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Elsevier电子期刊(32)

在“Elsevier电子期刊”中，命中：32条，耗时：0.0649686 秒

在所有数据库中总计命中：43条

1.Bis(N-amidinohydrazones) and N-(amidino)-N′-aryl-bishydrazones: New classes of antibacterial/antifungal agents

作者：Sanjib K. Shrestha^a ; Liliia M. Kril^a ; ^b ; Keith D. Green^a ; Stefan Kwiatkowski^b ; ^d ; Vitaliy M. Sviripa^b ; ^c ; Justin R. Nickell^a ; Linda P. Dwoskin^a ; David S. Watt^b ; ^c ; ^d ; ^{dwatt@uky.edu} ; Sylvie Garneau-Tsodikova^a ; ^{sylviegtsodikova@uky.edu}

关键词：Bishydrazones ; Candida albicans ; Cytotoxicity ; hERG channel ; Resistance ; Staphylococcus aureus

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging

作者：Graham T. Dempsey^a ; Khuram W. Chaudhary^b ; ^{khuram.w.chaudhary@gsk.com" class="auth_mail" title="E-mail the corresponding author} ; Nicholas Atwater^a ; Cuong Nguyen^a ; Barry S. Brown^b ; John D. McNeish^c ; Adam E. Cohen^d ; ^e ; ^f ; Joel M. Kralj^a

关键词：CiPA ; Comprehensive in vitro Proarrhythmia Assay ; TdP ; Torsades de Pointes ; AP ; action potential ; CT ; Ca2 ; + transient ; hiPSC ; human induced pluripotent stem cell ; CM ; cardiomyocyte ; CaViar ; Ca2 ; + and voltage indicator ; CheRiff ; channelrhodopsin variant ; EAD ; early after depolarization ; ECG ; electrocardiogram ; hERG ; human Ether-&agrave ; -go-go-Related Gene ; MEA ; multi-electrode array ; Arch ; Archaerhodopsin ; VSD ; voltage sensitive dye

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

3.The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

关键词：APD ; action potential duration ; AERS ; adverse event reporting system ; CiPA ; Comprehensive in Vitro Proarrhythmia Assay ; EAD ; early after depolarizations ; ECG ; electrocardiogram ; HESI ; Health and Environmental Sciences Institute ; HT ; high throughput ; hSC-CM ; human cardiac stem cell derived cardiomyocyte ; hERG or IKr ; human ether-&agrave ; -go-go related gene ; ISWG ; In Silico Working Group ; ICWG ; Ion Channel Working Group ; ICH ; International Conference on Harmonisation ; JiCSA ; Japan iPS Cardiac Safe

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

4.SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells

作者：Hui Liu^a ; ^c ; ¹ ; Lei Yang^b ; ^c ; ¹ ; Kui-Hao Chen^a ; ^c ; Hai-Ying Sun^c ; Man-Wen Jin^a ; Guo-Sheng Xiao^d ; Yan Wang^d ; ^{wy@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Gui-Rong Li^c ; ^d ; ^{grli8@outlook.com" class="auth_mail" title="E-mail the corresponding author}

关键词：SK-96365 (1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl) propoxy]ethyl]imidazole) (PubChem CID ; 104956) ; Dimethyl sulfoxide (PubChem CID ; 679) ; G418 sulfate (PubChem CID ; 86605443) ; Pentobarbital sodium (PubChem CID ; 23676152)

刊名：Pharmacological Research

出版年：2016

5.A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

作者：Zhihua Li ; ^{Zhihua.li@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Sara Dutta ; Jiansong Sheng ; Phu N. Tran ; Wendy Wu ; Thomas Colatsky

关键词：CiPA ; hERG ; Kv11.1 ; Markov model ; Methods ; Temperature

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

6.The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Henry Holzgrefe^b ; Mike Clements^c

关键词：AP ; cardiac action potential ; CiPA ; comprehensive in vitro proarrhythmia assay ; CSRC ; Cardiac Safety Research Consortium ; Cmax ; maximal plasma concentration ; CTWG ; clinical translational working group ; DRest ; rate-normalized Tpeak ; &minus ; ; Tend ; = ; Tpe interval ; ECG ; electrocardiogram ; E-R ; exposure-response ; FDA ; Food and Drug Administration ; FIH ; first-in-humans ; hERG ; human ether-&agrave ; -go-go-related gene ; hiPSC-CMs ; human induced pluripotent stem cell derived cardiomyocyte

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

7.Novel treatment strategies for smooth muscle disorders: Targeting Kv7 potassium channels

作者：Jennifer M. Haick ; Kenneth L. Byron ; ^{kbyron@luc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：COPD ; chronic obstructive pulmonary disease ; CPA ; chorionic plate artery ; FDA ; Food and Drug Administration ; hERG ; human Ether-&agrave ; -go-go related gene ; IBS ; irritable bowel syndrome ; PAH ; pulmonary arterial hypertension ; RT-PCR ; quantitative reverse transcriptase polymerase chain reaction ; VDCCs ; voltage-dependent calcium channels

刊名：Pharmacology and Therapeutics

出版年：2016

8.Ibogaine for treating drug dependence. What is a safe dose?

作者：L.J. Schep^a ; ^{leo.schep@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author} ; R.J. Slaughter^a ; S. Galea^b ; ^c ; D. Newcombe^c

关键词：Ibogaine ; Drug dependence ; QT prolongation ; Purkinje cells ; Potassium voltage gated human Ether-&agrave ; -go-go-Related gene (hERG) channel

刊名：Drug and Alcohol Dependence

出版年：2016

9.Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

作者：Yihong Zhang^a ; Charlotte K. Colenso^b ; ¹ ; Aziza El Harchi^a ; Hongwei Cheng^a ; Harry J. Witchel^c ; Chris E. Dempsey^b ; ^{C.Dempsey@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jules C. Hancox^a ; ^{Jules.hancox@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; diLQTS ; drug induced long QT syndrome ; DEA ; desethylamiodarone ; HEK ; human embryonic kidney ; hERG ; human-Ether-&agrave ; -go-go-Related Gene ; IC50 ; half-maximal inhibitory concentration ; IhERG ; ionic current carried by hERG potassium channels ; IKr ; rapid delayed rectifier potassium current ; IKs ; slow delayed rectifier potassium current ; LQTS ; long QT syndrome

刊名：Biochemical Pharmacology

出版年：2016

10.hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

作者：Akil Puckerin ; PhD^* ; Kelly A. Aromolaran ; PhD^&dagger ; ; Donald D. Chang ; PhD^* ; R. Suzanne Zukin ; PhD^&dagger ; ; Henry M. Colecraft ; PhD^* ; Mohamed Boutjdir ; PhD^&Dagger ; ; ^§ ; ; ^║ ; Ademuyiwa S. Aromolaran ; PhD^* ; ^{aa3000@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：hERG 1a ; hERG 1b ; KCNH2 ; IKr ; LQT2 ; HEK293 ; Cardiomyocytes ; Guinea pig ; Potassium channel ; Truncation mutants

刊名：Heart Rhythm

出版年：2016

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