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在“Elsevier电子期刊”中，命中：315条，耗时：0.0529733 秒

在所有数据库中总计命中：429条

1.Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

作者：D. Lana^a ; J. Di Russo^b ; T. Mello^c ; G.L. Wenk^d ; M.G. Giovannini^a ; ^{mariagrazia.giovannini@unifi.it}

关键词：ACQ ; acquisition ; ACh ; acetylcholine ; DMSO ; dimethyl sulfoxide ; IA ; inhibitory avoidance ; i.c.v. ; intracerebroventricular ; i.p. ; intraperitoneal ; mTOR ; mammalian Target of Rapamycin ; mAChR ; muscarinic acetylcholine receptors ; mTORC12 ; mammalian Target of Rapamycin Complex 12 ; MEC ; mecamylamine ; nAChR ; nicotinic acetylcholine receptors ; p70S6K ; p70S6Kinase ; P-mTOR ; phospho-mTOR ; P-p70S6K ; phospho-p70S6K ; RAPA ; rapamycin ; SCOP ; scopolamine ; SEM ; standard error of the mean

刊名：Neurobiology of Learning and Memory

出版年：2017

2.Promoter engineering of the Saccharomyces cerevisiae RIM15 gene for improvement of alcoholic fermentation rates under stress conditions

作者：Daisuke Watanabe¹ ; Akie Kaneko² ; Yukiko Sugimoto¹ ; Shinsuke Ohnuki² ; Hiroshi Takagi¹ ; Yoshikazu Ohya² ; ^{ohya@k.u-tokyo.ac.jp}

关键词：Saccharomyces cerevisiae ; Alcoholic fermentation ; Stress response ; Greatwall protein kinase ; RIM15 ; Glucose repression ; Glucose derepression ; Gluconeogenesis ; PCK1 ; Promoter engineering

刊名：Journal of Bioscience and Bioengineering

出版年：2017

3.Arginine kinase in Toxocara canis: Exon-intron organization, functional analysis of site-directed mutants and evaluation of putative enzyme inhibitors

作者：Susiji Wickramasinghe¹ ; ^{susijij@pdn.ac.lk" class="auth_mail" title="E-mail the corresponding author} ; ^{susijijp@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Lalani Yatawara² ; Mitsuru Nagataki³ ; Takeshi Agatsuma³

关键词：Toxocara canis ; Arginine kinase ; Gene structure ; Site directed mutagenesis ; Inhibition kinetics

刊名：Asian Pacific Journal of Tropical Medicine

出版年：2016

4.Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts

作者：Katsumasa Higashi^a ; Etsuko Matsuzaki^a ; ^b ; ^{matsuzaki@college.fdcnet.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoko Hashimoto^a ; Fumi Takahashi-Yanaga^c ; Aiko Takano^a ; Hisashi Anan^b ; Masato Hirata^d ; ^{hirata1@dent.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Fusanori Nishimura^a

关键词：ALP ; alkaline phosphatase ; BMP ; bone morphogenetic protein ; ERK ; extracellular signal regulated protein kinase ; GSK-3β ; glycogen synthase kinase 3β ; I-Smad ; inhibitory Smad ; PI3K ; phosphatidylinositol 3-kinase ; ROCK ; Rho kinase ; ROI ; region of interest ; Runx2 ; Runt-related transcription factor 2 ; S1P ; sphingosine-1-phosphate

刊名：Bone

出版年：2016

5.Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors

作者：Yunkyung Jeong ; Jooyeon Lee ; Jae-Sang Ryu ; ^{ryuj@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Aurora kinase ; Click chemistry ; Hinge-binder ; 12 ; 3-Triazole ; Anticancer

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Thymoquinone strongly inhibits fMLF-induced neutrophil functions and exhibits anti-inflammatory properties in vivo

作者：Kaouthar Boudiaf^a ; ^b ; ^c ; ^d ; Margarita Hurtado-Nedelec^a ; ^b ; Sahra Amel Belambri^a ; ^b ; Jean-Claude Marie^a ; ^b ; Yacine Derradji^e ; Mustapha Benboubetra^d ; Jamel El-Benna^a ; ^b ; Pham My-Chan Dang^a ; ^b ; ^{my-chan.dang@inserm.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：AIR ; auto-inhibitory region ; DFP ; Diisopropyl fluorophosphate ; ECL ; enhanced chemiluminescence ; ERK ; extracellular signal-regulated kinase ; fMLF ; N-formyl-methionyl-leucyl-phenylalanine ; HBSS ; Hank&rsquo ; s balanced salt solution ; IBD ; inflammatory bowel disease ; MAPK ; mitogen-activated protein kinase ; MPO ; myeloperoxidase ; NOX ; neutrophil oxidase ; PKC ; Protein Kinase C ; PMA ; phorbol myristate acetate ; PMN ; polymorphonuclear neutrophil ; RA ; rheumatoid arthritis ; ROS ; reactive oxygen species ; SH3

刊名：Biochemical Pharmacology

出版年：2016

7.Reflections on: “A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function”

作者：Eric J. Nestler ^{eric.nestler@mssm.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：G alpha subunits ; Adenylyl cyclase ; Protein kinase A ; CREB ; Opiates ; Stimulants ; Drugs of abuse ; Addiction

刊名：Brain Research

出版年：2016

8.Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila

作者：Patrick Verrando^a ; ^{patrick.verrando@inra.fr" class="auth_mail" title="E-mail the corresponding author} ; ^{p.vro.autun@bbox.fr" class="auth_mail" title="E-mail the corresponding author} ; Maria Capovilla^b ; Roger Rahmani^a

关键词：ncRNA ; non-coding RNA ; miRNA ; microRNA ; mRNA ; messenger RNA ; 3&prime ; UTR ; three prime untranslated region of RNA ; TNC ; trans-nonachlor ; NHM ; normal human melanocytes ; VM ; vasculogenic mimicry ; PAS ; periodic acid Schiff ; DAPI ; 4' ; 6-diamidino-2-phenylindole ; RT-qPCR ; reverse-transcription ; quantitative real-time polymerase chain reaction

刊名：Toxicology

出版年：2016

9.Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors

作者：Taisuke Katoh^a ; ^{taisuke.katoh@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Takafumi Takai^a ; Takafumi Yukawa^a ; Tetsuya Tsukamoto^a ; Etsurou Watanabe^a ; Hideyuki Mototani^a ; Takeo Arita^a ; Hiroki Hayashi^a ; Hideyuki Nakagawa^a ; Michael G. Klein^b ; Hua Zou^b ; Bi-Ching Sang^b ; Gyorgy Snell^b ; Yoshihisa Nakada^a

关键词：PKCθ inhibitors ; 1 ; 7-Disubstituted-2 ; 2-dimethyl-2 ; 3-dihydroquinazolin-4(1H)-ones ; Inhibition of IL-2 production

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells

作者：Dandan Liu^a ; ^b ; Jordan T. Perkins^a ; ^b ; Bernhard Hennig^a ; ^b ; ^{bhennig@uky.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ac-H3 ; acetylated H3 ; ChIP ; chromatin immunoprecipitation ; CRP ; C-reactive protein ; CVD ; cardiovascular diseases ; DAPI ; 4 ; 6-diamidino-2-phenylindole ; EGCG ; epigallocatechin-3-gallate ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HAT ; histone acetyltransferase ; HDAC ; histone deacetylase ; ICAM-1 ; intercellular adhesion molecule-1 ; IKK ; I kappa B kinase ; IL ; interleukin ; NF-κB ; nuclear factor-kappa B ; PCBs ; polychlorinated biphenyls ; qRT-PCR ; quantitative real-time polymerase chain reaction ; T

刊名：Journal of Nutritional Biochemistry

出版年：2016

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