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在“Elsevier电子期刊”中，命中：900条，耗时：0.172919 秒

在所有数据库中总计命中：1,225条

1.Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells

作者：Marcus Otter ; Stefan Oswald ; Werner Siegmund ; Markus Keiser ; ^{markus.keiser@uni-greifswald.de}

关键词：Pharmaceutical excipients ; Solubilizing agents ; Drug transporter ; Uptake transport ; Organic cation transporter (OCT) ; Peptide transporter (PEPT) ; Polyethylene glycol (PEG) ; Hydroxypropyl-β-cyclodextrin ; Solutol HS 15 (macrogol 15 hydroxystearate ; polyoxyl 15 hydroxystearate) ; Cremophor ; Tween (polysorbate) ; Kolliphor (poloxamer) ; MDCK cells ; In vitro ; Cell model ; Competition assay ; Inhibition assay

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2017

2.Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies

作者：Elise Grignard^a ; Robert Taylor^b ; Mark McAllister^c ; Karl Box^b ; Nikoletta Fotaki^a ; ^{n.fotaki@bath.ac.uk}

关键词：Animal ; Gastrointestinal physiology ; Biorelevant media ; In vitro ; Dissolution testing

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

3.Mitigating Cocrystal Physical Stability Liabilities in Preclinical Formulations

作者：Sunny Bhardwaj¹ ; ^{sunny.bhardwaj2@merck.com} ; Maya Lipert² ; Annette Bak¹

关键词：cocrystals ; physical stability ; solubility ; formulation ; oral drug delivery

刊名：Journal of Pharmaceutical Sciences

出版年：2017

4.A novel intravenous vehicle for preclinical cardiovascular screening of small molecule drug candidates in rat

作者：Patricia N. Banfor ; ^{Patricia.banfor@abbvie.com" class="auth_mail" title="E-mail the corresponding author} ; Gary A. Gintant ; John M. Lipari ; Philip D. Zocharski

关键词：CV ; cardiovascular ; D5W ; 5% dextrose in water ; dP/dt ; cardiac contractility ; DMA ; N ; N-dimethylacetamide ; PG ; propylene glycol ; PEG-400 ; polyethylene glycol 400 ; DPP ; 20% N ; N-dimethylacetamide/40% propylene glycol/40% polyethylene glycol ; HR ; heart rate ; i.v. ; intravenous ; MAP ; mean arterial pressure ; NCEs ; new chemical entities

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

5.Glycerol carbonate in Ferrier reaction: Access to new enantiopure building blocks to develop glycoglycerolipid analogues

作者：Pollyanna Leite Ferreira da Costa^a ; ^b ; Valentina Nascimento Melo^a ; ^d ; Bruna Martins Guimarã ; es^a ; Marie Schuler^b ; Vanessa Pimenta^c ; Patrick Rollin^b ; Arnaud Tatibouë ; t^b ; ^{arnaud.tatibouet@univ-orleans.fr} ; Ronaldo Nascimento de Oliveira^a ; ^{ronaldo.noliveira@ufrpe.br}

关键词：Tri-O-acetyl-D-glucal ; Glycerol carbonate ; 12 ; 3-Triazole ; Click chemistry

刊名：Carbohydrate Research

出版年：2016

6.Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis

作者：Xiaoyun Lu^a ; ^b ; ^e ; ^{luxy2016@jnu.edu.cn} ; Jian Tang^b ; ^c ; ^e ; Zhiyong Liu^b ; ^c ; Minke Li^b ; Tianyu Zhang^b ; Xiantao Zhang^d ; Ke Ding^a ; ^b

关键词：Anti-tubercular agent ; Imidazo[21-b]thiazole ; Pyrazolo[51-b]thiazole ; Scaffold hopping

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Multiple biological activities and molecular docking studies of newly synthesized 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcone hybrids

作者：Rajendran Sribalan^a ; Govindharasu Banuppriya^a ; Maruthan Kirubavathi^a ; A. Jayachitra^b ; Vediappen Padmini^a ; ^{padimini_tamilenthi@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Pyrazole carboxamide ; Chalcone ; Antibacterial ; Anti-inflammatory ; Antioxidant

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry

作者：Jé ; ré ; my Soulié ; ^a ; ^{jeremy.soulie@ensiacet.fr" class="auth_mail" title="E-mail the corresponding author} ; Pierre Gras^a ; Olivier Marsan^a ; Danielle Laurencin^b ; Christian Rey^a ; Christè ; le Combes^a

关键词：(Pyro) phosphate glasses ; Soft chemistry ; Monolith

刊名：Acta Biomaterialia

出版年：2016

9.Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media

作者：Vikas Kumar^a ; ^b ; Sonali S. Bharate^a ; ^{sonalibharate@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ram A. Vishwakarma^b ; ^c ; ^{ram@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：log D ; distribution coefficient ; log P ; partition coefficient ; NCEs ; new chemical entities ; PBS ; phosphate buffer saline ; SGF ; Simulated gastric fluid ; SIF ; Simulated intestinal fluid ; RP-HPLC ; reverse-phase high-performance liquid chromatography ; tR ; retention time ; UV ; ultraviolet ; HMBC ; Heteronuclear Multiple Bond Correlation ; GI50 ; Concentration for 50% growth inhibition

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

10.Synthetic approaches to the 2014 new drugs

作者：Andrew C. Flick^a ; ^&dagger ; ; ^{andrew.flick@pfizer.com" class="auth_mail" title="E-mail the corresponding author} ; Hong X. Ding^b ; ^&Dagger ; ; ^{Sheryl.ding@pharmacodia.com" class="auth_mail" title="E-mail the corresponding author} ; Carolyn A. Leverett^a ; ^§ ; ; ^{carolyn.a.leverett@pfizer.com" class="auth_mail" title="E-mail the corresponding author} ; Robert E. Kyne Jr.^c ; ^¶ ; ; ^{rkyne@celgene.com" class="auth_mail" title="E-mail the corresponding author} ; Kevin K.-C. Liu^d ; ^‖ ; ^{kevin.liu@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Sarah J. Fink^e ; ^&dagger ; &dagger ; ; ^{sarah.fink@bioduro.com" class="auth_mail" title="E-mail the corresponding author} ; Christopher J. O&rsquo ; Donnell^a ; ^{christopher.j.odonnell@pfizer.com" class="auth_mail" title="E-mail the corresponding author}

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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