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在“Elsevier电子期刊”中，命中：715条，耗时：0.0229936 秒

在所有数据库中总计命中：1,199条

1.Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors

作者：S.N.C. Sridhar^a ; George Ginson^a ; P.O. Venkataramana Reddy^b ; Mukund P. Tantak^b ; Dalip Kumar^b ; ^{dalipk@pilani.bits-pilani.ac.in} ; Atish T. Paul^a ; ^{atish.paul@pilani.bits-pilani.ac.in} ; ^{paulatish@gmail.com}

关键词：Carbazolyl oxoacetamides ; Inhibition kinetics ; Molecular dynamics ; Orlistat ; Pancreatic lipase

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98 Å resolution

作者：Prashant K. Singh ; Harsh V. Sirohi ; Naseer Iqbal ; Pragya Tiwari ; Punit Kaur ; Sujata Sharma ; Tej P. Singh ; ^{tpsingh.aiims@gmail.com}

关键词：Crystal structure ; Intermediate ; Stability ; Inhibition ; Distal heme side

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2017

3.Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

作者：Isabelle V. Maucher^a ; Michael Rü ; hl^a ; Simon B.M. Kretschmer^a ; Bettina Hofmann^a ; Benjamin Kü ; hn^a ; Jasmin Fettel^a ; Anja Vogel^a ; ^b ; Karsten T. Flü ; gel^a ; Georg Manolikakes^c ; Nadine Hellmuth^a ; Ann-Kathrin Hä ; fner^a ; Vahid Golghalyani^a ; Ann-Katrin Ball^a ; Matthias Piesche^d ; ^g ; Carmela Matrone^d ; Gerd Geisslinger^b ; ^e ; Michael J. Parnham^b ; Michael Karas^a ; Dieter Steinhilber^a ; Jessica Roos^a ; ¹ ; ^{roos@pharmchem.uni-frankfurt.de} ; Thorsten J. Maier^d ; ^f ; ¹ ; ^{maier@biomed.au.dk}

关键词：AA ; arachidonic acid ; methyl-BQ ; 2 ; 5-dimethyl-1 ; 4-benzoquinone ; CDDO ; CDDO-methylester ; methoxy-BQ ; 2 ; 3-dimethoxy-5-methyl-p-benzoquinone ; methoxy-NS ; 3-methoxy-β-nitrostyrene ; DMF ; dimethyl fumarate ; GSH ; glutathione ; OH-BQ ; 2 ; 5-dihydroxy-1 ; 4-benzoquinone ; HPLC ; high-performance liquid chromatography ; H(P)ETE ; hydro (peroxy-) eicosatetraenoic acid ; LT ; leukotrienes ; MS ; mass spectrometry ; NAC ; N-acetylcysteine ; NAPQI ; N-acetyl-p-benzoquinone imine ; NEM ; N-ethylmaleimide ; NFA ; nitro-fatty acid

刊名：Biochemical Pharmacology

出版年：2017

4.Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei

作者：Tanja Schirmeister^a ; ^{schirmei@uni-mainz.de} ; Janina Schmitz^b ; Sascha Jung^a ; Torsten Schmenger^c ; R. Luise Krauth-Siegel^c ; Michael Gü ; tschow^b

关键词：Dipeptide nitrile ; Cysteine protease ; Rhodesain ; Inhibitor ; Trypanosoma

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

5.Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition

作者：Oksana Ryabtsova^a ; Jurgen Joossens^a ; Pieter Van Der Veken^a ; Wim Vanden Berghe^b ; Koen Augustyns^a ; Hans De Winter^a ; ^{hans.dewinter@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author}

关键词：Covalent inhibition ; Glucocorticoid receptor ; Segra ; GSK866 ; Inflammation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides

作者：Arwin J. Brouwer^a ; ^&dagger ; ; Natalia Herrero Á ; lvarez^b ; ^&dagger ; ; Adriano Ciaffoni^a ; Helmus van de Langemheen^b ; Rob M.J. Liskamp^a ; ^b ; ^{r.m.j.liskamp@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; ^{Robert.liskamp@glasgow.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Drug design ; Peptido vinyl sulfonyl fluoride ; Proteasome ; Irreversible inhibition ; Dual warhead

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites

作者：Aneesh Karkhanis^a ; Hui Yuan Lam^a ; Gopalakrishnan Venkatesan^a ; Siew Kwan Koh^b ; Christina Li Lin Chai^a ; Lei Zhou^b ; Yanjun Hong^a ; Pipin Kojodjojo^c ; Eric Chun Yong Chan^a ; ^{phaccye@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author}

关键词：AA ; arachidonic acid ; ACN ; acetonitrile ; AF ; atrial fibrillation ; CYP2D6 ; cytochrome P450 2D6 ; CYP2J2 ; cytochrome P450 2J2 ; CYP3A4 ; cytochrome P450 3A4 ; CYP3A5 ; cytochrome P450 3A5 ; DDI ; drug&ndash ; drug interaction ; EET ; epoxyeicosatrienoic acid ; GSH ; glutathione ; k ; intrinsic elimination rate constant ; Ki ; reversible inhibition constant ; KI ; inactivator concentration at half-maximum inactivation rate constant ; kinact ; maximum inactivation rate constant ; Km ; Michaelis&ndash ; Menten constant ; Kobs

刊名：Biochemical Pharmacology

出版年：2016

8.Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1

作者：Tony Christopeit^a ; Anastasia Albert^b ; Hanna-Kirsti S. Leiros^a ; ^{hanna-kirsti.leiros@uit.no" class="auth_mail" title="E-mail the corresponding author}

关键词：MBL ; metallo-β-lactamase ; SBL ; serine-β-lactamase ; NDM-1 ; New Delhi metallo-β-lactamase ; SPR ; surface plasmon resonance ; MS ; mass spectrometry ; TEV ; tobacco etch virus ; IMAC ; immobilized metal ion affinity chromatography ; IPTG ; isopropyl-β-d-thiogalactopyranoside ; ESI ; electrospray ionization ; LE ; ligand efficiency ; MS/MS ; tandem mass spectrometry

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

作者：Ka C. Lee^a ; Rebecca L. Bramley^a ; Ian G. Cowell^a ; Graham H. Jackson^b ; Caroline A. Austin^a ; ^{caroline.austin@ncl.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：DNA topoisomerase II ; Proteasome ; Mitoxantrone ; Velcade ; MG132

刊名：Biochemical Pharmacology

出版年：2016

10.Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method

作者：Cyril Corbet^a ; ¹ ; Hé ; loï ; se Ragelle^b ; ¹ ; ² ; Vincent Pourcelle^c ; ¹ ; Ké ; vin Vanvarenberg^b ; Jacqueline Marchand-Brynaert^c ; Vé ; ronique Pré ; at^b ; ³ ; Olivier Feron^a ; ³ ; ^{olivier.feron@uclouvain.be" class="auth_mail" title="E-mail the corresponding author}

关键词：SiRNA ; Chitosan ; RGD peptidomimetic ; Tumor metabolism ; Lactate ; Glutamine

刊名：Journal of Controlled Release

出版年：2016

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