搜索页_ azidothymidine (zidovudine)

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1.Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine

作者：Smita S. Ghare^a ; ^c ; Hridgandh Donde^b ; ^c ; Wei-Yang Chen^b ; ^c ; David F. Barker^a ; ^c ; Leila Gobejishvilli^a ; ^b ; ^c ; Craig J. McClain^a ; ^b ; ^c ; Shirish S. Barve^a ; ^b ; ^c ; Swati Joshi-Barve^a ; ^b ; ^c ; ^{s0josh01@louisville.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AZT ; azidothymidine or Zidovudine ; ACR ; acrolein ; ART ; antiretroviral therapy ; ChIP ; chromatin immunoprecipitation ; FasL ; Fas ligand ; H3K9Ac ; histone 3 lysine 9 acetylation ; H3K4Me3 ; histone 3 lysine 4 trimethylation ; RNA Pol II ; RNA polymerase II ; TF ; transcription factor ; UTR ; translational region ; TSR ; transcription start region

刊名：Toxicology in Vitro

出版年：2016

2.Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy

作者：Ayako Hoshi^a ; Takeshi Sakamoto^a ; ^{sakamoto@josai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Takayama^a ; Meiyan Xuan^a ; Mari Okazaki^a ; Tracy L. Hartman^b ; Robert W. Buckheit Jr.^b ; Christophe Pannecouque^c ; Mark Cushman^d ; ^{cushman@purdue.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ADAM ; alkenyldiarylmethane ; NNRTI ; non-nucleoside reverse transcriptase inhibitor ; RT ; reverse transcriptase ; HIV-1 ; human immunodeficiency virus type 1 ; AIDS ; acquired immune deficiency syndrome ; ART ; antiretroviral therapy ; NRTI ; nucleoside reverse transcriptase inhibitor ; PI ; protease inhibitor ; INI ; integrase inhibitors ; FI ; fusion inhibitor ; CCR5I ; CC chemokine receptor inhibitor ; dNTPs ; deoxynucleoside triphosphate ; AZT ; azidothymidine (zidovudine) ; EDCI ; 1-(3-dimethylaminopropyl)-3-ethylc

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

3.Hyperglycemia exacerbates antiretroviral drug combination induced blood-brain barrier endothelial toxicity

作者：Shikha Prasad¹ ; Ravi K. Sajja¹ ; Mohammad A. Kaisar ; Luca Cucullo ; ^{luca.cucullo@ttuhsc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：BBB ; Diabetes ; HAART ; Mitochondria ; Nrf2 ; Oxidative stress ; Zidovudine

刊名：Neurotoxicology

出版年：2016

4.P-glycoprotein limits the absorption of the anti-HIV drug zidovudine through rat intestinal segments

作者：Mario A. Quevedo ; ^a ; ^{alfredoq@fcq.unc.edu.ar"" rel=""nofollow} ; Leandro E. Nieto^a ; Margarita C. Briñ ; ó ; n^a

关键词：Azidothymidine (AZT) ; Gut sac technique ; Intestinal permeation ; P-glycoprotein (P-gp)

刊名：European Journal of Pharmaceutical Sciences

出版年：2011

5.Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli

作者：Deani L. Cooper^a ; Susan T. Lovett ; ^a ; ^{lovett@brandeis.edu}

关键词：Gap repair ; RecF pathway ; Recombination ; SOS response

刊名：DNA Repair

出版年：2011

6.Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism

作者：David M. Mattson ; Iman M. Ahmad ; Disha Dayal ; Arlene D. Parsons ; Nukhet Aykin-Burns ; Ling Li ; Kevin P. Orcutt ; Douglas R. Spitz ; Kenneth J. Dornfeld ; Andrean L. Simons

关键词：Cisplatin ; Azidothymidine ; Cancer ; Oxidative stress ; Mitochondrial membrane potential ; NAC ; BSO ; Free radicals

刊名：Free Radical Biology and Medicine

出版年：2009

7.Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

作者：Tomas Cihlar ; Adrian S. Ray

关键词：NRTI ; HIV reverse transcriptase ; Nucleoside ; Nucleotide ; NRTI resistance

刊名：Antiviral Research

出版年：2010

8.Azidothymidine promotes free radical generation by activated macrophages and hydrogen peroxide-iron-mediated oxidation in a cell-free system

作者：Komarov ; Andrei M. ; Hall ; Jonathon M. ; Weglicki ; William B.

关键词：AZT ; Azidothymidine ; Zidovudine ; AZT phosphate ; AZT glucuronide ; Free radical ; Oxidative stress ; Chemically deacetylated 2&prime ; 7&prime ; -dichlorodihydrofluorescein ; AZT ; azidothymidine ; 3&prime ; -azido-3&prime ; -deoxythymidine ; AZT-MP ; azidothymidine mono

刊名：Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease

出版年：2004

9.Azaindole-based HIV-1 Integrase Specific Inhibitors Display Potent Anti-Retroviral Activity

作者：Scott Butler ; Michael Plewe ; Atsuo Kuki ; Teddy Johnson ; Qinghai Peng ; Dorothy Delisle ; Joanne Graham ; Hua Wu ; Amy Patick

关键词：Rescheduling ; Logistic system ; Genetic algorithms ; Ant colony optimization ; Optimization

刊名：Antiviral Research

出版年：2008

10.Square wave and elimination voltammetric analysis of azidothymidine in the presence of oligonucleotides and chromosomal DNA

作者：Trnková ; Libu&scarone ; Kizek ; René ; Vacek ; Jan

关键词：Azidothymidine (AZT) ; Square wave voltammetry (SWV) ; Linear sweep voltammetry (LSV) ; Elimination voltammetry with linear scan (EVLS) ; Hanging mercury drop electrode (HMDE) ; Oligonucleotides ; PCR product ; Chromosomal DNA

刊名：Bioelectrochemistry

出版年：2004

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