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Elsevier电子期刊(32)

在“Elsevier电子期刊”中，命中：32条，耗时：0.0669705 秒

在所有数据库中总计命中：54条

1.Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

作者：Hong-Min Ni ; Mitchell R. McGill ; Xiaojuan Chao ; Kuo Du ; Jessica A. Williams ; Yuchao Xie ; Hartmut Jaeschke ; Wen-Xing Ding ; ^{wxding@kumc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AP ; autophagosome ; APAP ; acetaminophen ; APAP-AD ; acetaminophen protein adducts ; AMAP ; 3&prime ; -hydroxyacetanilide ; ALT ; alanine aminotransferase ; CQ ; chloroquine ; CYP2E1 ; cytochome P450 2E1 ; GSH ; glutathione ; HPLC-ED ; high pressure liquid chomatography with electrochemical detection ; LC3 ; microtubule-associated protein light chain 3 ; Leu ; leupeptin ; Ly ; lysosome ; NAPQI ; N-acetyl-p-benzoquinone imine ; mTOR ; mechanistic target of rapamycin ; NAC ; N-acetylcysteine ; PI ; propidium iodide

刊名：Journal of Hepatology

出版年：2016

2.Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J

作者：Luqi Duan^a ; ^{lduan@kumc.edu} ; John S. Davis^b ; ¹ ; ^{John.Davis@nih.gov} ; Benjamin L. Woolbright^a ; ^{bwoolbright@kmc.edu} ; Kuo Du^a ; ^kdu@kumc.edu ; Mala Cahkraborty^b ; ² ; ^{mala.cahkraborty@nih.gov} ; James Weemhoff^a ; ^{jweemhoff@kumc.edu} ; Hartmut Jaeschke^a ; ^{hjaeschke@kumc.edu} ; Mohammed Bourdi^b ; ³ ; ^{mohammed.bourdi@nih.gov}

关键词：Acetaminophen hepatotoxicity ; C57BL/6 sub-strains ; Mitochondrial dysfunction ; Protein adducts ; DNA fragmentation

刊名：Food and Chemical Toxicology

出版年：2016

3.Soy isoflavones reduce acetaminophen-induced liver injury by inhibiting cytochrome P-450-mediated bioactivation and glutathione depletion and increasing urinary drug excretion in rats

作者：Yun-Ta Liu^a ; Yu-Hua Chen^a ; Naoto Uramaru^b ; Ai-Hsuan Lin^a ; Hui-Ting Yang^a ; Chong-Kuei Lii^a ; ^{cklii@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Hsien-Tsung Yao^a ; ^{htyao@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author}

关键词：Soy isoflavones ; Acetaminophen ; Cytochrome P450 ; Liver ; Rats

刊名：Journal of Functional Foods

出版年：2016

4.Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose

作者：Sudeepa Bhattacharyya^a ; ^b ; ^{SBhattacharyya2@uams.edu} ; Lisa Pence^c ; ^{Lisa.Pence@fda.hhs.gov} ; Ke Yan^d ; ^kyan@mcw.edu ; Pritmohinder Gill^a ; ^{PSGill@uams.edu} ; Chunqiao Luo^a ; ^{CLuo@uams.edu} ; Lynda G. Letzig^a ; ^{LetzigLyndaG@uams.edu} ; Pippa M. Simpson^d ; ^{psimpson@mcw.edu} ; Gregory L. Kearns^a ; ^{KearnsGL@archildrens.org} ; Richard D. Beger^c ; ^{Richard.beger@fda.hhs.gov} ; Laura P. James^a ; ^{JamesLauraP@uams.edu}

关键词：Metabolomics ; Phospholipids ; Acetaminophen ; Hepatotoxicity ; Drug

刊名：Toxicology Reports

出版年：2016

5.Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

作者：Yuchao Xie^a ; Mitchell R. McGill^a ; Kuo Du^a ; Kenneth Dorko^a ; Sean C. Kumer^b ; Timothy M. Schmitt^b ; Wen-Xing Ding^a ; Hartmut Jaeschke^a ; ^{hjaeschke@kumc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ALT ; alanine aminotransferase ; AMAP ; N-acetyl-meta-aminophenol ; APAP ; acetaminophen ; BSO ; buthionine sulfoximine ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; GDH ; glutamate dehydrogenase ; GSH ; glutathione ; GSSG ; glutathione disulfide ; JNK ; c-jun-N-terminal kinase ; LDH ; lactate dehydrogenase ; NAPQI ; N-acetyl-p-benzoquinone imine ; PBS ; phosphate-buffered saline ; PHH ; primary human hepatocytes ; PI ; propidium iodide ; PMH ; primary mouse hepatocytes ; TAMH ; TGF-alpha transgenic mouse hepatocytes

刊名：Toxicology and Applied Pharmacology

出版年：2015

6.Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose-response, mechanisms, and clinical implications

作者：Mitchell R. McGill^a ; Margitta Lebofsky^a ; Hye-Ryun K. Norris^b ; Matthew H. Slawson^b ; Mary Lynn Bajt^a ; Yuchao Xie^a ; C. David Williams^a ; Diana G. Wilkins^b ; Douglas E. Rollins^b ; Hartmut Jaeschke^a ; ^{hjaeschke@kumc.edu}

关键词：Acetaminophen ; Hepatotoxicity ; Protein adducts ; Glutathione ; Cellular adduct release

刊名：Toxicology and Applied Pharmacology

出版年：2013

7.Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

作者：Mitchell R. McGill ; C. David Williams ; Yuchao Xie ; Anup Ramach ; ran ; Hartmut Jaeschke

关键词：Acetaminophen ; Hepatotoxicity ; Protein adducts ; Mitochondria ; Oxidant stress ; c-Jun©\N-terminal kinase

刊名：Toxicology and Applied Pharmacology

出版年：2012

8.Glutathione S-transferase pi trapping method for generation and characterization of drug-protein adducts in human liver microsomes using liquid chromatography-tandem mass spectrometry

作者：Hideo Yukinaga ; ^{yukinaga.hideo.ds@daiichisankyo.co.jp} ; Haruo Iwabuchi ; Osamu Okazaki ; Takashi Izumi

关键词：Reactive metabolite ; Protein adduct ; LC&ndash ; MS ; Covalent binding ; Human liver microsomes

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2012

9.Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

作者：Hartmut Jaeschke ; ^{hjaeschke@kumc.edu} ; C. David Williams ; Mitchell R. McGill ; Yuchao Xie ; Anup Ramachandran¹

关键词：Acetaminophen hepatotoxicity ; Carbon tetrachloride ; Protein adducts ; Oxidant stress ; Lipid peroxidation ; Apoptosis and necrosis

刊名：Food and Chemical Toxicology

出版年：2013

10.Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

作者：L. Switzar^a ; L.M. Kwast^b ; H. Lingeman^a ; M. Giera^c ; ^d ; R.H.H. Pieters^b ; W.M.A. Niessen^a ; ^e ; ^{w.m.a.niessen@vu.nl} ; ^{mail@hyphenms.nl}

关键词：ACN ; acetonitrile ; ADR ; adverse drug reaction ; ALAT ; alanine aminotransferase ; APAP ; acetaminophen ; ASAT ; aspartate aminotransferase ; BSA ; bovine serum albumin ; cys34 ; cysteine on position 34 ; cys579 ; cysteine on position 579 ; DTT ; dithiothreitol ; EIC ; ex

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2013

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