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Elsevier电子期刊(139)

在“Elsevier电子期刊”中，命中：139条，耗时：0.0499738 秒

在所有数据库中总计命中：185条

1.Design, synthesis and biological evaluation of 4′-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease

作者：Ganyuan Xiao^a ; Yan Li^a ; Xiaoming Qiang^a ; Rui Xu^a ; Yunxiaozhu Zheng^a ; Zhongcheng Cao^a ; Li Luo^a ; Xia Yang^a ; Zhipei Sang^b ; Fu Su^a ; ^{sufu@scu.edu.cn} ; Yong Deng^a ; ^{dengyong@scu.edu.cn}

关键词：Alzheimer&rsquo ; s disease ; Chalcone carbamate derivatives ; Multifunctional agents ; Acetylcholinesterase inhibitors ; Aβ aggregation inhibitors ; Monoamine oxidase B inhibitors

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors

作者：Zahra Najafi^a ; Mohammad Mahdavi^b ; Mina Saeedi^c ; ^d ; Elahe Karimpour-Razkenari^d ; Raymond Asatouri^e ; Fahimeh Vafadarnejad^a ; Farshad Homayouni Moghadam^f ; Mahnaz Khanavi^g ; Mohammad Sharifzadeh^h ; ^{msharifzadeh@tums.ac.ir} ; Tahmineh Akbarzadeh^a ; ^d ; ^{akbarzad@tums.ac.ir}

关键词：Alzheimer's disease ; Cholinesterase ; Docking study ; Dual binding ; Morris water maze ; Tacrine-12 ; 3-triazole

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin

作者：Jin Wang ; Zhi-Min Wang ; Xue-Mei Li ; Fan Li ; Jia-Jia Wu ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bing Wang ; ^{xbwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AchE ; Acetylcholinesterase ; BuChE ; Butyrylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-Amyloid ; CAS ; Catalytic anionic site ; PAS ; Peripheral anionic site ; BBB ; Blood&ndash ; brain barrier ; AβOs ; Soluble Aβ oligomers ; CNS ; Central nervous system ; NFTS ; Neurofibrillary tangles ; ChEs ; Cholinesterases ; ChEIs ; Cholinesterase inhibitors ; CDI ; 1 ; 1&prime ; -Carbonyldiimidazole ; ORAC ; Oxygen radical absorbance capacity ; PAMPA ; Parallel artificial membrane permeation assay

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study

作者：Martin Mzik^a ; Jan Korabecny^b ; Eugenie Nepovimova^b ; ^c ; Viktor Voří ; &scaron ; ek^a ; Vladimir Palička^a ; Kamil Kuca^c ; ^d ; Jana Zdarova Karasova^b ; ^c ; ^{zdarova.jana@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ACN ; acetonitrile ; AD ; Alzheimer disease ; AUCtotal ; area under curve/bioavailability ; CAS ; catalytic anionic site ; Cmax ; maximal plasma concentration ; CL ; clearance ; FDA ; US Food and drug administration ; hAChE/AChE ; human acetylcholinesterase/acetylcholinesterase ; HPLC&ndash ; MS/MS ; high performance liquid chromatography with tandem mass spectrometry ; LLE ; liquid&ndash ; liquid extraction ; LLOQ ; limit of quantitation ; THA ; tacrine ; PAS ; peripheral anionic site ; PPT ; protein precipitation ; QC ; quali

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2016

5.Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

作者：Wanli Pan^a ; Ke Hu^b ; Ping Bai^c ; Lintao Yu^a ; Qinge Ma^a ; Tao Li^a ; Xu Zhang^a ; Changzhong Chen^a ; Kelin Peng^a ; Wenmin Liu^a ; ^{liuwm1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhipei Sang^a ; ^{sangzhipei@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; Aβ ; β-amyloid peptide ; BBB ; blood&ndash ; brain barrier ; ACh ; acetylcholine ; MTDL ; multitarget-directed ligand ; EeAChE ; electric eel AChE ; CAS ; catalytic anionic site ; PAS ; peripheral anionic site ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT ; thioflavin T ; PAMPA-BBB ; parallel artificial membrane permeation assay of the blood&minus ; brain barrier

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Fluorescence properties and sequestration of peripheral anionic site specific ligands in bile acid hosts: Effect on acetylcholinesterase inhibition activity

作者：Mullah Muhaiminul Islam^a ; Kripamoy Aguan^b ; Sivaprasad Mitra^a ; ^{smitra@nehu.ac.in" class="auth_mail" title="E-mail the corresponding author} ; ^{smitranehu@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Fluorescence solvatochromism ; AChE inhibitor ; Bile acid ; Time-resolved fluorescence ; Association constant ; Enzyme kinetics

刊名：Journal of Photochemistry and Photobiology B: Biology

出版年：2016

7.Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer’s disease

作者：Yuxing Li^a ; ^&dagger ; ; Xiaoming Qiang^a ; ^&dagger ; ; Yan Li^a ; Xia Yang^a ; Li Luo^a ; Ganyuan Xiao^a ; Zhongcheng Cao^a ; Zhenghuai Tan^b ; ^{tanzhh616@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yong Deng^a ; ^{dengyong@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; HuAChE ; human AChE ; EeAChE ; Electrophorus electricus AChE ; Aβ ; β-amyloid peptide ; CAS ; catalytic active site ; PAS ; peripheral anionic site ; EDCI ; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride ; PBS ; phosphate-buffered saline ; DTNB ; 5 ; 5&prime ; -dithiobis-2-nitrobenzoic acid ; PDB ; Protein Data Bank ; TcAChE ; Torpedo californica AChE ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Toluidine blue O is a potent inhibitor of human cholinesterases

作者：Kevser Biberoglu ; Melike Yuksel Tek ; Seyhan Turk Ghasemi ; Ozden Tacal ; ^{tacal@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author}

关键词：Cholinesterases ; Phenothiazines ; Site-directed mutagenesis ; Cholinesterase inhibition ; Toluidine blue O

刊名：Archives of Biochemistry and Biophysics

出版年：2016

9.2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling

作者：Giovanna L. Delogu^a ; Maria J. Matos^b ; Maura Fanti^c ; Benedetta Era^a ; Rosaria Medda^a ; Enrico Pieroni^d ; Antonella Fais^a ; ^{fais@unica.it" class="auth_mail" title="E-mail the corresponding author} ; Amit Kumar^d ; ^e ; ^{amit369@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Francesca Pintus^a

关键词：Alzheimer&rsquo ; s disease ; Acetylcholinesterase ; Butyrylcholinesterase ; Benzofurans ; Cholinesterase inhibitors ; Molecular dynamics ; Docking

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities

作者：Wen Luo^a ; ^&dagger ; ; ^{luowen83@henu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Ying Chen^a ; ^&dagger ; ; Ting Wang^a ; Chen Hong^a ; Li-Ping Chang^a ; Cong-Cong Chang^a ; Ya-Cheng Yang^a ; Song-Qiang Xie^b ; Chao-Jie Wang^a ; ^{wcjsxq@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Flavonoid derivatives ; Cholinesterase ; Anti-Alzheimer agent ; Molecular modeling ; Cytotoxicity

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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