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在“Elsevier电子期刊”中，命中：45条，耗时：0.011994 秒

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1.Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines

作者：Michiel W. den Braver ; Shalenie P. den Braver-Sewradj ; Nico P.E. Vermeulen ; Jan N.M. Commandeur ; ^{j.n.m.commandeur@vu.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：DF ; diclofenac ; 4&prime ; -OH-DF ; 4&prime ; -hydroxy-diclofenac ; 5-OH-DF ; 5-hydroxy-diclofenac ; 4&prime ; 5-diOH-DF ; 4&prime ; 5-dihydroxy-diclofenac ; DF-1&prime ; 4&prime ; -QI ; diclofenac-1&prime ; 4&prime ; -quinone imine ; DF-2 ; 5-QI ; diclofenac-2 ; 5-quinone imine ; M1 ; 4-glutathion-S-yl-5-hydroxy-diclofenac) ; M2 ; 3&prime ; -glutathion-S-yl-4-hydroxy-diclofenac ; M3 ; 6-glutathion-S-yl-5-hydroxy-diclofenac ; M5 ; 2-glutathion-S-yl-4-hydroxy-deschlorodiclofenac ; CYPs ; cytochrome P450s ; GST ; glutathione S-transfera

刊名：Toxicology Letters

出版年：2016

2.Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol

作者：Michiel W. den Braver ; Yongjie Zhang ; Harini Venkataraman ; Nico P.E. Vermeulen ; Jan N.M. Commandeur ; ^{j.n.m.commandeur@vu.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：CDNB ; 1-chloro-2 ; 4-dinitrobenzene ; EPNP ; 1 ; 2-epoxy-3-(p-nitrophenoxy)propane ; M5 ; 2&prime ; -glutathion-S-yl-4&prime ; -hydroxy-deschlorodiclofenac ; M2 ; 3&prime ; -glutathion-S-yl-4-hydroxy-diclofenac ; M1 ; 4-glutathion-S-yl-5-hydroxy-diclofenac ; 4&prime ; -OH-DF ; 4&prime ; -hydroxy-diclofenac ; 5-OH-DF ; 5-hydroxy-diclofenac ; M3 ; 6-glutathion-S-yl-5-hydroxy-diclofenac ; CYP ; cytochrome P450 ; DF ; diclofenac ; DF-1&prime ; 4&prime ; -QI ; diclofenac-1&prime ; 4&prime ; -benzoquinone imine ; DF-2 ; 5-Q ; Idiclofenac-2 ; 5-be

刊名：Toxicology Letters

出版年：2016

3.Elucidation of biotransformation of diclofenac and 4′hydroxydiclofenac during biological wastewater treatment

作者：Helene Bouju^a ; Peter Nastold^a ; Birgit Beck^b ; Juliane Hollender^b ; Philippe F.-X. Corvini^a ; ^c ; Thomas Wintgens^a ; ^{thomas.wintgens@fhnw.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：AU ; arbitrary unit ; AGC ; automatic gain control ; DF ; diclofenac ; NSAID ; non-steroidal anti-inflammatory drugs ; LOEC ; lowest observed effect concentration ; HRT ; hydraulic retention time ; SRT ; solids retention time ; 4&prime ; -OHDF ; 4&prime ; -hydroxydiclofenac ; LC-ToF-MS ; liquid chromatography with time-of-flight mass spectrometry ; HRMS ; high resolution mass spectrometry ; MBR ; membrane bioreactor ; WWTP ; wastewater treatment plant ; LSC ; liquid scintillation counting analyser ; DAD ; diode array detectio

刊名：Journal of Hazardous Materials

出版年：2016

4.Modeling of aceclofenac metabolism to major metabolites in healthy volunteers

作者：Eunyoung Kim^a ; Chunhwa Ihm^b ; Wonku Kang^a ; ^{wkang@cau.ac.kr}

关键词：Aceclofenac ; Metabolism ; 4&prime ; -Hydroxydiclofenac ; Diclofenac ; 4&prime ; -Hydroxydiclofenac ; Pharmacokinetic modeling ; Human

刊名：Drug Metabolism and Pharmacokinetics

出版年：2016

5.Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α

作者：Houssein Al-Attrache^a ; ^b ; ^d ; Ahmad Sharanek^a ; ^b ; Audrey Burban^a ; ^b ; Matthew Burbank^a ; ^b ; Thomas Gicquel^a ; ^b ; ^c ; Ziad Abdel-Razzak^d ; Christiane Guguen-Guillouzo^a ; ^b ; Isabelle Morel^a ; ^b ; ^c ; André ; Guillouzo^a ; ^b ; ^{Andre.Guillouzo@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：ABT ; 1-aminobenzotriazole ; Ac-DEVD-AMC ; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin ; AC-IETD-AMC ; Ac-Ile-Glu-Thr-Asp-7-amino-4-methylcoumarin ; AC-LEHD-AMC ; Ac-Leu-Glu-His-Asp-7-Amino-4-methylcoumarin ; BSEP ; bile salt export pump ; CDF ; 5 (and 6)-carboxy-2&prime ; 7&prime ; -dichlorofluorescein (CDF) ; CRP ; C-reactive protein ; CYP ; cytochrome P450 ; DCF ; diclofenac ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; H2-DCFDA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein ; HO1 ; heme oxygenase 1

刊名：Toxicology Letters

出版年：2016

6.Allosteric activation of midazolam CYP3A5 hydroxylase activity by icotinib - Enhancement by ketoconazole

作者：XiaoMei Zhuang^a ; ^{xiaomeizhuang@163.com" class="auth_mail" title="E-mail the corresponding author} ; TianHong Zhang^a ; SiJia Yue^b ; Juan Wang^a ; Huan Luo^a ; YunXia Zhang^a ; Zheng Li^a ; JinJing Che^a ; HaiYing Yang^a ; Hua Li^a ; MingShe Zhu^c ; Chuang Lu^d ; ^{chuang.lu@biogen.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ICO ; icotinib (PubChem CID ; 22024915) ; MDZ ; midazolam (PubChem CID ; 4192) ; KTZ ; ketoconazole (PubChem CID ; 456201) ; 1&prime ; -OH-MDZ ; 1&prime ; -hydroxy-midazolam (PubChem CID ; 107917) ; 4-OH-MDZ ; 4-hydroxy-midazolam (PubChem CID ; 124449) ; TST ; testosterone (PubChem CID ; 6013) ; NIF ; nifedipine (PubChem CID ; 4458) ; Phenacetin (PubChem CID ; 4754) ; Bupropion (PubChem CID ; 444) ; Amodiaquine (PubChem CID ; 2165) ; Diclofenac (PubChem CID ; 3033) ; S-mephenytoin (PubChem CID ; 107921) ; Dextromethorphan (PubChe

刊名：Biochemical Pharmacology

出版年：2016

7.Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI)

作者：Muzeeb Syed^a ; ^{muzeeb.syed@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Christian Skonberg^b ; Steen Honoré ; Hansen^a

关键词：Oxidative phosphorylation ; ATP ; Drug induced liver injury ; Rat liver mitochondria ; Diclofenac ; Metabolites

刊名：Toxicology in Vitro

出版年：2016

8.Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

作者：Shalenie P. den Braver-Sewradj^a ; Michiel W. den Braver^a ; Nico P.E. Vermeulen^a ; Jan N.M. Commandeur^a ; Lysiane Richert^b ; ^c ; J. Chris Vos^a ; ^{j.c.vos@vu.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：4&prime ; -OH DF ; 4&prime ; -hydroxy diclofenac ; 5-OH DF ; 5-hydroxy diclofenac ; 7-HC ; 7-hydroxycoumarin ; APAP ; acetaminophen ; CYP ; cytochrome P450 ; DMEM ; Dulbecco's modified Eagle's medium ; DF ; diclofenac ; OH-TC ; hydroxy tolcapone ; TC ; tolcapone ; GST ; glutathione-S-transferase ; PBS ; phosphate-buffered saline ; SULT ; sulfotransferase ; UGT ; UDP glucuronosyltransferase

刊名：Toxicology in Vitro

出版年：2016

9.Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation

关键词：AA ; Arachidonic acid ; ANOVA ; Analysis of variance ; COX ; Cyclooxygenase ; DCFH-DA ; 2&prime ; 7&prime ; -Dichlorodihydrofluorescein diacetate ; g ; Gram ; HPLC ; High performance liquid chromatography ; IL-1 and -6 ; Interleukin -1 and -6 ; LOX ; Lipoxygenase ; LTB4 ; Leukotriene B4 ; mL ; Milliliter ; NDGA ; Nordihydroguaiaretic acid ; NMRI ; Naval Medical Research Institute ; ns ; Non-significant ; NSAIDS ; Non-steroidal anti-inflammatory drugs ; O. dillenii ; Opuntia dillenii ; PGB2 ; Prostaglandin B2 ; PGE2 ; Prostaglandi

刊名：Journal of Ethnopharmacology

出版年：2016

10.Cross-linked carbon nanotubes-based biocatalytic membranes for micro-pollutants degradation: Performance, stability, and regeneration

作者：Chao Ji^a ; ^b ; Jingwei Hou^a ; ^{Jingwei.hou@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Vicki Chen^a ; ^b

关键词：ABTS ; 2 ; 2&prime ; -Azino-bis-(3-ethyl benzothiazoline-6-sulfonic acid) ; BET ; Brunauer ; Emmett ; and Teller ; BJH ; Barrett ; Joyner and Halenda ; BPA ; bisphenol-A ; CA ; clofibric acid ; CBZ ; carbamazepine ; CNTs ; carbon nanotubes ; DCF ; diclofenac ; EDC ; N-(3-Dimethylaminopropyl)-N&prime ; -ethylcarbodiimide hydrochloride ; EMR ; enzymatic membrane reactor ; GLU ; glutaraldehyde ; HCl ; hydrochloric acid ; HPLC ; high performance liquid chromatography ; IBF ; ibuprofen ; LAC ; laccase ; MES ; 2-(N-Morpholino) ethanesulfoni

刊名：Journal of Membrane Science

出版年：2016

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