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在“Elsevier电子期刊”中，命中：212条，耗时：0.1019782 秒

在所有数据库中总计命中：315条

1.Cardiac activation-repolarization patterns and ion channel expression mapping in intact isolated normal human hearts

作者：Tobias Opthof ; PhD^* ; ^&dagger ; ; Carol Ann Remme ; MD ; PhD^* ; Esther Jorge ; DVM ; PhD^&Dagger ; ; Francisco Noriega ; MD^&Dagger ; ; Rob F. Wiegerinck ; PhD^&Dagger ; ; Arlin Tasiam^* ; Leander Beekman^* ; Jesus Alvarez-Garcia ; MD^&Dagger ; ; Cristian Munoz-Guijosa ; MD ; PhD^§ ; ; Ruben Coronel ; MD ; PhD^* ; ^¶ ; ; ^{rubencoronel@gmail.com} ; Juan Cinca ; MD ; PhD^&Dagger ;

关键词：Human heart ; Repolarization pattern ; Activation&ndash ; recovery interval ; Activation pattern ; mRNA expression levels ; Kv7.1 protein ; Cardiac ion channel

刊名：Heart Rhythm

出版年：2017

2.Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

作者：Scott E. Wolkenberg^a ; ^{scott_wolkenberg@merck.com} ; M. Brad Nolt^a ; Mark T. Bilodeau^a ; B. Wesley Trotter^a ; Peter J. Manley^a ; Nathan R. Kett^a ; Kausik K. Nanda^a ; Zhicai Wu^a ; Matthew J. Cato^b ; Stefanie A. Kane^b ; Laszlo Kiss^b ; Robert H. Spencer^b ; Jixin Wang^b ; Joseph J. Lynch^c ; Christopher P. Regan^c ; Gary L. Stump^c ; Bing Li^d ; Rebecca White^d ; Suzie Yeh^d ; Christopher J. Dinsmore^a ; Craig W. Lindsley^a ; George D. Hartman^a

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K⁺ current in human atrial myocytes

作者：Huan Wang^a ; Hong-fei Wang^b ; Chen Wang^a ; Yu-fang Chen^a ; Rong Ma^a ; Ji-zhou Xiang^a ; Xin-ling Du^b ; Qiang Tang^a ; ^{tangqiang_tjmu@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Hesperetin (PubChem CID ; 72281) ; Dimethyl sulfoxide (PubChem CID ; 679) ; BAPTA-AM (PubChem CID ; 2293) ; Flecainide (PubChem CID ; 3356) ; Dapoxetine (PubChem CID ; 71353) ; Maleimide (PubChem CID ; 10935) ; Atropine (PubChem CID ; 174174) ; Cadmium Dichloride (PubChem CID ; 24947) ; Barium Dichloride (PubChem CID ; 25204) ; Ketanserin (PubChem CID ; 3822) ; Nicardipine (PubChem CID ; 4474)

刊名：European Journal of Pharmacology

出版年：2016

4.Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

作者：Yihong Zhang^a ; Charlotte K. Colenso^b ; ¹ ; Aziza El Harchi^a ; Hongwei Cheng^a ; Harry J. Witchel^c ; Chris E. Dempsey^b ; ^{C.Dempsey@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jules C. Hancox^a ; ^{Jules.hancox@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; diLQTS ; drug induced long QT syndrome ; DEA ; desethylamiodarone ; HEK ; human embryonic kidney ; hERG ; human-Ether-à ; -go-go-Related Gene ; IC50 ; half-maximal inhibitory concentration ; IhERG ; ionic current carried by hERG potassium channels ; IKr ; rapid delayed rectifier potassium current ; IKs ; slow delayed rectifier potassium current ; LQTS ; long QT syndrome

刊名：Biochemical Pharmacology

出版年：2016

5.Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

作者：Stefan A. Mann^a ; ^b ; ¹ ; Mohammad Imtiaz^a ; Annika Winbo^c ; ² ; Annika Rydberg^c ; Matthew D. Perry^a ; ^b ; Jean-Philippe Couderc^d ; Bronislava Polonsky^d ; Scott McNitt^d ; Wojciech Zareba^d ; Adam P. Hill^a ; ^b ; ^{a.hill@victorchang.edu.au} ; Jamie I. Vandenberg^a ; ^b ; ^{j.vandenberg@victorchang.edu.au}

关键词：LQTS ; long-QT syndrome ; VM ; ventricular myocyte ; APD ; Action potential duration ; IKr ; rapidly activating delayed rectifier current ; IKs ; slowly activating delayed rectifier current ; INaL ; late (persistent) sodium current ; ICaL ; L-type calcium current ; NCX ; Sodium-calcium exchanger ; NaK ; Sodium-potassium pump

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

6.Proteolytic cleavage in the S1-S2 linker of the Kv1.5 channel does not affect channel function

作者：Andrew Hogan-Cann ; Wentao Li ; Jun Guo ; Tonghua Yang ; Shetuan Zhang ; ^{shetuan.zhang@queensu.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：CHX ; Cycloheximide ; co-IP ; Co-immunoprecipitation ; hERG ; Human ether-a-go-go-related gene ; IKur ; The ultra-rapidly activating delayed rectifier potassium current ; PK ; Proteinase K

刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes

出版年：2016

7.Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

作者：Stefano Morotti^a ; Andrew D. McCulloch^b ; Donald M. Bers^a ; Andrew G. Edwards^c ; ^d ; Eleonora Grandi^a ; ^{ele.grandi@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ACh ; acetylcholine ; AF ; atrial fibrillation ; AP ; action potential ; APD ; action potential duration ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CaMKII ; Ca2 ; +/calmodulin-dependent protein kinase II ; DAD ; delayed afterdepolarization ; EAD ; early afterdepolarization ; Em ; membrane potential ; ICa ; L-type Ca2 ; + current ; INa ; Na+ current ; IKr ; delayed rectifier K+ current ; INCX ; Na+/Ca2 ; + exchanger current ; ISO ; isoproterenol ; NCX ; Na+/Ca2 ; + exchanger ; pAF ; paroxysmal atria

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

8.The positive frequency-dependent electrophysiological effects of the I_Kur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

作者：John Ford ; PhD^* ; James Milnes ; PhD^* ; Said El Haou ; PhD^* ; Erich Wettwer ; PhD^&dagger ; ; Simone Loose ; MD^&dagger ; ; Klaus Matschke ; MD^&Dagger ; ; Benoit Tyl ; MD^§ ; ; Patrick Round ; MBBS^* ; Ursula Ravens ; MD^&dagger ; ; ^{ravens@rcs.urz.tu-dresden.de" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; ANOVA ; analysis of variance ; AP ; action potential ; APA ; action potential amplitude ; APD20 ; APD50 ; APD90 ; action potential duration at 20% ; 50% ; and 90% of repolarization ; cAF ; chronic atrial fibrillation ; DMSO ; dimethyl sulfoxide ; dV/dtmax ; maximum upstroke velocity ; ECG ; electrocardiogram/electrocardiographic ; ERP ; effective refractory period ; HR ; heart rate ; IKur ; ultra-rapidly activating delayed-rectifier potassium current ; pAF ; paroxysmal atrial fibrillation ; PLT20

刊名：Heart Rhythm

出版年：2016

9.Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development

作者：P. Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; C. Regan ; K. Fitzgerald ; P. Gerenser ; J. Travis ; S. Wang ; P. Fanelli ; F. Sannajust

关键词：ANES GP ; anesthetized guinea pig ; AUC ; area under the curve ; CAVB ; complete atrioventricular blockade ; Cmax ; maximal plasmatic concentration ; ECG ; electrocardiogram ; EMw ; electromechanical window ; EMw-10 ; ; &minus ; ; 10% shortening of the EMw ; GP ; guinea pig ; FDA ; Food and Drug Administration ; hERG ; human Ether-a-go-go Related Gene ; HR ; heart rate ; ICH ; International Conference on Harmonization ; IKr ; rapidly-activating delayed rectifier potassium current ; LVP ; left ventricular pressure ; N

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

10.Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

作者：Sandeep Prabhu^a ; ^b ; ^c ; ^d ; Alex J.A. McLellan^a ; ^b ; ^c ; ^d ; Tomos E. Walters^a ; ^c ; ^d ; Meenal Sharma^a ; Alex Voskoboinik^a ; Peter M. Kistler^a ; ^b ; ^d ; ^{peter.kistler@bakeridi.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：3D ; 3 dimensional ; ACE ; angiotensin converting enzyme ; AF ; atrial fibrillation ; APD ; action potential duration ; AV ; atrio-ventricular ; CA ; catheter ablation ; CRP ; C-reactive protein ; CT ; computer tomography ; CV ; cardio-vascular ; ERP ; effective refractory period ; HF ; heart failure ; HTN ; hypertension ; ITO ; transient outward current (potassium) ; IKur ; ultra-rapid delayed rectifier current ; ICaL ; L-type Ca2 ; + current ; IKr ; rapid delayed rectifier current ; IKs ; slow delayed rectifier current ; IK

刊名：Progress in Cardiovascular Diseases

出版年：2015

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