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在“Elsevier电子期刊”中，命中：16条，耗时：0.042978 秒

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1.Physiologically based pharmacokinetic modeling of ¹⁸F-SiFAlin-Asp₃-PEG₁-TATE in AR42J tumor bearing mice

作者：Christian Maaß ; ^a ; ^{cmaass@mit.edu" class="auth_mail" title="E-mail the corresponding author} ; Jose Ricardo Avelar Rivas^a ; Ali Asgar Attarwala^a ; Deni Hardiansyah^a ; Sabrina Niedermoser^b ; Shanna Litau^b ; ^c ; Carmen Wä ; ngler^c ; Bjö ; rn Wä ; ngler^b ; Gerhard Glatting^a

关键词：Physiologically based pharmacokinetic (PBPK) modeling ; Peptide receptor radionuclide therapy (PRRT) ; Neuroendocrine tumor (NET) ; Mice

刊名：Nuclear Medicine and Biology

出版年：2016

2.In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

作者：Giuliana Pomponio^a ; ^e ; ¹ ; Camille C. Savary^b ; ¹ ; Cé ; line Parmentier^c ; ¹ ; Frederic Bois^d ; ¹ ; André ; Guillouzo^b ; Luca Romanelli^e ; Lysiane Richert^c ; ^f ; Emma Di Consiglio^a ; ^{emma.diconsiglio@iss.it" class="auth_mail" title="E-mail the corresponding author} ; Emanuela Testai^a

关键词：AMI ; amiodarone ; MDEA ; mono-N-desethylamiodarone ; DDEA ; di-N-desethylamiodarone ; PHH ; primary human hepatocytes ; CYP ; cytochrome P450 ; DMSO ; dimetylsulfoxide ; MeOH ; methanol ; HMM ; Hepatocyte Maintenance Medium ; FCS ; fetal calf serum ; SW ; sandwich ; d0 ; day 0 ; d13 ; day 13 ; TP ; time point ; LOD ; limit of detection ; ADR ; adverse drug reactions ; PBPK ; Physiologically Based Pharmacokinetic models ; PBBK ; physiologically based biokinetic models

刊名：Toxicology in Vitro

出版年：2015

3.Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo

作者：Erryana Martati^a ; ^b ; ¹ ; ^{erryana_m@yahoo.com" class="auth_mail} ; ^{erryana_m@ub.ac.id" class="auth_mail} ; Rungnapa Boonpawa^a ; Johannes H.J. van den Berg^a ; Alicia Paini^a ; Albertus Spenkelink^a ; Ans Punt^a ; Jacques Vervoort^c ; Peter J. van Bladeren^a ; ^d ; Ivonne M.C.M. Rietjens^a

关键词：BMD ; benchmark dose ; BMDL10 ; the lower confidence limit of the benchmark dose causing 10% extra tumor incidence ; EDI ; estimated daily intake ; GSH ; glutathione reduced ; 7HC ; 7-hydroxycoumarin ; 7HCS ; 7-hydroxycoumarin sulfate ; HPLC ; high performance liquid chromatography ; 1&prime ; HSG ; 1&prime ; -hydroxysafrole glucuronide ; 1&prime ; HOS ; 1&prime ; -oxosafrole ; 1&prime ; HSS ; 1&prime ; -sulfooxysafrole ; MOE ; margin of exposure ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl) 2 ; 5-diphenyl tetrazolium bromide ; PAPS ; 3&prime

刊名：Food and Chemical Toxicology

出版年：April, 2014

4.A biokinetic model for zinc for use in radiation protection

作者：R.W. Leggett ; ^rwl@ornl.gov

关键词：Zinc ; Biokinetics ; Model ; Human body ; Radionuclides

刊名：Science of the Total Environment

出版年：2012

5.Human biokinetic data and a new compartmental model of zirconium — A tracer study with enriched stable isotopes

作者：Matthias B. Greiter ; ^a ; ^{matthias.greiter@helmholtz-muenchen.de"" rel=""nofollow} ; Augusto Giussani¹ ; ^a ; ^{AGiussani@BfS.de"" rel=""nofollow} ; Vera Hö ; llriegl^a ; ^{vera.hoellriegl@helmholtz-muenchen.de"" rel=""nofollow} ; Wei Bo Li^a ; ^{wli@helmholtz-muenchen.de"" rel=""nofollow} ; Uwe Oeh^a ; ^{uwe.oeh@helmholtz-muenchen.de"" rel=""nofollow}

关键词：Stable zirconium isotope ; Human tracer study ; Biokinetic model ; Ingestion ; Fractional absorption ; Radiation protection

刊名：Science of the Total Environment

出版年：2011

6.A biokinetic model for manganese

作者：R.W. ; Leggett ; ; ^a ; ; ^rwl@ornl.gov

关键词：Manganese ; Biokinetics ; Model ; Humans ; Radionuclides

刊名：Science of the Total Environment

出版年：2011

7.A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes

作者：Alicia Paini ; Ans Punt ; Florian Viton ; Gabriele Scholz ; Thierry Delatour ; Maricel Marin-Kuan ; Benoî ; t Schilter ; Peter J. van Bladeren ; Ivonne M.C.M. Rietjens

关键词：Estragole ; 1′ ; -Hydroxyestragole ; Bioactivation ; Physiologically based biodynamic (PBBD) model ; LC-ESI-MS/MS ; Isotope dilution ; Rat primary hepatocytes ; DNA adduct formation

刊名：Toxicology and Applied Pharmacology

出版年：2010

8.Development and specification of physiologically based pharmacokinetic models for use in risk assessment

作者：Rebecca A. Clewell ; Harvey J. Clewell III

关键词：Physiologically based pharmacokinetic modeling ; PBPK ; Physiological modeling ; Pharmacokinetics ; Toxicokinetic modeling ; Biokinetic modeling ; Risk assessment

刊名：Regulatory Toxicology and Pharmacology

出版年：2008

9.Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

作者：W. Alhusainy ; A. Paini ; A. Punt ; J. Louisse ; A. Spenkelink ; J. Vervoort ; T. Delatour ; G. Scholz ; B. Schilter ; T. Adams ; P.J. van Bladeren ; I.M.C.M. Rietjens

关键词：Estragole ; Basil ; Sulfotransferase ; Matrix ; Nevadensin ; PBBK

刊名：Toxicology and Applied Pharmacology

出版年：2010

10.Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling

作者：Ivonne M.C.M. Rietjens ; Marelle G. Boersma ; Maria Zaleska ; Ans Punt

关键词：Coumarin ; Physiologically based biokinetic (PBBK) model ; Bioactivation ; o-Hydroxyphenylacetaldehyde (oHPA) ; Interspecies differences

刊名：Toxicology in Vitro

出版年：2008

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