作者：Lisa A. Stott^a ; David A. Hall^b ; Nicholas D. Holliday^a ; ^{nicholas.holliday@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：CRC ; concentration response curve ; EC50 ; effective agonist concentration for 50% maximum response ; Emax ; maximum system response ; GPCR ; G protein coupled receptor ; D2R ; dopamine D2 receptor ; GTPγS ; guanosine 5&prime ; -O-[γ-thio]triphosphate ; KA ; agonist equilibrium dissociation constant ; KE ; concentration of agonist&ndash ; receptor complex which produces a half maximal effect ; MAPK ; mitogen activated protein kinase ; RAi ; relative intrinsic activity ratio ; Rmax ; maximum agonist response ; RT ; total

刊名：Biochemical Pharmacology

出版年：2016

作者：Milan Stoiljkovic^a ; ^{milan.stoiljkovic@yale.edu" class="auth_mail" title="E-mail the corresponding author} ; Liza Leventhal^b ; ^{lleventhal@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Angela Chen^b ; ^{achen@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Ting Chen^b ; ^{tchen@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Rachelle Driscoll^b ; ^{rdriscoll@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Dorothy Flood^b ; ^{dflood@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Hilliary Hodgdon^b ; ^{hhodgdon@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Raymond Hurst^b ; ^{rhurst@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; David Nagy^a ; ^{david.nagy@yale.edu" class="auth_mail" title="E-mail the corresponding author} ; Timothy Piser^b ; ^{tpiser@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Cuyue Tang^b ; ^{ctang@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Matthew Townsend^b ; ^{mtownsend@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Zhiming Tu^b ; ^{ztu@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Daniel Bertrand^c ; ^{daniel.bertrand@hiqscreen.com" class="auth_mail" title="E-mail the corresponding author} ; Gerhard Koenig^b ; ^{gkoenig@forumpharma.com" class="auth_mail" title="E-mail the corresponding author} ; Mihaly Hajó ; s^a ; ^{mihaly.hajos@yale.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ACh ; acetylcholine ; aCSF ; artificial cerebrospinal fluid ; AP ; anterior posterior ; AP5 ; (2R)-amino-5-phosphonopentanoate ; AUC ; area under the concentration-time curve ; CHO ; Chinese hamster ovary ; Cmax ; maximum concentration ; Cu ; brain ; unbound brain concentration ; DMSO ; dimethyl sulfoxide ; EEG ; electroencephalogram ; EVP-6124 (encenicline) ; (R)-7-chloro-N-quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide ; fEPSP ; field excitatory postsynaptic potential ; FRM-17874 ; (R)-7-fluoro-N-quinuclidin-3-yl)benz

刊名：Biochemical Pharmacology

出版年：2015

作者：Thiago Bruder-Nascimento^a ; Benjamin R. Butler^a ; David J. Herren^a ; Michael W. Brands^a ; Kendra K. Bence^b ; Eric J. Belin de Chantemè ; le^a ; ^{ebelindechanteme@gru.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：5HT ; 5-hydroxytryptamine ; ACh ; acetylcholine ; BP ; blood pressure ; DBP ; diastolic blood pressure ; Emax ; maximum possible effect ; Jak-2 ; janus kinase-2 ; l-NAME ; N-nitro-l-arginine methyl ester ; MAP ; mean arterial pressure ; NOS ; nitric oxide synthase ; Phe ; phenylephrine ; pD2 ; potency of the agonist (negative logarithm to base 10 of the half maximal effective concentration ; EC50) ; POMC ; proopiomelanocortin ; Ptp1b ; protein tyrosine phosphatase 1b ; RQ ; respiratory quotient (ratio VCO2 to VO2) ; SBP ; sy

刊名：Pharmacological Research

出版年：2015

作者：Erin H. Caulder ; Melissa A. Riegle ; Dwayne W. Godwin

关键词：AED ; antiepileptic drug ; C/T ; clonic/tonic ; EEG ; electroencephalography ; EMG ; electromyography ; mGluR ; metabotropic glutamate receptor ; PAM ; positive allosteric modulator ; SE ; status epilepticus ; SRS ; spontaneous recurrent seizures ; TLE ; temporal lobe epilepsy

刊名：Epilepsy Research

出版年：February, 2014

作者：Amanda Oliver ; MBBS ; MRCP ; FFPM¹ ; ^{Amanda.j.oliver@gsk.com" class="auth_mail} ; Sandi VanBuren ; RN² ; Ann Allen ; BSc (Hons)³ ; Melanie Hamilton ; BSc (Hons)⁴ ; Lee Tombs ; MSc⁵ ; Amir Inamdar ; MBBS¹ ; ^* ; Rodger Kempsford ; PhD³

关键词：ICS ; LABA ; pediatric ; pharmacodynamics ; pharmacokinetics ; tolerability

刊名：Clinical Therapeutics

出版年：1 June 2014

作者：D. Steckler ; V. Naidoo ; D. Gerber ; W. K?hn

关键词：Equine myometrium ; Oxytocin ; Carbetocin ; Ex vivo ; Organ bath

刊名：Theriogenology

出版年：2012

作者：Jaymin Upadhyay^a ; ^b ; Julie Anderson^a ; ^b ; Richard Baumgartner^a ; ^c ; Alexandre Coimbra^a ; ^c ; Adam J. Schwarz^a ; ^d ; Gautam Pendse^a ; ^b ; Diana Wallin^a ; ^b ; Lauren Nutile^a ; ^b ; James Bishop^a ; ^b ; Edward George^a ; ^b ; Igor Elman^e ; Soujanya Sunkaraneni^a ; ^f ; Gary Maier^a ; ^f ; Smriti Iyengar^a ; ^d ; Jeffrey L. Evelhoch^a ; ^c ; David Bleakman^a ; ^d ; Richard Hargreaves^a ; ^c ; Lino Becerra^a ; ^b ; ^f ; David Borsook^a ; ^b ; ^f ; ^{dborsook@partners.org}

关键词：Buprenorphine ; Analgesia ; Evoked pain fMRI ; Functional connectivity ; Putamen

刊名：NeuroImage

出版年：2012

作者：Mabayoje A.  ; Oriowo^a ;   ; ^{Oriowo@hsc.edu.kw} ; Elsie  ; Oommen^a ; Islam  ; Khan^b

关键词：Pulmonary artery ; Thyroxine ; 5-HT ; Niflumic acid ; Nifedipine ; Ketanserin

刊名：European Journal of Pharmacology

出版年：2011

作者：Wayne H.-H. Sheu ; Hsiu-Chun Chuang ; Shiu-Min Cheng ; Maw-Rong Lee ; Chi-Chi Chou ; Fu-Chou Cheng

关键词：Glucose ; Ischemia ; Liquid chromatography– ; mass spectrometry/mass spectrometry ; Microdialysis ; Rosiglitazone

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2011

作者：Regina G.D.M. van Kleef ; Henk P.M. Vijverberg ; Remco H.S. Westerink

关键词：Xenopus oocyte ; Ototoxicity ; Two-electrode voltage cl Xylene ; Ethylbenzene

刊名：Toxicology in Vitro

出版年：2008