn-glycero-3-phosphocholine ; DLPC ; 1 ; 2-dimyristoyl-sn-glycero-3-phosphocholine ; DMPC ; 1 ; 2-dimyristoyl-sn-glycero-3-phosphocholine ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; DPPC ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphocholine ; DPPG ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphoglycerol ; DPPS ; 1 ; 2-dipalmitoyl-sn-glycero-3-phospho-l-serine ; DSC ; differential scanning calorimetry ; DSPC ; 1 ; 2-distearoyl-sn-glycero-3-phosphocholine ; FDA ; Food and Drug Administration

刊名：Progress in Lipid Research

出版年：2017

作者：Sandeep Kumar ; Sandeep Kumar Singh ; ^{dr.sandeep_pharmaceutics@yahoo.com}

关键词：Silk fibroin ; Carvedilol nanoparticles ; LC&ndash ; MS/MS ; Gastroplus&trade ; In silico simulation

刊名：International Journal of Biological Macromolecules

出版年：2017

作者：Alison Margolskee^a ; ^{alison.margolskee@manchester.ac.uk} ; Adam S. Darwich^a ; Xavier Pepin^b ; ^c ; Leon Aarons^a ; Aleksandra Galetin^a ; Amin Rostami-Hodjegan^a ; ^d ; Sara Carlert^e ; Maria Hammarberg^e ; Constanze Hilgendorf^e ; Pernilla Johansson^e ; Eva Karlsson^e ; Dó ; nal Murphy^b ; Christer Tannergren^e ; Helena Thö ; rn^e ; Mohammed Yasin^b ; Florent Mazuir^c ; Olivier Nicolas^c ; Sergej Ramusovic^f ; Christine Xu^g ; Shriram M. Pathak^d ; Timo Korjamo^h ; Johanna Laru^b ; ^h ; Jussi Malkki^h ; Sari Pappinen^h ; Johanna Tuunainen^h ; Jennifer Dressmanⁱ ; Simone Hansmannⁱ ; Edmund Kostewiczⁱ ; Handan He^j ; Tycho Heimbach^j ; Fan Wu^j ; Carolin Hoft^k ; Loic Laplanche^k ; Yan Pang^k ; Michael B. Bolger^l ; Eva Huehn^l ; Viera Lukacova^l ; James M. Mullin^l ; Ke X. Szeto^l ; Chester Costales^m ; Jian Lin^m ; Mark McAllisterⁿ ; Sweta Modi^m ; Charles Rotter^m ; Manthena Varmaⁿ ; Mei Wongⁿ ; Amitava Mitra^o ; Jan Bevernage^p ; Jeike Biewenga^p ; Achiel Van Peer^p

关键词：API ; Active pharmaceutical ingredient ; AUC ; Area under the curve ; BCS ; Biopharmaceutics classification system ; BE ; Bioequivalence ; BP ; Blood-to-plasma ratio ; CL ; Clearance ; CL/F ; Apparent clearance ; Cmax ; Maximum concentration ; Do ; Dose number ; fa ; Fraction absorbed ; FIM ; First in man ; Foral ; Absolute oral bioavailability ; Frel ; Relative bioavailability ; fup ; Fraction unbound in plasma ; IMI ; Innovative Medicines Initiative ; i.v. ; Intravenous ; IR ; Immediate release ; LogP ; Logarithm of the octanol

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Annika Lindqvist^a ; ^{annika.lindqvist@farmbio.uu.se" class="auth_mail" title="E-mail the corresponding author} ; Markus Fridé ; n^a ; ^b ; Margareta Hammarlund-Udenaes^a

关键词：Liposomes ; Nanocarriers ; Brain delivery ; Blood&ndash ; brain barrier ; Release rate ; Modeling and simulation

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

作者：May Almukainzi ; Fakhreddin Jamali ; Ali Aghazadeh-Habashi ; Raimar Lö ; benberg ; ^{raimar.loebenberg@ualberta.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：ACAT ; Advanced Compartmental Absorption and Transit ; BCS ; biopharmaceutical drug classification system ; CAT ; Compartmental Absorption and Transit ; FD ; fast dissolving ; GR ; gastric release ; IR ; immediate release ; IVIVC ; in vivo/in vitro correlations ; MAE ; mean absolute error ; NSAID ; nonsteroidal anti-inflammatory drug ; Obs ; observed ; PSA ; parameter sensitivity analysis ; PK ; pharmacokinetics ; Pre ; predicted ; RR ; regular release ; RMSE ; root mean squared error ; f2 ; similarity factor

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

作者：Rui Chen^a ; Amin Rostami-Hodjegan^b ; ^c ; Haotian Wang^d ; David Berk^b ; Jun Shi^e ; Pei Hu^a ; ^{peihu_pumc@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：CYP2D6 ; Phenotyping method ; Physiologically based pharmacokinetic model ; Virtual population

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

作者：Samridhi Verma ; Sandeep Kumar Singh ; ^{dr.sandeep_pharmaceutics@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：LC&ndash ; MS/MS validation ; Loratadine-SNEDDS ; Pharmacokinetics ; GastroPlus&trade ; simulation ; In vitro&ndash ; in vivo correlation

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016