作者：Tomonori Osajima ; Tyuji Hoshino ; ^{hoshino@chiba-u.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Antigen-antibody complex ; Complementarity determining region ; Binding free energy ; Molecular dynamics simulation ; Energetic contribution ; Amino acid residues

刊名：Computational Biology and Chemistry

出版年：2016

作者：Mary H. Foster^a ; ^b ; ^c ; ^{mary.h.foster@dm.duke.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{mhfoster@duke.edu" class="auth_mail" title="E-mail the corresponding author} ; Elizabeth S. Buckley^a ; ^{elizabeth.buckley@duke.edu" class="auth_mail" title="E-mail the corresponding author} ; Benny J. Chen^a ; ^c ; ^{benny.chen@dm.duke.edu" class="auth_mail" title="E-mail the corresponding author} ; Kwan-Ki Hwang^a ; ^d ; ^{kwan-ki.hwang@dm.duke.edu" class="auth_mail" title="E-mail the corresponding author} ; Amy G. Clark^a ; ^b ; ^{amy.clark@duke.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Ag ; antigen ; bnAb ; broadly neutralizing anti-HIV Ig ; CLL ; chronic lymphocytic leukemia ; EBV ; Epstein Barr virus ; GBM ; glomerular basement membrane ; GN ; glomerulonephritis ; GP ; Goodpasture ; GPS ; GP syndrome ; HC ; heavy chain ; HCDR3 ; heavy chain complementarity determining region3 ; HSC ; hematopoietic stem cells ; IMGT ; ImMunoGeneTics information system ; LC ; light chain ; mAb ; monoclonal antibody ; NC1 ; non-collagenous-1 (domain) ; NSG ; NOD-scid-gamma ; V ; variable

刊名：Molecular Immunology

出版年：2016

作者：Mahmood A. Al Kindi^a ; Alex D. Colella^a ; ^b ; Tim K. Chataway^b ; Michael W. Jackson^a ; Jing J. Wang^a ; ¹ ; ^{jing.wang@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Tom P. Gordon^a ; ¹ ; ^{t.gordon@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：aa ; amino acid ; D ; diversity ; 2-DE ; two-dimensional gel electrophoresis ; H-chain ; heavy chain ; HCDR3 ; heavy chain complementarity determining region 3 ; HPLC ; high-performance liquid chromatography ; Ig ; immunoglobulin ; J ; joining ; L-chain ; light chain ; MRM ; multiple reactions monitoring ; MS ; mass spectrometer ; NGS ; next generation sequencing ; Q-TOF ; quadrupole-time of flight ; SLE ; systemic lupus erythematosus ; SS ; Sjö ; gren's syndrome ; V ; variable

刊名：Autoimmunity Reviews

出版年：2016

作者：Changlong Guo ; MD ; PhD¹ ; ^&lowast ; ; Qidi Wang ; MD ; PhD¹ ; ^&lowast ; ; Xiaofang Cao ; MD¹ ; ^{mybrother1984@163.com" class="auth_mail" title="E-mail the corresponding author} ; Ying Yang ; MD ; PhD¹ ; Xin Liu ; PhD¹ ; ² ; Lisha An ; MD¹ ; Ruikun Cai ; PhD¹ ; Meng Du ; MD¹ ; ³ ; Guangyu Wang ; MD¹ ; Yue Qiu ; MD¹ ; ³ ; Zuoqi Peng ; MD¹ ; Jian Han ; MD ; PhD⁴ ; Shuhua Ni ; PhD⁵ ; Xuerui Tan ; MD ; PhD⁵ ; Li Jin ; MD⁶ ; Song Yu ; MD⁷ ; Huiying Wang ; MD⁸ ; Chunlin Wang ; PhD¹ ; ⁹ ; Xingyu Wang ; MD ; PhD¹ ; ² ; Xu Ma ; MD ; PhD¹ ; ³

关键词：umbilical cord blood ; high-throughput sequencing ; TRB-/IgH-CDR3 repertoires

刊名：The Journal of Pediatrics

出版年：2016

作者：Cajetan Dogo-Isonagie^&dagger ; ; Su-Lin Lee^&dagger ; ; Katheryn Lohith^&dagger ; ; Hongbing Liu ; Sivakoteswara R. Mandadapu ; Sabrina Lusvarghi ; Robert D. O&rsquo ; Connor ; Carole A. Bewley ; ^{caroleb@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：CD4 ; cluster of differentiation 4 ; CCR5 ; C&ndash ; C chemokine receptor type 5 ; CXCR4 ; C&ndash ; X&ndash ; C chemokine receptor type 4 ; CCR5 Nt ; CCR5 N-terminus ; CDR-H3 ; complementarity determining region heavy 3 ; HBF4 ; tetrafluoroboric acid ; DMSO ; dimethylsulfoxide

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

作者：Karl J.M. Hanf ; Joseph W. Arndt ; Ling Ling Chen ; Matthew Jarpe ; P. Ann Boriack-Sjodin ; You Li ; Herman W.T. van Vlijmen ; R. Blake Pepinsky ; Kenneth J. Simon ; Alexey Lugovskoy

关键词：CDR ; complementarity-determining region ; DEE ; dead-end elimination ; EC50 ; half maximal effective concentration ; ELISA ; enzyme-linked immunosorbent assay ; FDPB ; finite-difference Poisson&ndash ; Boltzmann ; FACS ; fluorescence-activated cell sorting ; FW4 ; &ldquo ; framework 4&rdquo ; region (the part of a VH or VL domain after CDR 3) ; GMEC ; global minimum-energy conformation ; huKgermB3 ; human kappa germline B3 ; huHgermIGHV1-f ; human heavy germline IGHV1-f ; muHgermV130 ; murine heavy germline V130 ; muKger

刊名：Methods

出版年：1 January, 2014

作者：William H. Rounds^a ; Edward A. Salinas^b ; Tom B. Wilks II^f ; Mikhail K. Levin^b ; Ann J. Ligocki^a ; Carolina Ionete^d ; Carlos A. Pardo^e ; Steven Vernino^a ; Benjamin M. Greenberg^a ; Douglas W. Bigwood^f ; Eric M. Eastman^f ; Lindsay G. Cowell^b ; Nancy L. Monson^a ; ^c ; ^{nancy.monson@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：RRMS ; relapsing&ndash ; remitting multiple sclerosis ; OND ; other neurological disease ; MS ; multiple sclerosis ; CNS ; central nervous system ; SHM ; somatic hypermutation ; CSF ; cerebrospinal fluid ; VH4 ; variable heavy chain family 4 ; NGS ; next generation sequencing ; HCN ; healthy control naï ; ve ; JH ; joining heavy chain ; MF ; mutation frequency ; RMF ; replacement mutation frequency ; CDR ; complementarity determining region ; AGS ; antibody gene signature ; IQR ; interquartile range ; OCB ; oligoclonal bandin

刊名：Gene

出版年：2015

作者：Laura M. Griffin^a ; James R. Snowden^b ; Alastair D.G. Lawson^a ; Ulrich Wernery^c ; Jorg Kinne^c ; Terry S. Baker^a ; ^{terry.baker@ucb.com" class="auth_mail}

关键词：C1q ; multivalent complex and immunoglobulin binding component of the complement activation cascade ; CDR ; complementarity determining region ; CH1 CH2 & CH3 ; first ; second and third heavy chain constant region domains ; FcRn ; neonatal Fc receptor ; C魏 ; kappa light chain constant region ; C位 ; lambda light chain constant region ; FCS ; fetal calf serum ; HCAbs ; heavy chain antibodies ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; IgG1a IgG1b ; IgG2a ; IgG2c ; IgG3 ; immunoglobulin gamma isotype

刊名：Journal of Immunological Methods

出版年：March, 2014

作者：Bochao Zhang^a ; Wenzhao Meng^b ; Eline T. Luning Prak^b ; Uri Hershberg^a ; ^c ; ^{uri.hershberg@drexel.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：B cells ; Germline anotation ; High throughput sequencing ; Gene identification

刊名：Journal of Immunological Methods

出版年：2015

作者：Haruki Hasegawa ; ^{harukih@amgen.com" class="auth_mail} ; Carla Forte ; Irene Barber ; Shanon Turnbaugh ; Janelle Stoops ; Min Shen ; Ai Ching Lim

关键词：BFA ; Brefeldin A ; CB ; crystalline body ; CDR ; complementarity-determining region ; CH1 ; heavy chain constant domain-1 ; CH2 ; heavy chain constant domain-2 ; CH3 ; heavy chain constant domain-3 ; CL ; light chain constant domain ; CHO ; Chinese hamster ovary ; DIC ; differential interference contrast ; ER ; endoplasmic reticulum ; ERGIC ; ER-Golgi intermediate compartment ; Fab ; antigen binding fragment ; Fc ; crystallizable fragment ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HC ; heavy chain ; HEK ; human emb

刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research

出版年：July 2014