搜索页_+Small-molecular+inhibitors

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

Wiley电子期刊(34)	SpringerLink电子期刊(762)	NATURE电子期刊(16)	ACS电子期刊(303)
Springer电子图书(1)	ProQuest学位论文(3)	Elsevier电子期刊(1468)

在“Elsevier电子期刊”中，命中：1,468条，耗时：0.1499283 秒

在所有数据库中总计命中：2,587条

1.Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

作者：Xia Li¹ ; Xing-Xing Fan¹ ; Ze-Bo Jiang ; Wings TY Loo ; Xiao-Jun Yao ; Elaine Lai-Han Leung ; ^{lhleung@must.edu.mo} ; Louis WC Chow ; ^{wcchow@must.edu.mo} ; Liang Liu ; ^{lliu@must.edu.mo}

关键词：NSCLC ; non-small cell lung cancer cell ; ROS ; reactive oxygen species ; EGFR ; epidermal growth factor receptor ; T790M ; a substitution mutation of threonine with methionine at position 790 of EGFR ; TrxR ; thioredoxin reductases ; MTT ; 3-(4 ; 5-dimetrylthiazol)-2 ; 5-diphenyltetrazolium bromide ; DCFDA ; dichlorofluorescein diacetate ; PBS ; phosphate-buffered saline ; RIPA ; radioimmunoprecipitation assay ; PARP ; poly (ADP-ribosyl) polymerase ; NAC ; N-acetyl-l-cysteine ; MG132 ; proteasomal degradation pathway inh

刊名：Pharmacological Research

出版年：2017

2.The expression and function of hsp30-like small heat shock protein genes in amphibians, birds, fish, and reptiles

作者：John J. Heikkila ^{heikkila@uwaterloo.ca}

关键词：Xenopus ; Amphibian ; Frog ; Molecular chaperone ; Protein aggregation ; Aggresomes ; Proteasomal inhibition ; Metals ; Phylogeny ; Proteotoxic stress

刊名：Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

出版年：2017

3.Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays

作者：Zhiyuan Shao^a ; ^f ; Pan Xu^b ; ^f ; Wen Xu^c ; ^f ; Linjuan Li^b ; ^d ; Shien Liu^b ; Rukang Zhang^b ; ^d ; Yu-Chih Liu^e ; Chenhua Zhang^e ; Shijie Chen^b ; ^{shijiechen@simm.ac.cn} ; Cheng Luo^b ; ^{cluo@simm.ac.cn}

关键词：Epigenetics ; DNMT3A inhibitors ; Virtual screening ; Molecular docking

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma

作者：Francesca Musumeci^a ; ¹ ; Anna Lucia Fallacara^b ; ¹ ; Chiara Brullo^a ; Giancarlo Grossi^a ; Lorenzo Botta^c ; Pierpaolo Calandro^b ; Mario Chiariello^d ; Miroslava Kissova^e ; Emmanuele Crespan^e ; Giovanni Maga^e ; Silvia Schenone^a ; ^{schensil@unige.it}

关键词：Pyrrolo-pyrimidines ; Src ; Glioblastoma ; Kinase inhibitors ; Small molecules

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Continuing EGFR inhibition beyond progression in advanced non-small cell lung cancer

作者：Timothy A. Yap^a ; ^b ; Aislinn Macklin-Doherty^a ; Sanjay Popat^a ; ^c ; ^{sanjay.popat@rmh.nhs.uk}

关键词：EGFR mutant NSCLC ; Treatment beyond progression

刊名：European Journal of Cancer

出版年：2017

6.Delineating residues for haemolytic activities of snake venom cardiotoxin 1 from Naja naja as probed by molecular dynamics simulations and in vitro validations

作者：Biswajit Gorai ; Thirunavukkarasu Sivaraman ; ^{sivaram@scbt.sastra.edu}

关键词：Heterogeneous bilayer ; Inhibitors ; Molecular dynamics ; RBC lysis ; Snake venom

刊名：International Journal of Biological Macromolecules

出版年：2017

7.Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs

作者：Yohei Yamauchi ; Yuki Miura ; Yasunori Kanaho ; ^{ykanaho@md.tsukuba.ac.jp}

关键词：Arf6 ; GEF ; GAP ; Invasion ; Metastasis ; Tumor angiogenesis ; Tumor growth ; Anti-cancer drugs

刊名：Advances in Biological Regulation

出版年：2017

8.Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer

作者：Shabir Ahmad Ganai ^{Shabir.muntazir82@gmail.com}

关键词：Apigenin ; HATs ; HDACs ; HDACi ; Prostate cancer ; Flavonoid

刊名：Biomedicine & Pharmacotherapy

出版年：2017

9.Systematic Identification of Oncogenic EGFR Interaction Partners

作者：Julia Petschnigg¹ ; Max Kotlyar² ; Louise Blair¹ ; Igor Jurisica² ; ³ ; ⁴ ; ⁵ ; Igor Stagljar⁶ ; ⁷ ; ⁸ ; Robin Ketteler¹ ; ^{r.ketteler@ucl.ac.uk}

关键词：EGF ; epidermal growth factor ; EGFR ; epidermal growth factor receptor ; ERK ; extracellular signal-regulated kinase ; GFP ; green fluorescent protein ; Grb2 ; growth factor receptor-bound protein 2 ; SH ; Src homology ; MAPK ; mitogen-activated protein kinase ; TK ; tyrosine kinase ; TKI ; TK inhibitor ; NSCLC ; non-small cell lung cancer ; MaMTH ; mammalian membrane two-hybrid ; TACC ; transforming acidic coiled-coil protein ; GO ; gene ontology ; Cub ; C-terminal half of ubiquitin ; TF ; transcription factor ; Nub ; N-ter

刊名：Journal of Molecular Biology

出版年：2017

10.Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases

作者：Nadia Leban^a ; ¹ ; Elise Kaplan^a ; ² ; Laurent Chaloin^a ; Sylvain Godreuil^b ; Corinne Lionne^a ; ³ ; ^{lionne@cbs.cnrs.fr}

关键词：AME ; aminoglycoside-modifying enzyme ; AAC ; aminoglycoside N-acetyltransferase ; ANT ; aminoglycoside O-nucleotidyltransferase ; APH ; aminoglycoside O-phosphotransferase ; GOLD ; Genetic Optimization for Ligand Docking

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2017

按检索点细分(1468)

题名(28)

关键词(21)

文摘(899)

按出版年细分(1468)

2027年及以后(52)

2017年(12)

2016年(75)

2015年(31)

2013年(109)

2012年(124)

2011年(128)

2010年(97)

2009年(92)

2008年(121)

2007年(94)

2006年(77)

2005年(67)

2004年(56)

2003年(41)

2002年(47)

2001年(39)

2000年(34)

2000年及以前(172)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700