作者：Wennan Zhao^&dagger ; ; Yuling Qiu^&dagger ; ; Dexin Kong ; ^{kongdexin@tmu.edu.cn}

关键词：Phosphatidylinositol 3-kinase ; PI3K inhibitor ; Drug candidate ; Cancer therapy ; PI3K/mTOR selectivity ; Anticancer

刊名：Acta Pharmaceutica Sinica B

出版年：2017

作者：Mary Nakazawa ; Natasha Kyprianou ; ^{nkypr2@uky.edu}

关键词：ADT ; Androgen deprivation therapy ; AR ; Androgen receptor ; CRPC ; Castration resistant prostate cancer ; DHT ; Dihydrotestosterone ; EGF ; Epidermal growth factor ; EMT ; Epithelial mesenchymal transition ; ERβ ; Estrogen receptor β ; FGF ; Fibroblast growth factor ; IGF ; Insulin-like growth factor ; MET ; Mesenchymal epithelial transition ; PDGF ; Platelet derived growth factor ; PI3 K ; Phosphatidylinositol 3-OH kinase ; PTEN ; Phosphatase tensin homolog ; RTK ; Receptor tyrosine kinase ; SHH ; Sonic Hedgehog ; TGFβ ; T

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

作者：Ming Sang ; Chengjun Li ; Wei Wu ; Bin Li ; ^{libin@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; ^{libinlb@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：IIS ; Insulin and insulin-like growth factor signaling ; IGF ; Insulin-like growth factor ; IR ; Insulin receptor ; IGFR ; Insulin-like growth factor receptor ; IRR ; Insulin receptor-related receptor ; RNAi ; RNA interference ; ORF ; Open reading frame ; RTK ; Receptor tyrosine kinase ; ERK ; Extracellular-signal-regulated kinase ; PI3K ; Phosphatidylinositol-3-OH kinase ; Vg ; Vitellogenin ; FOXO ; Fork head transcription factor ; qRT-PCR ; Quantitative real-time PCR ; MNCs ; Median neurosecretory cells ; PDK1/2 ; Protein

刊名：Gene

出版年：2016

作者：Juan Ma ; Jing Li ; Ke Si Wang ; Chunliu Mi ; Lian Xun Piao ; Guang Hua Xu ; Xuezheng Li ; Jung Joon Lee ; Xuejun Jin ; ^{xjjin@ybu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HIF-1 ; hypoxia-inducible factor-1 ; VEGF ; vascular endothelial growth factor ; Topo-I ; topoisomerase-I ; EPO ; extracellular signal-regulated kinase-1/2 ; mTOR ; mammalian target of rapamycin ; eIF4E ; eukaryotic initiation factor 4E ; 4E-BP1 ; eIF4E binding protein-1 ; PI3K ; phosphatidylinositol 3-kinase ; HRE ; hypoxia response element ; ROS ; Reactive oxygen species ; POH ; perillyl alcohol

刊名：International Immunopharmacology

出版年：2016

作者：Eyler N. Ngoh¹ ; Shelley B. Weisser¹ ; Young Lo¹ ; Lisa K. Kozicky¹ ; Roger Jen¹ ; Hayley K. Brugger¹ ; Susan C. Menzies¹ ; Keith W. McLarren¹ ; Dominika Nackiewicz² ; Nico van Rooijen³ ; Kevan Jacobson¹ ; Jan A. Ehses² ; Stuart E. Turvey⁴ ; Laura M. Sly¹ ; ^{laurasly@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：PI3Kp110α ; Signal Transduction ; Inflammatory ; Phosphatidylinositol

刊名：Gastroenterology

出版年：2016

作者：Barbara Grü ; nwald¹ ; Veronika Harant¹ ; Susanne Schaten¹ ; Monika Frü ; hschü ; tz¹ ; Ria Spallek¹ ; Bastian Hö ; chst¹ ; Katharina Stutzer¹ ; Sonja Berchtold¹ ; Mert Erkan² ; Olga Prokopchuk² ; Marc Martignoni² ; Irene Esposito³ ; Mathias Heikenwalder⁴ ; Aayush Gupta⁵ ; Jens Siveke⁵ ; Paul Saftig⁶ ; Percy Knolle¹ ; Dirk Wohlleber¹ ; Achim Krü ; ger¹ ; ^{achim.krueger@tum.de" class="auth_mail" title="E-mail the corresponding author}

关键词：Tissue Inhibitor of Metalloproteinases ; Tumor Progression ; Signal Transduction ; Microenvironment

刊名：Gastroenterology

出版年：2016

作者：Christian Freise ; ^{christian.freise@charite.de" class="auth_mail" title="E-mail the corresponding author} ; Kerstin Sommer ; Uwe Querfeld

关键词：[Ca]i ; intracellular calcium levels ; ES ; (+)-episesamin ; HO-1 ; haem oxygenase-1 ; MAPK ; mitogen-activated protein kinase ; MMP ; matrix-metalloproteinase ; NF-魏B ; nuclear factor-kappa B ; PDGF ; platelet-derived growth factor ; PDGFR伪 ; platelet-derived growth factor receptor alpha ; PI3K ; phosphatidylinositol-3-OH-kinase ; ROS ; reactive oxygen species ; SE ; sesamin ; TNF-伪 ; tumour necrosis factor alpha ; VSMC ; vascular smooth muscle cell ; ZnPP IX ; zinc protoporphyrin IX

刊名：Journal of Functional Foods

出版年：2015

作者：Li-Han Zhang ; Xiao-Ying Tan ; ^{txy7933@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{txy7933@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Kun Wu ; Mei-Qin Zhuo ; Yu-Feng Song ; Qing-Ling Chen

关键词：ACC ; acetyl-CoA carboxylase ; CPT I ; carnitine palmitoyl transferase-I ; DMSO ; dimethyl sulphoxide ; FAS ; Fatty acid synthase ; G6PD ; glucose-6-phosphate dehydrogenase ; IRS&ndash ; PI3K ; insulin receptor substrate (IRS)&ndash ; phosphatidylinositol-3-OH-kinase ; JAK&ndash ; STAT ; Janus kinase/signal transducer and activator of transcription ; LepR ; leptin receptor ; PBS ; phosphate buffered saline ; PPAR ; peroxisome proliferators-activated receptor ; 6PGD ; 6-phosphogluconate dehydrogenase ; rt-hLEP ; recombinant

刊名：General and Comparative Endocrinology

出版年：2015

作者：Wenxi He ; DDS ; PhD^&lowast ; ; ^{hewenxi@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhihua Wang ; DDS ; MS^&lowast ; ; Zeyuan Zhou ; DDS ; PhD^&lowast ; ; Yaqing Zhang ; DDS ; PhD^&lowast ; ; Qinglin Zhu ; DDS ; PhD^&lowast ; ; Kewen Wei ; DDS ; PhD^&lowast ; ; Yuan Lin ; DDS ; PhD^&lowast ; ; Paul R. Cooper ; PhD^&dagger ; ; Anthony J. Smith ; PhD^&dagger ; ; Qing Yu ; DDS ; PhD^&lowast ; ; ^{hefmmu@aliyun.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Dental pulp stem cells ; LPS ; NF-kappaB ; PI3K/AKT ; TLR4 ; Wnt5a

刊名：Journal of Endodontics

出版年：2014

作者：Varisa Pongrakhananon ; Todd A. Stueckle ; Hua-Yu Leo Wang ; George A. O鈥橠oherty ; Cerasela Zoica Dinu ; Pithi Chanvorachote ; Yon Rojanasakul

关键词：Bcl-2 ; B-cell lymphoma 2 ; Casp-3 ; caspase-3 ; CHX ; cycloheximide ; CG ; cardiac glycoside ; DMSO ; dimethyl sulfoxide ; D6-MA ; 伪-l-rhamnose monosaccharide derivative ; ECM ; extracellular matrix ; ERK ; extracellular signal-regulated protein kinase ; FAK ; focal adhesion kinase ; GSK-3尾 ; glycogen synthase kinase-3尾 ; JNK ; c-Jun amino-terminal kinase ; MOA ; mode of action ; NSCLC ; non-small cell lung cancer ; PARP ; poly(ADP-ribose) polymerase ; PI ; propidium iodide ; PI3K ; phosphatidylinositol-3 kinase ; TDZD ; th

刊名：Biochemical Pharmacology

出版年：1 March, 2014