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1.Feasibility of the functional expression of the human organic anion transporting polypeptide 1B1 (OATP1B1) and its genetic variant 521T/C in the mouse liver

作者：Yoon-Jee Chae^a ; Kyeong-Ryoon Lee^b ; Jong-Hwa Lee^c ; Wooin Lee^d ; Dae-Duk Kim^d ; Suk-Jae Chung^d ; ^{sukjae@snu.ac.kr} ; Han-Joo Maeng^e ; ^{hjmaeng@gachon.ac.kr}

关键词：ALP ; alkaline phosphatase ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; AUC ; the area under the plasma concentration-time curve ; CLapp ; hep ; hepatic uptake clearance ; hOATP1B1 ; human organic anion transporting polypeptide 1B1 ; HGD ; hydrodynamic gene delivery ; HMG-CoA ; 3-hydroxy-3-methylglutaryl ; IS ; internal standard ; LC-MS ; liquid chromatography-mass spectrometry ; mOATPs ; mouse organic anion transporting polypeptides ; RT-PCR ; reverse transcription-polymerase chain reaction ; S

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Levocetirizine transport by human organic anion transporter 4

作者：Saki Noguchi¹ ; Tomohiro Nishimura¹ ; Saya Mukaida¹ ; Masatoshi Tomi¹ ; Leslie Z. Benet² ; Emi Nakashima¹

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

3.Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2

作者：Haoxun Wang^a ; Da Xu^a ; May Fern Toh^a ; Alan C. Pao^b ; Guofeng You^a ; ^{gyou@rci.rutgers.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Organic anion transporter ; Drug transport ; Regulation ; Serum and glucocorticoid-inducible kinase ; Ubiquitin ligase ; Ubiquitination

刊名：Biochemical Pharmacology

出版年：2016

4.In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide

作者：Maria D. Donovan^a ; ^b ; Harrië ; t Schellekens^b ; ^c ; Geraldine B. Boylan^d ; ^e ; John F. Cryan^b ; ^c ; Brendan T. Griffin^a ; ^{brendan.griffin@ucc.ie" class="auth_mail" title="E-mail the corresponding author}

关键词：A&rarrB ; apical to basolateral ; B&rarrA ; basolateral to apical ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; DMEM ; Dulbecco's modified Eagle medium ; eGFP ; enhanced green fluorescent protein ; FACS ; fluorescence-activated cell sorting ; FBS ; foetal bovine serum ; fu plasma albumin ; fraction unbound in plasma albumin ; fu brain ; fraction unbound in brain ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HEK ; human embryonic kidney ; hOAT3 ; human organic anion transporter 3 ; HPLC ; high

刊名：European Journal of Pharmacology

出版年：2016

5.Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis

作者：Elisabeth G.D. Stribos^a ; ^b ; Theerut Luangmonkong^b ; ^c ; Anna M. Leliveld^d ; Igle J. de Jong^d ; Willem J. van Son^a ; Jan-Luuk Hillebrands^e ; Marc A. Seelen^a ; Harry van Goor^e ; Peter Olinga^b ; ^{p.olinga@rug.nl" class="auth_mail" title="E-mail the corresponding author} ; Henricus A.M. Mutsaers^b

关键词：ATP ; adenosine triphosphate ; BCRP ; breast cancer resistance protein ; CKD ; chronic kidney disease ; COL1A1 ; collagen type 1A1 ; ECM ; extracellular matrix ; ESRD ; end-stage renal disease ; FN1 ; fibronectin 1 ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; 7-HCG ; 7-hydroxycoumarin glucuronide ; HPLC ; high-performance liquid chromatography ; HSP47 ; heat shock protein 47 ; LDH ; lactate dehydrogenase ; OAT ; organic anion transporter ; OATP4C1 ; organic anion transporting polypeptide 4C1 ; PAI ; plasminogen acti

刊名：Translational Research

出版年：2016

6.l-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

作者：Kristiina M. Huttunen^a ; ^{Kristiina.Huttunen@uef.fi" class="auth_mail" title="E-mail the corresponding author} ; Johanna Huttunen^a ; Imke Aufderhaar^a ; Mikko Gynther^a ; William A. Denny^b ; Julie A. Spicer^b

关键词：BBB ; blood&ndash ; brain barrier ; CTLs ; cytotoxic T lymphocytes ; HPLC ; high-performance liquid chromatography ; LAT1 ; l-type amino acid transporter ; MCF-7 ; human breast adenocarcinoma cell line ; MCTs ; monocarboxylate transporters ; NK cells ; natural killer cells ; OATPs ; organic anion transporting polypeptides ; PSA ; polar surface area

刊名：International Journal of Pharmaceutics

出版年：2016

7.Renal drug transporters and their significance in drug-drug interactions

作者：Jia Yin ; Joanne Wang ; ^{jowang@uw.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ABC ; ATP-binding cassette ; ATP ; adenosine triphosphate ; AUC ; area under the plasma concentration curve ; BBB ; blood&ndash ; brain barrier ; Cmax ; maximum plasma concentration ; CHO ; Chinese hamster ovary ; CL ; plasma clearance ; CLR ; renal clearance ; DDIs ; drug&ndash ; drug interactions ; fe ; fraction of the absorbed dose excreted unchanged in urine ; FDA ; U.S. Food and Drug Administration ; GSH ; glutathione ; HEK ; human embryonic kidney ; IC50 ; half maximal inhibitory concentration ; ITC ; International Transp

刊名：Acta Pharmaceutica Sinica B

出版年：2016

8.Role of organic anion transporter 4 on the transport of olmesartan across the basal plasma membrane of human placental syncytiotrophoblast

作者：Masatoshi Tomi ; Saki Noguchi ; Ayasa Fujibayashi ; Tetsuo Maruyama ; Emi Nakashima ; Tomohiro Nishimura

刊名：Placenta

出版年：2016

9.Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1

作者：Lydia Aschauer^a ; Giada Carta^a ; Nadine Vogelsang^b ; Eberhard Schlatter^b ; Paul Jennings^a ; ^{Paul.Jennings@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author} ; ^{paul.other@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：4-Di-1-ASP ; 4-(4-(Dimethylamino)styryl)-N-Methylpyridinium Iodide ; CsA ; Cyclosporine A ; primary hPT ; human primary proximal tubule cells ; MATE ; multidrug and toxin extrusion proteins ; OAT ; organic anion transporter ; OATP ; organic anion polypeptide transporters ; OCT ; organic cation transporter ; PBPK ; physiologically based pharmacokinetic modelling ; RFU ; raw fluorescence unit ; TEER ; transepithelial electrical resistance

刊名：Toxicology in Vitro

出版年：2015

10.Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice

作者：Ming Wang^a ; Jing Zhao^b ; Nan Zhang^a ; Jianghua Chen^c ; ^{chenjianghua310@139.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Astilbin ; Potassium oxonate ; Hyperuricemia ; TXNIP ; Renal injury

刊名：Biomedicine & Pharmacotherapy

出版年：2016

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