搜索页_ inhibitor of κB (IκB) kinase

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1.IκB kinase inhibition as a potential treatment of osteoarthritis - results of a clinical proof-of-concept study

作者：K. Grothe^&dagger ; ; ^{Kirsten.Grothe@sanofi.com} ; K. Flechsenhar^&dagger ; ; ^{Klaus.Flechsenhar@sanofi.com} ; T. Paehler^&Dagger ; ; ^{Tobias.Paehler@sanofi.com} ; O. Ritzeler^§ ; ; ^{Olaf.Ritzeler@sanofi.com} ; J. Beninga^‖ ; ^{Jochen.Beninga@sanofi.com} ; J. Saas^&dagger ; ; ^{Joachim.Saas@sanofi.com} ; M. Herrmann^&dagger ; ; ^{Matthias.Herrmann@sanofi.com} ; K. Rudolphi^&dagger ; ; ^{Karl.Rudolphi@sanofi.com}

关键词：IκB kinase inhibitor ; Slow-release formulation ; Intra-articular injection ; Treatment of knee osteoarthritis ; Clinical findings

刊名：Osteoarthritis and Cartilage

出版年：2017

2.RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation

作者：Jae-Gyu Kim^a ; Hyung-Joo Kwon^b ; ^c ; Guang Wu^c ; Yohan Park^a ; Jae-Yong Lee^a ; ^d ; Jaebong Kim^a ; ^d ; Sung-Chan Kim^a ; ^d ; Myoen Choe^e ; Seung Goo Kang^f ; Goo-Young Seo^g ; Pyeung-Hyeun Kim^g ; Jae-Bong Park^a ; ^c ; ^d ; ^{jbpark@hallym.ac.kr}

关键词：CA ; constitutively active ; DMEM ; Dulbecco's modified Eagle's medium ; DN ; dominant negative ; GAP ; GTPase activating protein ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GDF ; GDI displacement factor ; GDI ; guanine nucleotide dissociation inhibitor ; GEF ; guanine nucleotide exchange factor ; GSH ; glutathione ; Rhotekin-RBD ; Rhotekin Rho-binding domain ; ROCK ; Rho-dependent coiled-coil kinase ; ROS ; reactive oxygen species ; WT ; wild-type ; NF-κB ; nuclear factor-κB ; IκB ; inhibitor of NF-κB ; IKK ; IκB ki

刊名：Free Radical Biology and Medicine

出版年：2017

3.Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling

作者：Yimeng Wang^a ; ^b ; Luguo Sun^b ; Zhenbo Song^a ; ^c ; Danfeng Wang^a ; ^b ; Yongli Bao^a ; ^{baoyl800@nenu.edu.cn} ; Yuxin Li^b ; ^c ; ^{liyx486@nenu.edu.cn}

关键词：Arg-1 ; arginase 1 ; CM ; conditioned medium ; FITC ; fluorescein isothiocyanate ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; iNOS ; inducible nitric oxide synthase ; IFN ; interferon ; IKK ; inhibitor of NF-κB kinase ; IκB ; inhibitor of NF-κB ; LPS ; lipopolysaccharide ; Mφ ; macrophage ; NBS ; neonatal bovine serum ; PDTC ; pyrrolidine dithiocarbamate ; rMaspin ; recombinant Maspin ; SEM ; standard error of the mean

刊名：Molecular Immunology

出版年：2017

4.Gamma irradiation enhanced Tollip-mediated anti-inflammatory action through structural modification of quercetin in lipopolysaccharide-stimulated macrophages

作者：Eui-Baek Byun^a ; ^b ; Beom-Su Jang^a ; ^b ; Hye-Min Kim^a ; ^d ; Mi-So Yang^c ; Nak-Yun Sung^d ; Eui-Hong Byun^d ; ^{ehbyun80@kongju.ac.kr}

关键词：HPLC ; high-performance liquid chromatography ; HRP ; horseradish peroxidase ; LPS ; lipopolysaccharide ; Tollip ; toll-interacting protein ; TLR ; toll-like receptor ; MHC ; major histocompatibility complex ; NF-κB ; nuclear factor-κB ; IκB ; inhibitor of κB ; TNF-α ; tumor necrosis factor-α ; IL ; interleukin ; MAPK ; mitogen-activated protein kinase ; COX ; cyclooxygenase ; iNOS ; nitric oxide synthase ; NO ; nitric oxide ; ELISA ; enzyme-linked immunosorbent assay ; PGE2 ; prostaglandin E2 ; ROS ; reactive oxygen species ; S

刊名：International Immunopharmacology

出版年：2017

5.Anti-inflammatory effect of the six compounds isolated from Nauclea officinalis Pierrc ex Pitard, and molecular mechanism of strictosamide via suppressing the NF-κB and MAPK signaling pathway in LPS-induced RAW 264.7 macrophages

作者：DongYu Li^a ; ^b ; ^c ; JiaQuan Chen^c ; JiQing Ye^d ; XiaoTing Zhai^a ; ^b ; ^c ; Jie Song^a ; ^b ; CuiHua Jiang^a ; ^e ; Jing Wang^a ; ^b ; Hao Zhang^a ; ^b ; XiaoBin Jia^a ; ^b ; FenXia Zhu^a ; ^b ; ^{zfxcjq@126.com}

关键词：Strictosamide (PubChem CID ; 10345799) ; Pumiloside (ChemSpider ID ; 8521772) ; Vincosamide (PubChem CID ; 10163855) ; DMSO (PubChem CID ; 679) ; NaNO2 (PubChem CID ; 23668193)

刊名：Journal of Ethnopharmacology

出版年：2017

6.Regulation of myocardial stromal cell-derived factor 1α/CXCL12 by tumor necrosis factor signaling

作者：Meijing Wang ; MD ; ^{meiwang@iupui.edu} ; Lina Wang ; MS ; Chunyan Huang ; MD ; I-Wen Wang ; MD ; PhD ; Mark W. Turrentine ; MD

关键词：CXCL12 ; TNF receptor ; Myocardial ischemia ; TNF signaling ; Myocardial SDF-1

刊名：Journal of Surgical Research

出版年：2017

7.In vitro antioxidative and anti-inflammatory effects of the compound K-rich fraction BIOGF1K, prepared from Panax ginseng

作者：Muhammad Jahangir Hossen¹ ; ² ; ^☆ ; Yong Deog Hong³ ; ^☆ ; Kwang-Soo Baek¹ ; Sulgi Yoo¹ ; Yo Han Hong¹ ; Ji Hye Kim¹ ; Jeong-Oog Lee⁴ ; Donghyun Kim³ ; Junseong Park³ ; ^{superbody@amorepacific.com} ; Jae Youl Cho¹ ; ^{jaecho@skku.edu}

关键词：anti-inflammatory activity ; antioxidative activity ; BIOGF1K ; compound K ; Panax ginseng

刊名：Journal of Ginseng Research

出版年：2017

8.Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model

作者：Tomoya Takeda^a ; Masanobu Tsubaki^a ; Kotaro Sakamoto^a ; Eri Ichimura^a ; Aya Enomoto^a ; Yuri Suzuki^a ; Tatsuki Itoh^b ; Motohiro Imano^c ; Genzoh Tanabe^d ; Osamu Muraoka^d ; Hideaki Matsuda^e ; Takao Satou^f ; Shozo Nishida^a ; ^{nishida@phar.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：NIK ; nuclear factor kappa B-inducing kinase ; NF-κB ; nuclear factor kappa B ; IκB ; inhibitor of kappa B ; IKK ; inhibitor of kappa B kinase ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; mTOR ; mammalian target of rapamycin ; MMP ; matrix metalloproteinase ; VLA ; very late antigen ; ECM ; extracellular matrix ; Bax ; Bcl-associated X ; Bcl-xL ; B cell leukemia-xL ; PUMA ; p53 upregulated modulator of apoptosis ; PARP-1 ; Poly (ADP ribose) polymerase-1 ; B16BL6 ; B16 melanoma BL6

刊名：Toxicology and Applied Pharmacology

出版年：2016

9.Identification of NF-κB inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico

作者：Pan Li^a ; ¹ ; Bin Lv^a ; ¹ ; Xiaoqing Jiang^a ; Ting Wang^a ; Xianghui Ma^a ; Nianwei Chang^b ; Xiaoying Wang^a ; ^b ; ^{wxy@tjutcm.edu.cn} ; Xiumei Gao^a

关键词：BMC ; Benzoyl-mesaconine ; CAD ; Coronary artery disease ; CHD ; Coronary heart disease ; DEX ; Dexamethasone ; DMEM ; Dulbecco's modified Eagle&rsquo ; s Medium ; ELISA ; Enzyme-linked immunosorbent assay ; ESI ; Electrospray ionization ; FBS ; Fetal bovine serum ; FUZ ; Fuziline ; HEK293 ; Human embryonic kidney 293 ; HTS ; High throughput screening ; IκB ; Inhibitor of NF-κB ; IKK ; Inhibitor of nuclear factor kappa-B kinase ; IL ; Interleukin ; LDH ; Lactate dehydrogenase ; LPS ; lipopolysaccharide ; MC ; Mesaconine ; MTT ; Met

刊名：Journal of Ethnopharmacology

出版年：2016

10.IκB kinase β inhibitor, IMD-0354, prevents allergic asthma in a mouse model through inhibition of CD4⁺ effector T cell responses in the lung-draining mediastinal lymph nodes

作者：Tomasz Maślanka^a ; ^{tomasz.maslanka@uwm.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Iwona Otrocka-Domagała^b ; Monika Zuśka-Prot^a ; Mateusz Mikiewicz^b ; Jagoda Przybysz^a ; Agnieszka Jasiecka^a ; Jerzy J. Jaroszewski^a

关键词：Asthma ; NF-κB ; CD4+ T cells ; Treg cells ; MLNs ; Lungs

刊名：European Journal of Pharmacology

出版年：2016

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