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1.Design, synthesis and anti-P. falciparum activity of pyrazolopyridine-sulfonamide derivatives

作者：Thais B. Silva^a ; ^b ; Alice M.R. Bernardino^b ; Maria de Lourdes G. Ferreira^a ; Kamilla R. Rogerio^a ; ^c ; ^d ; Leonardo J.M. Carvalho^c ; Nubia Boechat^a ; Luiz C.S. Pinheiro^a ; ^{lpinheiro@far.fiocruz.br" class="auth_mail" title="E-mail the corresponding author}

关键词：Malaria ; Pyrazolopyridine ; Sulfonamide ; Plasmodium falciparum

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

2.Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis

关键词：Pyrazolo[3 ; 4-c]pyridines ; Receptor tyrosine kinase inhibitors ; Angiogenesis ; Vascular endothelial growth factor ; Microarray ; Gene ontology

刊名：European Journal of Medicinal Chemistry

出版年：2016

3.The discovery of new cytotoxic pyrazolopyridine derivatives

作者：Vassiliki Giannouli^a ; Nikolaos Lougiakis^a ; Ioannis K. Kostakis^a ; Nicole Pouli^a ; ; Panagiotis Marakos^a ; Alexios-Leandros Skaltsounis^b ; Sangkil Nam^c ; Richard Jove^d ; David Horne^c ; Roxane Tenta^e ; Harris Pratsinis^f ; Dimitris Kletsas^f

关键词：Pyrazolo[3 ; 4-c]pyridine ; Antiproliferative activity ; Suzuki coupling ; Deazapurines ; Cell-cycle selectivity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists

作者：Daisuke Matsuda^a ; ; Yohei Kobashi^a ; Ayako Mikami^a ; Madoka Kawamura^a ; Fumiyasu Shiozawa^a ; Kenichi Kawabe^a ; Makoto Hamada^a ; Koji Oda^a ; Shinichi Nishimoto^b ; Kayo Kimura^c ; Masako Miyoshi^b ; Noriko Takayama^b ; Hiroyuki Kakinuma^a ; Norikazu Ohtake^a

关键词：Type 2 diabetes mellitus ; GPR119 agonist ; G-protein coupled receptor ; Pyrazolopyridine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Microwave-assisted chemoselective reaction: a divergent synthesis of pyrazolopyridine derivatives with different substituted patterns

作者：Shu-Liang Wang^a ; ; ^b ; Yin-Ping Liu^a ; ; ^b ; Bi-Hui Xu^a ; ; ^b ; Xing-Hang Wang^a ; ; ^b ; Bo Jiang^a ; ; ^b ; ; ^{jiangchem@xznu.edu.cn} ; Shu-Jiang Tu^a ; ; ^b ; ; ^{laotu@xznu.edu.cn} ; ; ^{laotu2001@263.net}

关键词：Three-component reaction ; Macrocyclane-fused pyrazolopyridine ; Microwave heating ; Aminopyrazole

刊名：Tetrahedron

出版年：2011

6.Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities

作者：Mohamed A. El-Borai ; Hala F. Rizk ; Doha M. Beltagy ; Ibrahim Y. El-Deeb

关键词：Enaminones ; Microwave technology ; Antioxidant ; Antitumor ; Antimicrobial activities

刊名：European Journal of Medicinal Chemistry

出版年：2013

7.Pyrazolopyridine inhibitors of B-Raf^V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

作者：Steve Wenglowsky^a ; David Moreno^a ; ^{david.moreno@arraybiopharma.com} ; Joachim Rudolph^b ; Yingqing Ran^b ; Kateri A. Ahrendt^a ; Alisha Arrigo^a ; Ben Colson^a ; Susan L. Gloor^a ; Gregg Hastings^a

关键词：B-RafV600E ; Aqueous solubility ; Single-crystal X-ray ; Crystal packing ; Crystal lattice energy

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

8.The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

作者：Jeffrey A. Pfefferkorn^a ; ^{jeffrey.a.pfefferkorn@pfizer.com} ; Meihua Tu^a ; Kevin J. Filipski^a ; Angel Guzman-Perez^b ; Jianwei Bian^b ; Gary E. Aspnes^b ; Matthew F. Sammons^a ; Wei Song^b ; Jian-Cheng Li^b ; Christopher S. Jones^b ; Leena Patel^b ; Tim Rasmusson^b ; Dongxiang Zeng^b ; Kapil Karki^b ; Michael Hamilton^b ; Richard Hank^b ; Karen Atkinson^b ; John Litchfield^b ; Robert Aiello^b ; Levenia Baker^b ; Nicole Barucci^b ; Patricia Bourassa^b ; Francis Bourbounais^b ; Theresa D’ ; Aquila^b ; David R. Derksen^b ; Margit MacDougall^b ; Alan Robertson^b

关键词：Glucokinase activator ; Type 2 diabetes mellitus

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

9.Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: Aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif

作者：Dai-Shi Su ; John J. Lim ; Elizabeth Tinney ; Thomas J. Tucker ; S ; eep Saggar ; John T. Sisko ; Bang-Lin Wan ; Mary Beth Young ; Kenneth D. Anderson ; Deanne Rudd ; V ; na Munshi ; Carolyn Bahnck ; Peter J. Felock

关键词：Non-nucleoside reverse transcriptase inhibitors (NNRTI) ; Structural– ; activity relationship (SAR) ; Mutant virus ; Aryl substituted pyrazoles ; Surrogate for pyrazolopyridine

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2010

10.Pyrazolopyridine inhibitors of B-Raf^V600E. Part 2: Structure–activity relationships

作者：Steve Wenglowsky^a ; ^{wenglo1056@yahoo.com"" rel=""nofollow} ; Kateri A. Ahrendt^a ; Alex J. Buckmelter^a ; Bainian Feng^b ; Susan L. Gloor^a ; Stefan Gradl^b ; Jonas Grina^a ; Joshua D. Hansen^a ; Ellen R. Laird^a ; Paul Lunghofer^a ; Simon Mathieu^b ; David Moreno^a ; Brad Newhouse^a ; Li Ren^a ; Tyler Risom^a ; Joachim Rudolph^b ; Jeongbeob Seo^a ; Hillary L. Sturgis^a ; Walter C. Voegtli^a ; Zhaoyang Wen^b

关键词：B-Raf^V600E ; Pyrrolopyridine ; Pyrazolopyridine ; Structure– ; activity relationship

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2011

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