搜索页_ growth factors/antagonists and inhibitors

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在“Elsevier电子期刊”中，命中：8,793条，耗时：0.1079222 秒

在所有数据库中总计命中：14,360条

1.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR

作者：Mohamed M. Mohyeldin ^{mohyelmm@warhawks.ulm.edu} ; Mohamed R. Akl ^{mohamedreda_pharmacy@yahoo.com} ; Abu Bakar Siddique ; Hossam M. Hassan¹ ; ^{abuh20050@yahoo.com} ; Khalid A. El Sayed ; ^{elsayed@ulm.edu}

关键词：ATCC ; American type culture collection ; CD30 ; cluster of differentiation 30 a type I transmembrane glycoprotein belonging to the TNF receptor superfamily ; CD31 ; platelet endothelial cell adhesion molecule 1 ; EGF ; epidermal growth factor ; EPHB4 ; ephrin type-B receptor 4 ; ERK ; extracellular signal-regulated kinase ; FGFR ; fibroblast growth factor receptor ; FLT3 ; fms-related tyrosine kinase 3 ; JAK2 ; janus kinase 2 ; L858R ; leucine 858 mutated to arginine ; L861Q ; leucine 861 mutated to glutamine ; M ; m

刊名：Biochemical Pharmacology

出版年：2017

2.Structure-guided development of covalent TAK1 inhibitors

作者：Li Tan^a ; ^b ; ^j ; Deepak Gurbani^c ; ^d ; ^j ; Ellen L. Weisberg^e ; ^f ; John C. Hunter^c ; ^d ; Lianbo Li^c ; ^d ; Douglas S. Jones^g ; ^h ; Scott B. Ficarro^a ; ^b ; Samar Mowafy^a ; ^b ; ⁱ ; Chun-Pong Tam^a ; ^b ; Suman Rao^a ; ^b ; ^g ; Guangyan Du^a ; ^b ; James D. Griffin^e ; ^f ; Peter K. Sorger^g ; Jarrod A. Marto^a ; ^b ; Kenneth D. Westover^c ; ^d ; ^{Kenneth.Westover@UTSouthwestern.edu} ; Nathanael S. Gray^a ; ^b ; ^{Nathanael_Gray@dfci.harvard.edu}

关键词：Structure-based design ; TAK1 kinase inhibitors ; Covalent inhibitors ; 2 ; 4-Disubstituted pyrimidine ; Structure-activity relationship

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27

作者：Ying Huang^a ; ¹ ; Renyi Wu^a ; ¹ ; Zheng-Yuan Su^a ; ^c ; Yue Guo^a ; Xi Zheng^b ; Chung S. Yang^b ; Ah-Ng Kong^a ; ^{KongT@pharmacy.rutgers.edu}

关键词：T3 ; tocotrienol ; T ; tocopherol ; HDAC ; histone deacetylase ; HAT ; histone acetyltransferase ; CDK ; cyclin-dependent kinase

刊名：The Journal of Nutritional Biochemistry

出版年：2017

4.Targeting GH-1 splicing as a novel pharmacological strategy for growth hormone deficiency type II

作者：Maria Consolata Miletta ; ^{maria.miletta@dkf.unibe.ch} ; Christa E. Flü ; ck ; Primus-E. Mullis

关键词：Growth hormone ; GH-1 gene ; Short stature ; Growth hormone deficiency type II ; Splicing modulation

刊名：Biochemical Pharmacology

出版年：2017

5.Synthesis, biological evaluation, QSAR and molecular dynamics simulation studies of potential fibroblast growth factor receptor 1 inhibitors for the treatment of gastric cancer

作者：Shilong Ying^a ; ¹ ; Xiaojing Du^a ; ^b ; ¹ ; Weitao Fu^a ; ¹ ; Di Yun^a ; Liping Chen^a ; Yuepiao Cai^a ; Qing Xu^c ; Jianzhang Wu^a ; ^{wjzwzmu@163.com} ; Wulan Li^a ; ^d ; ^{lwlwzmu@163.com} ; Guang Liang^a

关键词：Design ; Fibroblast growth factor receptor 1 ; Gastric cancer ; Quantitative structure-activity relationship

刊名：European Journal of Medicinal Chemistry

出版年：2017

6.Phase 2 Study of Erlotinib in Combination With Linsitinib (OSI-906) or Placebo in Chemotherapy-Naive Patients With Non-Small-Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations

作者：Natasha B. Leighl¹ ; Naiyer A. Rizvi² ; Lopes Gilberto de Lima Jr.³ ; ⁴ ; Wichit Arpornwirat⁵ ; Charles M. Rudin⁶ ; Alberto A. Chiappori⁷ ; Myung-Ju Ahn⁸ ; Laura Q.M. Chow⁹ ; Lyudmila Bazhenova¹⁰ ; Arunee Dechaphunkul¹¹ ; Patrapim Sunpaweravong¹² ; Keith Eaton¹³ ; ¹⁴ ; Jihong Chen¹⁵ ; Sonja Medley¹⁵ ; Srinivasu Poondru¹⁵ ; Margaret Singh¹⁵ ; Joyce Steinberg¹⁵ ; Rosalyn A. Juergens¹⁶ ; ^{juergensr@hhsc.ca} ; Shirish M. Gadgeel¹⁷ ; ¹⁸

关键词：Combination ; Epidermal growth factor receptor inhibitor ; First-line therapy ; Insulin-like growth factor-1 inhibitor ; Tyrosine kinase inhibitor

刊名：Clinical Lung Cancer

出版年：2017

7.Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: A systematic review and meta-analysis

作者：Husam Abdel-Qadir^a ; ^b ; ^c ; ^d ; ^{h.abdel.qadir@mail.utoronto.ca} ; Josee-Lyne Ethier^a ; ^e ; Douglas S. Lee^a ; ^b ; ^c ; ^f ; Paaladinesh Thavendiranathan^a ; ^f ; Eitan Amir^a ; ^c ; ^e

关键词：Antineoplastic agents/adverse effects ; Angiogenesis inhibitors ; Cardiotoxins ; Vascular endothelial growth factor ; Bevacizumab ; Sorafenib ; Sunitinib ; Vandetanib ; Aflibercept

刊名：Cancer Treatment Reviews

出版年：2017

8.Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2

作者：Kurnvir Singh^a ; Rose Tanui^a ; Armanda Gameiro^a ; ¹ ; Gilad Eisenberg^a ; Claire Colas^b ; Avner Schlessinger^b ; Christof Grewer^a ; ^{cgrewer@binghamton.edu}

关键词：Neutral amino acid transporter ; ASCT2 ; Inhibitors ; Glutamine transport ; Kinetics ; Patch clamp ; Pharmacology

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

9.Intercalated Chemotherapy and Epidermal Growth Factor Receptor Inhibitors for Patients With Advanced Non-Small-cell Lung Cancer: A Systematic Review and Meta-analysis

作者：Anna La Salvia¹ ; Antonio Rossi² ; ^{arossi_it@yahoo.it} ; Domenico Galetta³ ; Elisa Gobbini¹ ; Emmanuele De Luca¹ ; Silvia Novello¹ ; Massimo Di Maio¹

关键词：Afatinib ; Erlotinib ; Gefitinib ; Mutation ; NSCLC

刊名：Clinical Lung Cancer

出版年：2017

10.24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei

作者：Matthew B. Miller^a ; ¹ ; Presheet Patkar^a ; ¹ ; Ujjal K. Singha^b ; Minu Chaudhuri^b ; W. David Nes^a ; ^{wdavid.nes@ttu.edu}

关键词：HAT ; Human African trypanosomiasis ; SAM ; S-adenosyl-l-methionine ; BSF ; blood stream form ; PCF ; procyclic form ; DHL ; 26-dehydrolanosterol ; DHZ ; 26-dehydrozymosterol ; HEK ; human epithelial cells ; TbSMT ; Trypanosoma brucei sterol methyltransferase ; ED ; effective doses ; GC&ndash ; MS ; gas chromatography&ndash ; mass spectroscopy ; RRTc ; relative retention time with cholesterol used as standard

刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

出版年：2017

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