搜索页_ dipeptidyl peptidase 4 inhibitor (DPP-4)

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1.The effects of DPP-4 inhibitor on hypoxia-induced apoptosis in human umbilical vein endothelial cells

作者：Akari Nagamine^a ; Hiroshi Hasegawa^b ; Naoko Hashimoto^a ; Tomoko Yamada-Inagawa^a ; Masanori Hirose^b ; Yuka Kobara^b ; Hiroyuki Tadokoro^b ; Yoshio Kobayashi^b ; Hiroyuki Takano^a ; ^{htakano-cib@umin.ac.jp}

关键词：Endothelial cell ; Dipeptidyl peptidase-4 ; Apoptosis ; Hypoxia

刊名：Journal of Pharmacological Sciences

出版年：2017

2.Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

作者：Tsuyoshi Yanagimachi¹ ; Yukihiro Fujita¹ ; ^{yfujita@asahikawa-med.ac.jp} ; Yasutaka Takeda¹ ; Jun Honjo¹ ; Hidemitsu Sakagami¹ ; Hiroya Kitsunai¹ ; Yumi Takiyama¹ ; Atsuko Abiko¹ ; Yuichi Makino¹ ; Timothy J. Kieffer² ; Masakazu Haneda¹

关键词：Receptor-mediated incretin bioassays ; Glucose-dependent insulinotropic polypeptide ; Glucagon-like peptide-1 ; Dipeptidyl peptidase-4

刊名：Molecular Metabolism

出版年：2017

3.Effects of alogliptin on fractional flow reserve evaluated by coronary computed tomography angiography in patients with type 2 diabetes: Rationale and design of the TRACT study

作者：Tsuyoshi Nozue ; MD^a ; ^{nozue2493@yahoo.co.jp} ; Kazuki Fukui ; MD^b ; Takeshi Takamura ; MD^c ; Takashi Sozu ; PhD^d ; Kiyoshi Hibi ; MD ; FJCC^e ; Satoru Kishi ; MD^f ; Ichiro Michishita ; MD ; FJCC^a

关键词：Alogliptin ; Coronary atherosclerosis ; Coronary computed tomography angiography ; Dipeptidyl peptidase-4 inhibitor ; Fractional flow reserve

刊名：Journal of Cardiology

出版年：2017

4.A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems

作者：Li-Wei Zou^a ; ^b ; ¹ ; Ping Wang^a ; ¹ ; Xing-Kai Qian^a ; Lei Feng^c ; Yang Yu^a ; Dan-Dan Wang^a ; Qiang Jin^a ; Jie Hou^c ; Zhi-Hong Liu^d ; Guang-Bo Ge^a ; ^{geguangbo@dicp.ac.cn} ; Ling Yang^b ; ^{ylingdicp@gmail.com}

关键词：Dipeptidyl peptidase IV ; Two-photon fluorescent probe ; Cells and tissues imaging ; Inhibitor screening

刊名：Biosensors and Bioelectronics

出版年：2017

5.Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia

作者：Thomas Nyströ ; m^a ; Johan Bodegard^b ; ^{johan.bodegard@astrazeneca.com} ; David Nathanson^a ; Marcus Thuresson^c ; Anna Norhammar^d ; ^e ; Jan W. Eriksson^f

关键词：Insulin ; Type 2 diabetes ; Dipeptidyl peptidase-4 inhibitor ; Cardiovascular disease ; Hypoglycemia ; Outcome

刊名：Diabetes Research and Clinical Practice

出版年：2017

6.Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model

作者：Maimaiti Yisireyili^a ; Kyosuke Takeshita ; MD ; PhD ; FAHA^a ; ^b ; ^{kyousuke@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} (A/Prof.) ; Motoharu Hayashi^a ; Hongxian Wu^a ; Yasuhiro Uchida^a ; Koji Yamamoto^c ; Ryosuke Kikuchi^b ; Chang-Ning Hao^a ; Takayuki Nakayama^e ; Xian Wu Cheng^a ; Tadashi Matsushita^b ; ^c ; Shigeo Nakamura^d ; Toyoaki Murohara^a

关键词：8-OHdG ; 8-hydroxy-deoxyguanosine ; DPP-4 ; dipeptidyl peptidase-4 ; GLP-1 ; glucagon-like peptide-1 ; IL-6 ; interleukin-6 ; MCP-1 ; monocyte chemoattractant protein-1 ; MetS ; metabolic syndrome ; NPYN ; neuropeptide Y ; PAI-1 ; plasminogen activator inhibitor-1 ; RAS ; renin-angiotensin system ; ROS ; reactive oxygen species ; SNS ; sympathetic nervous system ; TF ; tissue factor ; TNF-α ; tumor necrosis factor-α ; VAT ; visceral adipose tissue

刊名：Psychoneuroendocrinology

出版年：2016

7.A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

作者：Shinichiro Kimura^a ; Toyoshi Inoguchi^a ; ^b ; ^{toyoshi@intmed3.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Toshihide Yamasaki^c ; Mayumi Yamato^b ; Makoto Ide^a ; Noriyuki Sonoda^a ; ^b ; Kenichi Yamada^c ; Ryoichi Takayanagi^a

关键词：DPP-4 ; dipeptidyl peptidase-4 ; GLP-1 ; glucagon-like peptide-1 ; · ; OH ; hydroxyl-radical ; O2&minus ; superoxide ; ESR ; electron spin resonance ; 8-OHdG ; 8-hydroxy-2&prime ; -deoxyguanosine ; XOD ; xanthine oxidase ; DMPO ; 5.5-dimethyl-l-pyrroline-N-oxide ; HPX ; hypoxanthine ; TLC ; thin-layer chromatography ; HRMS ; high-resolution mass spectrometry ; F344 ; Fischer 344 ; STZ ; streptozotocin ; ELISA ; enzyme-linked immunosorbent assay ; IC50 ; half maximal inhibitory concentration ; ROS ; reactive oxygen species

刊名：Metabolism

出版年：2016

8.Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis

作者：Huai Heng Loh^a ; ^{hh_loh@yahoo.com.my" class="auth_mail" title="E-mail the corresponding author} ; Anne Yee^b ; Huai Seng Loh^c ; Norlela Sukor^d ; Nor Azmi Kamaruddin^d

关键词：Dipeptidyl peptidase-4 inhibitor ; Ramadan fasting ; Sulphonylurea ; Type 2 diabetes mellitus

刊名：Primary Care Diabetes

出版年：2016

9.Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate

作者：Dong-Sung Lee^a ; Eun-Sol Lee^b ; ^c ; Md. Morshedul Alam^d ; Jun-Hyeog Jang^e ; Ho-Sub Lee^c ; ^f ; Hyuncheol Oh^c ; ^g ; Youn-Chul Kim^b ; ^c ; ^g ; Zahid Manzoor^h ; Young-Sang Koh^h ; Dae-Gil Kang^c ; ^f ; ^{dgkang@wonkwang.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Dae Ho Lee^c ; ⁱ ; ^{drhormone@naver.com" class="auth_mail" title="E-mail the corresponding author} ; ^{drdhkso@hanmail.net" class="auth_mail" title="E-mail the corresponding author}

关键词：BMDM ; bone-marrow-derived macrophage ; DPP-4 ; dipeptidyl peptidase-4 ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; IκB-α ; NF-kappa-B inhibitor alpha ; iNOS ; inducible nitric oxide synthase ; LPS ; lipopolysaccharide ; M6P ; mannose-6-phosphate ; NO ; nitric oxide ; PKC ; protein kinase C ; sDPP-4 ; soluble DPP-4 ; SMCs ; smooth muscle cells ; TLR ; toll-like receptor

刊名：Metabolism

出版年：2016

10.DPP-4 inhibitor therapy and bone fractures in people with Type 2 diabetes - A systematic review and meta-analysis

作者：Jil Mamza^a ; Carol Marlin^a ; Cai Wang^a ; Kamal Chokkalingam^b ; Iskandar Idris^a ; ^{Iskandar.Idris@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Fracture ; Dipeptidyl peptidase-4 inhibitor ; Meta-analysis

刊名：Diabetes Research and Clinical Practice

出版年：2016

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