搜索页_+Selective+signalling

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

Wiley电子期刊(28)	SpringerLink电子期刊(380)	NATURE电子期刊(49)
Springer电子图书(1)	ProQuest学位论文(1)	Elsevier电子期刊(917)

在“Elsevier电子期刊”中，命中：917条，耗时：0.0219882 秒

在所有数据库中总计命中：1,376条

1.Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

作者：Alexey Goltsov^a ; ^{a.goltsov@abertay.ac.uk} ; Ghassan Tashkandi^b ; ^{s1163633@exseed.ed.ac.uk} ; Simon P. Langdon^b ; ^{Simon.Langdon@ed.ac.uk} ; David J. Harrison^c ; ^{David.Harrison@st-andrews.ac.uk} ; James L. Bown^a ; ^d ; ^{j.bown@abertay.ac.uk}

关键词：Kinetic modelling ; PI3K ; mTOR1 ; PTEN ; Rapamycin ; BEZ235

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Inter- and intra-cellular mechanism of NF-kB-dependent survival advantage and clonal expansion of radio-resistant cancer cells

作者：Hui Yu^a ; ^b ; Natarajan Aravindan^c ; Ji Xu^d ; Mohan Natarajan^a ; ^{natarajan@uthscsa.edu}

关键词：Radiotherapy ; Feedback signaling ; Breast cancer ; Tumor recurrence ; Non-targeted effect

刊名：Cellular Signalling

出版年：2017

3.Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding

作者：Meagan L. Auger ; Stan B. Floresco ; ^{floresco@psych.ubc.ca}

关键词：Gamma-aminobutyric acid ; NMDA receptor ; Prefrontal cortex ; Working memory ; GluN2B ; Schizophrenia

刊名：Neuropharmacology

出版年：2017

4.Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

作者：Xia Li¹ ; Xing-Xing Fan¹ ; Ze-Bo Jiang ; Wings TY Loo ; Xiao-Jun Yao ; Elaine Lai-Han Leung ; ^{lhleung@must.edu.mo} ; Louis WC Chow ; ^{wcchow@must.edu.mo} ; Liang Liu ; ^{lliu@must.edu.mo}

关键词：NSCLC ; non-small cell lung cancer cell ; ROS ; reactive oxygen species ; EGFR ; epidermal growth factor receptor ; T790M ; a substitution mutation of threonine with methionine at position 790 of EGFR ; TrxR ; thioredoxin reductases ; MTT ; 3-(4 ; 5-dimetrylthiazol)-2 ; 5-diphenyltetrazolium bromide ; DCFDA ; dichlorofluorescein diacetate ; PBS ; phosphate-buffered saline ; RIPA ; radioimmunoprecipitation assay ; PARP ; poly (ADP-ribosyl) polymerase ; NAC ; N-acetyl-l-cysteine ; MG132 ; proteasomal degradation pathway inh

刊名：Pharmacological Research

出版年：2017

5.Modulation of TRPV4 by diverse mechanisms

作者：W.G. Darby^a ; M.S. Grace^a ; ^b ; S. Baratchi^a ; P. McIntyre^a ; ^{peter.mcintyre@rmit.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：Cell signalling ; Ion channel ; Post-translational modification ; Receptor signalling ; TRPV4 ; Transient receptor potential ; Osmosensation ; Mechanosensation

刊名：International Journal of Biochemistry and Cell Biology

出版年：2016

6.Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes

作者：Xiaofeng Ma^a ; Hodney Lubin^a ; Enikő Ioja^b ; Orsolya Ké ; kesi^b ; Á ; gnes Simon^b ; Á ; gota Apá ; ti^c ; Tamá ; s I. Orbá ; n^d ; Lá ; szló ; Hé ; ja^b ; Julianna Kardos^b ; ^{kardos.julianna@ttk.mta.hu" class="auth_mail" title="E-mail the corresponding author} ; Istvá ; n E. Markó ; ^a ; ^{istvan.marko@uclouvain.be" class="auth_mail" title="E-mail the corresponding author}

关键词：Azaspiro[4.5]decane scaffold ; γ-Aminobutyric acid (GABA) ; GABA transporter subtype GAT2 (slc6a13) ; ω-Amino acid selectivity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

作者：Susan Pyne^a ; ^{susan.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; David R. Adams^b ; ^{d.r.adams@hw.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Nigel J. Pyne^a ; ^{n.j.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Sphingosine 1-phosphate ; Sphingosine kinase ; S1P receptors ; Intracellular signalling ; Sphingosine kinase inhibitors

刊名：Progress in Lipid Research

出版年：2016

8.In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition

作者：Malvina Hoxha^a ; ¹ ; Carola Buccellati^a ; ¹ ; Valé ; rie Capra^c ; Davide Garella^b ; Clara Cena^b ; Barbara Rolando^b ; Roberta Fruttero^b ; Silvia Carnevali^a ; Angelo Sala^a ; G.Enrico Rovati^a ; ^{genrico.rovati@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Massimo Bertinaria^b

关键词：AA ; arachidonic acid ; CV ; cardiovascular ; COX ; cyclooxygenase coxibs ; COX-2 ; selective inhibitors ; DMEM ; Dulbecco&rsquo ; s modified eagle&rsquo ; s medium ; EIA ; enzyme immunoassay ; IP ; inositol phosphate ; HEK293 ; human embryonic kidney 293 ; NSAID ; nonsteroidal anti-inflammatory drug ; PG ; prostaglandin ; TXA2 ; thromboxane A2 ; TP ; thromboxane prostanoid receptor

刊名：Pharmacological Research

出版年：2016

9.Oestrogen reporter transgenic medaka for non-invasive evaluation of aromatase activity

作者：Petra Spirhanzlova^a ; ^c ; Mathilde Leleu^a ; Anthony Sé ; billot^a ; Gregory F. Lemkine^a ; ^{lemkine@watchfrog.fr" class="auth_mail" title="E-mail the corresponding author} ; Taisen Iguchi^b ; Barbara A. Demeneix^c ; Andrew J. Tindall^a

关键词：Tam ; Tamoxifen ; Fad ; Fadrozole ; Dex ; Dexamethasone ; T3 ; 3 ; 3&prime ; 5&prime ; -triiodo-l-thyronine ; EE2 ; 17α-ethinyl oestradiol ; E2 ; 17β-oestradiol ; EC50 ; Effective concentration 50 (half maximal effective concentration) ; T ; Testosterone ; SEM ; Standard error of the mean ; EDCs ; Endocrine disrupting chemicals ; ChgH ; Choriogenin H ; GFP ; Green fluorescent protein ; DMSO ; Dimethyl sulfoxide ; MS222 ; Ethyl 3-aminobenzoate methanesulfonate ; dph ; Day post hatch ; ER ; Oestrogen receptor ; SERM ; Selective oestro

刊名：Comparative Biochemistry and Physiology, Part C

出版年：2016

10.Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

作者：Amit Nathubhai^a ; ^{a.nathubhai@bath.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Teemu Haikarainen^b ; Penelope C. Hayward^c ; Silvia Muñ ; oz-Descalzo^d ; Andrew S. Thompson^a ; Matthew D. Lloyd^a ; Lari Lehtiö ; ^b ; Michael D. Threadgill^a

关键词：Tankyrase ; PARP ; 2-Arylquinazolin-4-one ; Wnt ; Hydrophobic cavity

刊名：European Journal of Medicinal Chemistry

出版年：2016

按检索点细分(917)

题名(19)

关键词(2)

文摘(653)

按出版年细分(917)

2027年及以后(26)

2017年(4)

2016年(25)

2015年(10)

2014年(1)

2013年(52)

2012年(53)

2011年(53)

2010年(51)

2009年(52)

2008年(75)

2007年(66)

2006年(53)

2005年(44)

2004年(47)

2003年(39)

2002年(32)

2001年(28)

2000年(35)

2000年及以前(171)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700