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Elsevier电子期刊(14)

ACS电子期刊(8)

在“Elsevier电子期刊”中，命中：14条，耗时：小于0.01 秒

在所有数据库中总计命中：22条

1.Toxicological evaluation of a novel umami flavour compound: 2-(((3-(2,3-Dimethoxyphenyl)-1H-1,2,4-triazol-5-yl)thio)methyl)pyridine

作者：Donald S. Karanewsky ; Amy J. Arthur ; ^{amy.arthur@senomyx.com} ; Hanghui Liu ; Bert Chi ; Lily Ida ; Stacy Markison¹

关键词：amu ; atomic mass unit ; AUC ; area under the curve ; CL ; plasma clearance ; Cmax ; peak plasma concentration ; CYP ; cytochrome P450 ; FDA ; Food and Drug Administration ; FEMA ; Flavour and Extract Manufacturers Association of the United States ; FL-no ; FLAVIS number ; GLP ; Good Laboratory Practices ; GMP ; Good Manufacturing Practices ; GPCR ; G-protein-coupled receptor ; GRAS ; generally recognized as safe ; HPBL ; human peripheral blood lymphocytes ; LC/MS ; liquid chromatography with mass spectrometry ; MC ; methyl

刊名：Toxicology Reports

出版年：2016

2.Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

作者：Donald S. Karanewsky ; Amy J. Arthur ; ^{amy.arthur@senomyx.com} ; Hanghui Liu ; Bert Chi ; Lily Ida ; Stacy Markison

关键词：AUC ; area under the curve ; CL ; plasma clearance ; Cmax ; peak plasma concentration ; CYP ; cytochrome P450 ; FDA ; Food and Drug Administration ; FEMA ; Flavour and Extract Manufacturers Association of the United States ; GLP ; Good Laboratory Practices ; GMP ; good manufacturing practices ; GPCR ; G protein-coupled receptors ; HPBL ; human peripheral blood lymphocytes ; JECFA ; Joint FAO/WHO Expert Committee on Food Additives ; LC/MS ; liquid chromatography with mass spectrometry ; MC ; methylcellulose ; mnPCE ; micro

刊名：Toxicology Reports

出版年：2016

3.Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor

作者：Chen Chen ; Wanlong Jiang ; Joe A. Tran ; Fabio C. Tucci ; Beth A. Fleck ; Stacy Markison ; Jenny Wen ; Ajay Madan ; Sam R. Hoare ; Alan C. Foster ; Dragan Marinkovic ; Caroline W. Chen ; Melissa Arellano ; John

关键词：Melanocortin-4 receptor ; Agonist ; Antagonist ; Potency ; Stereochemistry ; Pyrrolidine ; Obesity ; Animal model

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2008

4.Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A_2A receptor antagonists

作者：Xiaohu Zhang ; Jaimie K. Rueter ; Yongsheng Chen ; Manisha Moorjani ; Marion C. Lanier ; Emily Lin ; Raymond S. Gross ; John E. Tellew ; John P. Williams ; S ; ra M. Lechner ; Stacy Markison ; Tanya Joswig ; Siobha

关键词：Parkinson’ ; s disease ; A_2A adenosine receptor antagonists

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2008

5.Pharmacological and pharmacokinetic characterization of 2-piperazine-α-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists

作者：Chen Chen ; Fabio C. Tucci ; Wanlong Jiang ; Joe A. Tran ; Beth A. Fleck ; Sam R. Hoare ; Jenny Wen ; Takung Chen ; Michael Johns ; Stacy Markison ; Alan C. Foster ; Dragan Marinkovic ; Caroline W. Chen ; Melissa

关键词：Melanocortin-4 receptor ; Antagonist ; Pharmacokinetics ; Cachexia ; SAR

刊名：Bioorganic and Medicinal Chemistry

出版年：2008

6.Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity

作者：Joe A. Tran ; Fabio C. Tucci ; Wanlong Jiang ; Dragan Marinkovic ; Caroline W. Chen ; Melissa Arellano ; Stacy Markison ; Beth A. Fleck ; Jenny Wen ; Nicole S. White ; et al.

关键词：Pyrrolidinone ; Synthesis ; Melanocortin-4 receptor ; Antagonist ; Pharmacokinetics ; Cachexia ; Animal model

刊名：Bioorganic and Medicinal Chemistry

出版年：2007

7.Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor

作者：Wanlong Jiang ; Joe A. Tran ; Fabio C. Tucci ; Beth A. Fleck ; Sam R. Hoare ; Stacy Markison ; Jenny Wen ; Caroline W. Chen ; Dragan Marinkovic ; Melissa Arellano ; Alan C. Foster ; Chen Chen

关键词：Synthesis ; Pyrrolidine ; Melanocortin-4 receptor ; Agonist ; Antagonist ; Potency ; Efficacy

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2007

8.Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor

作者：Wanlong Jiang ; Fabio C. Tucci ; Joe A. Tran ; Beth A. Fleck ; Jenny Wen ; Stacy Markison ; Dragan Marinkovic ; Caroline W. Chen ; Melissa Arellano ; Sam R. Hoare ; Michael Johns ; Alan C. Foster ; John Saunders

关键词：Pyrrolidinone ; Melanocortin-4 receptor ; Antagonist ; Cachexia ; CYP3A4 enzyme ; Lipophilicity ; Pharmacokinetics

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2007

9.Targeting melanocortin receptors for the treatment of obesity

作者：Stacy Markison ; Alan C. Foster ; ^{afoster@neurocrine.com}

刊名：Drug Discovery Today: Therapeutic Strategies

出版年：2006

10.A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice

作者：Pontillo ; Joseph ; Tran ; Joseph A. ; Markison ; Stacy ; Joppa ; Margaret ; Fleck ; Beth A. ; Marinkovic ; Dragan ; et. al.

关键词：Melanocortin-4 ; Antagonist ; Piperazinebenzylamine ; Food intake

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2005

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作者(14)

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2016年(2)

2008年(3)

2007年(3)

2006年(1)

2005年(3)

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2000年及以前(1)

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