搜索页_ platelet-derived growth factor receptor β

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1.Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

作者：Roheeth Kumar Pavana^a ; Shruti Choudhary^a ; Anja Bastian^b ; Michael A. Ihnat^c ; Ruoli Bai^d ; Ernest Hamel^d ; Aleem Gangjee^a ; ^{gangjee@duq.edu}

关键词：AA ; antiangiogenic agents ; MTA ; microtubule targeting agents ; VEGFR-2 ; vascular endothelial growth factor receptor-2 ; PDGFR-β ; platelet-derived growth factor receptor-β ; CAM ; chorioallantoic membrane ; CA ; combretastatin A-4 ; Pgp ; P-glycoprotein ; EGFR ; epidermal growth factor receptor ; TBS ; Tris-buffered saline ; HRP ; horseradish peroxidase ; PY ; phosphotyrosine

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Expression and activation of platelet-derived growth factor β receptor, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) and extracellular signal-regulated kinase (ERK) in canine mammary tumours

作者：Gennaro Altamura^a ; ^{gennaro.altamura@unina.it} ; Barbara degli Uberti^b ; ^{barbara.degliuberti@cert.izsmportici.it} ; Giorgio Galiero^b ; ^{giorgio.galiero@cert.izsmportici.it} ; Manuela Martano^a ; ^{manuela.martano@unina.it} ; Antonella Pirro^a ; ^{divas3@hotmal.it} ; Marco Russo^a ; ^{marco.russo@unina.it} ; Giuseppe Borzacchiello^a ; ^{borzacch@unina.it}

关键词：PDGFβR ; MEK ; ERK ; TKR inhibitors ; Oncology

刊名：Research in Veterinary Science

出版年：2017

3.Epithelial-mesenchymal-transition regulators in prostate cancer: Androgens and beyond

作者：Mary Nakazawa ; Natasha Kyprianou ; ^{nkypr2@uky.edu}

关键词：ADT ; Androgen deprivation therapy ; AR ; Androgen receptor ; CRPC ; Castration resistant prostate cancer ; DHT ; Dihydrotestosterone ; EGF ; Epidermal growth factor ; EMT ; Epithelial mesenchymal transition ; ERβ ; Estrogen receptor β ; FGF ; Fibroblast growth factor ; IGF ; Insulin-like growth factor ; MET ; Mesenchymal epithelial transition ; PDGF ; Platelet derived growth factor ; PI3 K ; Phosphatidylinositol 3-OH kinase ; PTEN ; Phosphatase tensin homolog ; RTK ; Receptor tyrosine kinase ; SHH ; Sonic Hedgehog ; TGFβ ; T

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

4.The anti-ALS drug riluzole attenuates pericyte loss in the diabetic retinopathy of streptozotocin-treated mice

作者：Jeong A. Choi^a ; ¹ ; Yoo-Ri Chung^b ; ¹ ; ² ; Hyae-Ran Byun^a ; ³ ; Hwangseo Park^d ; Jae-Young Koh^a ; ^c ; ^{jkko@amc.seoul.kr} ; Young Hee Yoon^b ; ^{yhyoon@amc.seoul.kr}

关键词：AGE ; advanced glycation end products ; BRB ; blood-retinal barrier ; BSA ; bovine serum albumin ; DR ; diabetic retinopathy ; FBS ; fetal bovine serum ; FITC ; fluorescein isothiocyanate ; mLDL ; modified low-density lipoprotein ; MCP1 ; monocyte chemoattractant protein-1 ; NPDR ; nonproliferative diabetic retinopathy ; PBS ; phosphate-buffered saline ; PDGF ; platelet-derived growth factor ; PDGFR-β ; platelet-derived growth factor receptor-β ; PDR ; proliferative diabetic retinopathy ; PKC ; protein kinase C ; STZ ; stre

刊名：Toxicology and Applied Pharmacology

出版年：2017

5.Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis

作者：Ana E. Carvajal ; Marí ; a D. Vá ; zquez-Carretero ; Pablo Garcí ; a-Miranda ; Marí ; a J. Peral ; Marí ; a L. Calonge ; ^{calonge@us.es} ; Anunciació ; n A. Ilundain

关键词：α-SMA ; α-smooth muscle actin ; ApoER2 ; apolipoprotein E receptor 2 ; CASK ; calcium/calmodulin-dependent serine protein kinase ; Dab1 ; Disabled-1 ; DSS ; dextran sulphate sodium ; DNMT1 ; (DNA (Cytosine-5-)-Methyltransferase 1) ; IL-1β ; interleukin-1β ; PDGF-BB ; platelet derived growth factor β ; TGF-β1 ; transforming growth factor β1 ; TNF-α ; tumour necrosis factor α ; Sp1 ; transcription factor Sp1 ; Tbr1 ; T-box brain 1 ; VLDLR ; very low-density lipoprotein receptor

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2017

6.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

7.In Vitro and In Vivo Activity of Lucitanib in FGFR1/2 Amplified or Mutated Cancer Models

作者：Federica Guffanti^* ; ³ ; Rosaria Chilà ; ^* ; ³ ; Ezia Bello^* ; Massimo Zucchetti^&dagger ; ; Monique Zangarini^&dagger ; ; Laura Ceriani^&dagger ; ; Mariella Ferrari^&dagger ; ; Monica Lupi^&dagger ; ; Anne Jacquet-Bescond^&Dagger ; ; Mike F. Burbridge^&Dagger ; ; Marie-Jeanne Pierrat^&Dagger ; ; Giovanna Damia^* ; ^{giovanna.damia@marionegri.it}

刊名：Neoplasia

出版年：2017

8.Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion

作者：Katharina Heinzelmann^a ; Nina Noskovičová ; ^a ; Juliane Merl-Pham^b ; Gerhard Preissler^c ; Hauke Winter^c ; Michael Lindner^d ; Rudolf Hatz^c ; ^d ; Stefanie M. Hauck^b ; Jü ; rgen Behr^d ; ^e ; Oliver Eickelberg^a ; ^{oliver.eickelberg@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author}

关键词：ECM ; Extracellular matrix ; IPA ; Ingenuity pathway analysis ; IPF ; Idiopathic pulmonary fibrosis ; PDGFRα ; Platelet-derived growth factor receptor-alpha ; PDGFRβ ; Platelet-derived growth factor receptor-beta ; phF ; Primary human fibroblasts ; αSMA ; alpha-Smooth muscle actin ; TGF-β ; Transforming growth factor-beta

刊名：International Journal of Biochemistry and Cell Biology

出版年：2016

9.ERas protein is overexpressed and binds to the activated platelet-derived growth factor β receptor in bovine urothelial tumour cells associated with papillomavirus infection

作者：Valeria Russo^a ; Franco Roperto^b ; Iolanda Esposito^a ; Dora Maria Ceccarelli^a ; Nicola Zizzo^c ; Leonardo Leonardi^d ; Rosanna Capparelli^e ; Giuseppe Borzacchiello^a ; Sante Roperto^f ; ^{sante.roperto@unina.it" class="auth_mail" title="E-mail the corresponding author}

关键词：Cattle ; Urothelial tumours ; Embryonic stem cell-expressed Ras (ERas) ; Platelet-derived growth factor β receptor (PDGFβR) ; Papillomavirus E5 oncoprotein

刊名：The Veterinary Journal

出版年：2016

10.Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic valve stenosis: Evidence of systemic activation of platelet-derived TGF-β1 and correlation with cardiac dysfunction

作者：Wei Wang ; Nathalie Burg ; Spandana Vootukuri ; Barry S. Coller ; ^{collerb@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AS ; aortic valve stenosis ; SS ; shear stress ; AV ; aortic valve ; PLA ; platelet-leukocyte aggregate ; WD ; western type diet ; PSGL-1 ; P-selectin glycoprotein ligand-1 ; PGE1 ; prostaglandin E1 ; MLEC ; mink lung epithelial cells ; EF ; ejection fraction ; FS ; fractional shortening ; rhTGF-β1 ; recombinant human TGF-β1 ; TGFb-RI ; transforming growth factor-β receptor I ; ELISA ; enzyme-linked immunosorbent assay ; PAI-1 ; plasminogen activator inhibitor

刊名：Blood Cells, Molecules and Diseases

出版年：2016

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