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1.Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

作者：Peter Sandner^a ; ^b ; ^{peter.sandner@bayer.com} ; Johannes Peter Stasch^a ; ^c

关键词：Soluble guanylate cyclase ; Cyclic guanosine monophosphate

刊名：Respiratory Medicine

出版年：2017

2.Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice

作者：Kelly Decaluwé ; PhD¹ ; Bart Pauwels ; PhD¹ ; Charlotte Boydens ; MSc¹ ; Robrecht Thoonen ; PhD² ; Emmanuel S. Buys ; PhD³ ; Peter Brouckaert ; PhD⁴ ; ⁵ ; Johan Van de Voorde ; PhD¹ ; ^{johan.vandevoorde@UGent.be}

关键词：Soluble Guanylate Cyclase ; Apo-sGC ; Erectile Dysfunction ; Oxidative Stress ; Soluble Guanylate Cyclase Activators ; Soluble Guanylate Cyclase Stimulators

刊名：The Journal of Sexual Medicine

出版年：2017

3.Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension

作者：Linda Vignozzi^a ; Annamaria Morelli^b ; Ilaria Cellai^a ; Sandra Filippi^c ; Paolo Comeglio^a ; Erica Sarchielli^b ; Elena Maneschi^a ; Gabriella Barbara Vannelli^b ; Luciano Adorini^d ; Mario Maggi^a ; ^e ; ^{mario.maggi@unifi.it}

关键词：ACE2 ; angiotensin-converting enzyme 2 ; Ach ; acetylcholine ; BA ; bile acid ; BMP2 ; bone morphogenetic protein 2 ; BMPR1A ; bone morphogenetic protein receptor 1-a ; BW ; body weight ; CDCA ; chenodeoxycholic acid ; cGMP ; cyclic guanosine monophosphate ; COX2 ; cyclooxygenase-2 ; ECs ; endothelial cells ; ET-1 ; endothelin-1 ; ETA ; endothelin receptor type A ; ETB ; endothelin receptor type B ; FXR ; farnesoid X receptor ; GCSa3 ; guanylate cyclase subunit type 1a3 ; GCSb3 ; guanylate cyclase subunit type 1b3 ; IL-1β ; int

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

4.Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice

作者：Kabita Pradhan^a ; ¹ ; ² ; Akylbek Sydykov^a ; ¹ ; ² ; Xia Tian^a ; ¹ ; Argen Mamazhakypov^a ; ¹ ; Balram Neupane^a ; ¹ ; Himal Luitel^a ; ¹ ; Norbert Weissmann^a ; ¹ ; Werner Seeger^a ; ^b ; ¹ ; Friedrich Grimminger^a ; ¹ ; Axel Kretschmer^c ; ¹ ; Johannes-Peter Stasch^c ; ¹ ; Hossein Ardeschir Ghofrani^a ; ¹ ; Ralph Theo Schermuly^a ; ¹ ; ^{ralph.schermuly@innere.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author}

关键词：PH ; pulmonary hypertension ; LHD ; left heart disease ; CHF ; chronic heart failure ; LV ; left ventricular ; RV ; right ventricular ; NO ; nitric oxide ; sGC ; soluble guanylate cyclase ; PDE ; phosphodiesterase ; cGMP ; cyclic guanosine monophosphate ; TAC ; transverse aortic constriction ; LVEDD ; left ventricular end-diastolic diameter ; LVESD ; left ventricular end-systolic diameter ; PAAT ; pulmonary artery acceleration time ; PAET ; pulmonary artery ejection time ; RVSP ; right ventricular systolic pressure ; TAPSE

刊名：International Journal of Cardiology

出版年：2016

5.Possible involvement of l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant-like effect of Wuling mycelia powder in rat

作者：Yun-fei Tan ; Zheng-luan Liao ; Ya-ju Qiu ; Jun-peng Zhu ; En-yan Yu ; ^{yuenyan@aliyun.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Sildenafil ; 7-Nitroindazole ; Methylene

刊名：Biomedicine & Pharmacotherapy

出版年：2016

6.S-Nitrosothiols—NO donors regulating cardiovascular cell proliferation: Insight into intracellular pathway alterations

作者：Marek Rychter^a ; Caroline Gaucher^b ; Ariane Boudier^b ; Pierre Leroy^b ; Janina Lulek^a ; ^{jlulek@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：EDRF ; endothelium-derived relaxing factor ; sGC ; soluble guanylate cyclase ; cGMP ; cyclic guanosine monophosphate ; RSNO ; S-nitrosothiol ; GSNO ; S-nitrosoglutathione ; PTM ; post-translational modifications ; NOS ; nitric oxide synthase ; GTP ; guanosine triphospate ; cGMP ; cyclic guanosine monophosphate ; VSMC ; vascular smooth muscle cells ; ACh ; acetylcholine ; VEGF ; vascular endothelial growth factor ; BDK ; bradykinin ; eNOS ; endothelial nitric oxide synthase ; PRT ; protein ; Trx ; thioredoxin ; VASP ; vasodilato

刊名：International Journal of Biochemistry and Cell Biology

出版年：2016

7.The molecular mechanism of heme loss from oxidized soluble guanylate cyclase induced by conformational change

作者：Jie Pan^a ; Xiaoxue Zhang^a ; Hong Yuan^a ; Qiming Xu^b ; Huijuan Zhang^a ; Yajun Zhou^a ; Zhong-Xian Huang^a ; Xiangshi Tan^a ; ^b ; ^{xstan@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：sGC ; soluble guanylate cyclase ; NO ; nitric oxide ; FRET ; fluorescence resonance energy transfer ; H-NOX domain ; heme-NO/O2-binding domain ; PAS domain ; Per/Arnt/Sim domain ; CC ; helical domain ; Ns H-NOX ; the H-NOX domain of Nostoc sp ; FlAsH-EDT2 ; fluorescein arsenical helix binder ; GTP ; guanosine 5&prime ; -triphosphate ; cGMP ; 3&prime ; 5&prime ; -cyclic guanosine monophosphate ; DEA/NO ; diethylammonium (Z)-1-(N ; N-diethylamino) diazen-1-ium-1 ; 2-diolate ; EPR ; electron paramagnetic resonance ; ODQ ; 1H-(1

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2016

8.Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity

作者：Arumugam Ramakrishnan ; Natesan Vijayakumar ; ^{nvkbiochem@yahoo.co.in} ; Mani Renuka

关键词：NH4Cl ; ammonium chloride ; i.p ; intraperitonial injection ; b.w. ; body weight ; NO ; nitric oxide ; CPS-1 ; carbamoylphosphate synthetase-1 ; OTC ; ornithine transcarbamoylase ; ASS ; argininosuccinate synthetase ; ASL ; argininosuccinate lyase ; CNS ; central nervous system ; Na+/K+ ATPase ; sodium/potassium ATPase ; NH3 ; ammonia ; GS ; glutamine synthetase ; NOS ; nitric oxide synthase ; NMDA ; N-methyl-d-aspartic acid ; cGMP ; cyclic guanosine monophosphate ; sGC ; soluble guanylate cyclase ; ROS/RNS ; reactive oxygen sp

刊名：Biomedicine & Pharmacotherapy

出版年：2016

9.Utility of different outcome measures for the nitroglycerin model of migraine in mice

关键词：5-HT ; serotonin ; CGRP ; calcitonin gene related peptide ; NTG ; nitroglycerin ; NO ; nitrogen monoxide ; nNOS ; neuronal nitrogen monoxide synthase ; TNC ; trigeminal nucleus caudalis ; TRP ; transient receptor potential ; TRG ; trigeminal ganglion ; PBS ; phosphate-buffered saline ; PBS-T ; Triton-X containing PBS ; DAB ; diaminobenzidine ; sGC ; soluble guanylate cyclase ; cGMP ; cyclic guanosine monophosphate ; i.p. ; intraperitoneal ; i.v. ; intravenous ; s.c. ; subcutaneous

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

10.Innovative trends and perspectives for erectile dysfunction treatment: A systematic review

作者：Ezzat A. Ismail ; Ahmed I. El-Sakka ; ^{aielsakka@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ADSCs ; adipose tissue-derived stem cells ; cGMP ; cyclic guanosine monophosphate ; cNOS ; constitutive nitric oxide synthase ; ED ; erectile dysfunction ; FDA ; USA Food and Drug Administration ; (hUCB-)MSCs ; (human umbilical cord blood) mesenchymal stem cells ; ICI ; intracavernosal injection ; LI-ESWT ; low-intensity extracorporeal shockwave therapy ; NO ; nitric oxide ; PDE5Is ; phosphodiesterase type 5 inhibitors ; RP ; radical prostatectomy ; SC ; stem cell ; sGC ; soluble guanylate cyclase ; VED ; vacuum erectile

刊名：Arab Journal of Urology

出版年：2016

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