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在“Elsevier电子期刊”中，命中：935条，耗时：0.0449763 秒

在所有数据库中总计命中：1,346条

1.Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile

作者：Ahmed H. Abdelazeem^a ; ^b ; ^{ahmed.abdelazeem@pharm.bsu.edu.eg} ; ^{ahmed.pharm@yahoo.com} ; Mohammed T. El-Saadi^a ; Asmaa G. Safi El-Din^a ; Hany A. Omar^c ; ^d ; Samir M. El-Moghazy^e ; ^{samirelmoghazy@gmail.com}

关键词：Selective COX-1 ; Mofezolac ; Diarylthiazole ; Diarylimidazole ; Analgesic ; Anti-inflammatory ; Ulcerogenicity

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.In silico receptor-based drug design of X,Y-benzenesulfonamide derivatives as selective COX-2 inhibitors

作者：David J. Pé ; rez^a ; Orlando Sarabia^a ; Manuel Villanueva-Garcí ; a^b ; Kayim Pineda-Urbina^a ; Á ; ngel Ramos-Organillo^a ; Jorge Gonzalez-Gonzalez^a ; Zeferino Gó ; mez-Sandoval^a ; ^{zgomez@ucol.com} ; Rodrigo Said Razo-Herná ; ndez^a ; ^c ; ^{rrazo@ucol.mx}

关键词：QSAR ; Docking ; Cyclooxygenase ; Benzenesulfonamides ; Drug design ; Artificial neural networks

刊名：Comptes Rendus Chimie

出版年：2017

3.Selective Serotonin Reuptake Inhibitors and Poststroke Epilepsy: A Population-Based Nationwide Study

作者：Chien-Chen Chou ; MD^a ; ^b ; Der-Jen Yen ; MD^a ; ^b ; Yung-Yang Lin ; MD ; PhD^a ; ^c ; ^d ; Yu-Chiao Wang ; MSc^e ; ^g ; Cheng-Li Lin ; MSc^e ; ^g ; Chia-Hung Kao ; MD^f ; ^h ; ⁱ ; ^{d10040@mail.cmuh.org.tw}

关键词：aHR ; adjusted hazard ratio ; DDD ; defined daily dose ; HR ; hazard ratio ; ICD-9-CM ; International Classification of Diseases ; Ninth Revision ; Clinical Modification ; IQR ; interquartile range ; LHID2000 ; Longitudinal Health Insurance Database 2000 ; NHI ; National Health Insurance ; NHIRD ; National Health Insurance Research Database ; PY ; person-year ; SSRI ; selective serotonin reuptake inhibitor

刊名：Mayo Clinic Proceedings

出版年：2017

4.Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase

作者：Idris Raji^a ; Fatima Yadudu^a ; Emily Janeira^e ; Shaghayegh Fathi^a ; Lindsey Szymczak^c ; James Richard Kornacki^c ; Kensei Komatsu^d ; Jian-Dong Li^d ; Milan Mrksich^c ; Adegboyega K. Oyelere^a ; ^b ; ^{aoyelere@gatech.edu}

关键词：HDAC ; histone deacetylase ; HDACi ; histone deacetylase inhibitors ; COX ; cyclooxygenases ; NSAIDs ; non-steroidal anti-inflammatory drugs ; AR ; androgen receptor ; ZBG ; zinc binding group ; PGE2 ; prostaglandin E2

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.Mitochondrial toxicity of selective COX-2 inhibitors via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria

作者：Muzeeb Syed^a ; ^{muzeeb.syed@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Christian Skonberg^b ; Steen Honoré ; Hansen^a

关键词：Drug induced liver injury ; Selective COX-2 inhibitors ; Rat liver mitochondria ; Oxidative phosphorylation ; ATP ; In vitro metabolism

刊名：Toxicology in Vitro

出版年：2016

6.Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

作者：Angela Di Capua^a ; ¹ ; Claudia Sticozzi^b ; Simone Brogi^a ; Margherita Brindisi^a ; Andrea Cappelli^a ; Lidia Sautebin^c ; Antonietta Rossi^c ; Simona Pace^c ; Carla Ghelardini^d ; Lorenzo Di Cesare Mannelli^d ; Giuseppe Valacchi^b ; ^e ; Gianluca Giorgi^a ; Antonio Giordani^f ; Giovanna Poce^g ; Mariangela Biava^g ; Maurizio Anzini^a ; ^{maurizio.anzini@unisi.it" class="auth_mail" title="E-mail the corresponding author}

关键词：COX-2 inhibitors ; 1 ; 5-diarylpyrrole derivatives ; Anti-inflammatory agents ; Antinociceptive agents ; Antiproliferative activity ; Molecular modelling

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition

作者：Malvina Hoxha^a ; ¹ ; Carola Buccellati^a ; ¹ ; Valé ; rie Capra^c ; Davide Garella^b ; Clara Cena^b ; Barbara Rolando^b ; Roberta Fruttero^b ; Silvia Carnevali^a ; Angelo Sala^a ; G.Enrico Rovati^a ; ^{genrico.rovati@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Massimo Bertinaria^b

关键词：AA ; arachidonic acid ; CV ; cardiovascular ; COX ; cyclooxygenase coxibs ; COX-2 ; selective inhibitors ; DMEM ; Dulbecco&rsquo ; s modified eagle&rsquo ; s medium ; EIA ; enzyme immunoassay ; IP ; inositol phosphate ; HEK293 ; human embryonic kidney 293 ; NSAID ; nonsteroidal anti-inflammatory drug ; PG ; prostaglandin ; TXA2 ; thromboxane A2 ; TP ; thromboxane prostanoid receptor

刊名：Pharmacological Research

出版年：2016

8.Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors

作者：Khaled R.A. Abdellatif^a ; ^{khaled.ahmed@pharm.bsu.edu.eg" class="auth_mail" title="E-mail the corresponding author} ; Eman K.A. Abdelall^a ; Wael A.A. Fadaly^a ; Gehan M. Kamel^b

关键词：Anti-inflammatory ; Pyrazoline ; 1 ; 5-Diarylpyrazole ; Cyclooxygenase-2 inhibitors

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis

作者：Xiao-Yuan Lu^&dagger ; ; Zhong-Chang Wang ; ^&dagger ; ; Shen-Zhen Ren ; Fa-Qian Shen ; Ruo-Jun Man ; Hai-Liang Zhu ; ^{zhuhl@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Coumarin ; Sulfonamides ; COX-2 inhibitor ; Anticancer ; Docking simulation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A₂

作者：Varnavas D. Mouchlis^a ; ^{vmouchlis@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Christophe Morisseau^b ; Bruce D. Hammock^b ; Sheng Li^c ; J. Andrew McCammon^a ; ^{jmccammon@ucsd.edu" class="auth_mail" title="E-mail the corresponding author} ; Edward A. Dennis^a ; ^{edennis@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Phospholipase A2 ; Trifluoromethylketones ; Thioether ; DXMS ; Docking ; MD simulations ; Structure&ndash ; activity relationship

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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