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Elsevier电子期刊(59)

在“Elsevier电子期刊”中，命中：59条，耗时：小于0.01 秒

在所有数据库中总计命中：59条

1.Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

作者：Justine Desroches^a ; ¹ ; Charline Kieffer^a ; ¹ ; Nicolas Primas^a ; Sé ; bastien Hutter^b ; Armand Gellis^a ; Hussein El-Kashef^c ; Pascal Rathelot^a ; Pierre Verhaeghe^d ; ^{pierre.verhaeghe@univ-tlse3.fr} ; Nadine Azas^b ; Patrice Vanelle^a ; ^{patrice.vanelle@univ-amu.fr}

关键词：Quinazoline ; Quinoline ; Quinoxaline ; Thienopyrimidine ; Trichloromethyl goup ; Plasmodium falciparum ; In vitro antiplasmodial activity ; In vitro HepG2 cytotoxicity ; Structure-activity relationships

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

作者：Takaaki Miura^a ; ^{miuratka@chugai-pharm.co.jp} ; Atsushi Matsuo^b ; Terushige Muraoka^b ; Mitsuaki Ide^b ; Kenji Morikami^b ; Takayuki Kamikawa^a ; Masamichi Nishihara^b ; Hirotaka Kashiwagi^b

关键词：TAK1 ; Chemogenomic approach ; Selective Type I inhibitor ; Biophysical screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase

作者：James E. Tarver Jr.^a ; ^{james.tarver2@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Praveen K. Pabba^a ; Joseph Barbosa^a ; Qiang Han^a ; Michael W. Gardyan^a ; Robert Brommage^b ; Andrea Y. Thompson^b ; James M. Schmidt^b ; Alan G.E. Wilson^b ; Wei He^a ; Victoria K. Lombardo^a ; Kenneth G. Carson^a

关键词：Notum Pectinacetylesterase ; Osteoporosis ; Thienopyrimidine ; SAR ; Femur cortical bone thickness

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties

作者：Steffen Bugge^a ; ^{steffen.bugge@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Audun Formo Buene^a ; ^{audun.f.buene@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Nathalie Jurisch-Yaksi^b ; ^{nathalie.jurisch-yaksi@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Ingri Ullestad Moen^a ; ^{ingriumoen@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ellen Martine Skjø ; nsfjell^a ; ^{ellenmsk@stud.ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Eirik Sundby^c ; ^{Eirik.Sundby@hist.no" class="auth_mail" title="E-mail the corresponding author} ; Bå ; rd Helge Hoff^a ; ^{bard.helge.hoff@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author}

关键词：EGFR ; Structure&ndash ; activity relationship (SAR) ; Thieno[2 ; 3-d]pyrimidine ; ADME ; Erlotinib ; Gefitinib ; Zebrafish

刊名：European Journal of Medicinal Chemistry

出版年：2016

5.3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) and molecular docking study of thienopyrimidine and thienopyridine derivatives to explore structural requirements for aurora-B kinase inhibition

作者：Ankit Borisa ; Hardik Bhatt ; ^{hardikbhatt23@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Cancer ; Aurora-B kinase ; CoMFA-RG ; CoMSIA ; Thienopyrimidine and thienopyridine ; Molecular docking

刊名：European Journal of Pharmaceutical Sciences

出版年：2015

6.Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Andrea Brancale^a

关键词：Structure-based virtual screening ; Substituted thieno-pyrimidines ; Anti-HCV activity

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface

作者：Jing Ren^a ; ^c ; ^&dagger ; ; Wei Xu^b ; ^c ; ^&dagger ; ; Le Tang^a ; Minbo Su^b ; Danqi Chen^a ; Yue-Lei Chen^a ; ^c ; Yi Zang^b ; Jia Li^b ; ^c ; Jingkang Shen^a ; ^c ; Yubo Zhou^b ; ^c ; ^{ybzhou@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Bing Xiong^a ; ^c ; ^{bxiong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Menin ; Mixed lineage leukemia ; MLL1 ; SAR ; Inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor

作者：Steffen Bugge^a ; ^{Steffen.Bugge@chem.ntnu.no" class="auth_mail} ; Svein Jacob Kaspersen^a ; ^{Svein.Jacob.Kaspersen@chem.ntnu.no" class="auth_mail} ; Synne Larsen^a ; ^{synnelar@gmail.com" class="auth_mail} ; Unni Nonstad^b ; ^{unni.nonstad@ntnu.no" class="auth_mail} ; Geir Bjø ; rkø ; y^b ; ^c ; ^{geir.bjorkoy@hist.no" class="auth_mail} ; Eirik Sundby^d ; ^{eirik.sundby@hist.no" class="auth_mail} ; Bå ; rd Helge Hoff^a ; ^{bard.helge.hoff@chem.ntnu.no" class="auth_mail} ; ^{bard.hoff@online.no" class="auth_mail}

关键词：Thienopyrimidine ; Benzylamine ; Suzuki-coupling ; EGFR-TK ; SAR ; Erlotinib

刊名：European Journal of Medicinal Chemistry

出版年：21 March, 2014

9.Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents

作者：Ola H. Rizk^a ; Omaima G. Shaaban^a ; ^{omimagaber@yahoo.com} ; Ibrahim M. El-Ashmawy^b

关键词：Synthesis ; Thienopyrimidines ; Fused thienopyrimidines ; Anti-inflammatory activity

刊名：European Journal of Medicinal Chemistry

出版年：2012

10.Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKK尾 inhibitors

作者：Chun-Ho Park^a ; ^c ; ^&dagger ; ; Chulho Lee^b ; ^&dagger ; ; Jee Sun Yang^b ; Bo-Young Joe^c ; Kwangwoo Chun^c ; Hyuntae Kim^b ; ^d ; Hye Yun Kim^e ; Jong Soon Kang^f ; Jangik I. Lee^g ; Myung-Hwa Kim^c ; ^{mhkim@kddf.org" class="auth_mail} ; Gyoonhee Han^b ; ^d ; ^{gyoonhee@yonsei.ac.kr" class="auth_mail}

关键词：CBFPUILCIXXHJL-UHFFFAOYSA-N ; NPRJWSBKNFOZBS-UHFFFAOYSA-N ; APSHXWMOYGDVIH-UHFFFAOYSA-N ; YLCFCJQPTGJQNH-UHFFFAOYSA-N ; HEHKQWYZEKTYQO-UHFFFAOYSA-N ; RCPBANIDLOGVKQ-UHFFFAOYSA-N ; MEAXWIJPDZLBBT-UHFFFAOYSA-N ; MBMGVZBNLWTYTD-UHFFFAOYSA-N ; YEXUENHISODQDA-UHFFFAOYSA-N ; QMBSFOUMSVMKGZ-UHFFFAOYSA-N ; AKAIYXRMJYKWQG-UHFFFAOYSA-N ; DAVRRNUUATXJRF-UHFFFAOYSA-N ; CVFSPHYQJOJKNY-UHFFFAOYSA-N ; AXNFIUHPOZMGKD-UHFFFAOYSA-N ; RTTXTEHHGFJJDV-UHFFFAOYSA-N ; WMGCVFFJSGOODJ-UHFFFAOYSA-N ; RXWNJQISBNBXFN-UHFFFAOYSA-N ; OZKLIKF

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：15 June 2014

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