作者：Maurice J. van Eis ; ^{maurice.van_eis@novartis.com} ; JeanPierre Evenou ; Walter Schuler ; Gerhard Zenke ; Eric Vangrevelinghe ; Juergen Wagner ; Peter von Matt

关键词：PKC alpha/beta ; Inhibitors ; T-cell activation ; B-cell activation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

作者：Nicla PorcielloAuthor Vitae ; Loretta Tuosto ; ^{loretta.tuosto@uniroma1.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae

关键词：MHC ; major histocompatibility complex ; TCR ; T-cell receptor ; APC ; antigen presenting cell ; Ig ; immunoglobulin ; IL ; interleukin ; IS ; immunological synapse ; PLCγ1 ; phospholipase Cγ1 ; LAT ; linker for activation of T cells ; Grb2 ; growth-factor receptor-bound protein ; GADS ; Grb2-related adaptor downstream of Shc ; PKCθ ; protein kinase C θ ; ERK ; extracellular signal regulated kinases ; JNK ; jun N-terminal kinases ; NF-AT ; nuclear factor of activated T cells ; NF-κB ; nuclear factor-κB ; AP-1 ; activator prot

刊名：Cytokine & Growth Factor Reviews

出版年：2016

作者：Alexandre Pinel^a ; ^{alexandre.pinel@clermont.inra.fr" class="auth_mail" title="E-mail the corresponding author} ; Jean-Paul Rigaudiè ; re^a ; ^{jean-paul.rigaudiere@clermont.inra.fr" class="auth_mail" title="E-mail the corresponding author} ; Brigitte Laillet^a ; ^{brigitte.laillet@clermont.inra.fr" class="auth_mail" title="E-mail the corresponding author} ; Corinne Pouyet^b ; ^{corinne.pouyet@clermont.inra.fr" class="auth_mail" title="E-mail the corresponding author} ; Corinne Malpuech-Brugè ; re^a ; ^{corinne.malpuech-brugere@udamail.fr" class="auth_mail" title="E-mail the corresponding author} ; Carina Prip-Buus^c ; ^{carina.prip-buus@inserm.fr" class="auth_mail" title="E-mail the corresponding author} ; B&eacute ; atrice Morio^a ; ^d ; ^{beatrice.morio@clermont.inra.fr" class="auth_mail" title="E-mail the corresponding author} ; Fr&eacute ; d&eacute ; ric Capel^a ; ^{frederic.capel@clermont.inra.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：2-NBDG ; fluorescent glucose analog ; ALA ; alpha-linolenic acid ; AMPK ; AMP-activated protein kinase ; AS160 ; AKT substrate of 160  ; kDa ; cpt1 ; carnitine palmitoyltransferase 1 ; DMEM ; Dulbecco's modified eagle medium ; DHA ; docosahexaenoic acid ; DPH ; diphenyl-hexatriene ; ECL ; enhanced chemiluminescence ; EPA ; eicosapentaenoic acid ; EtOH ; ethanol ; FAT ; fatty acid transporter ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; GLUT ; glucose transporter ; hprt ; hypoxanthine guanine phosphoribosyltransfer

刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids

出版年：2016

作者：Yuriko Sato ; Chiaki Murakami ; Atsumi Yamaki ; Satoru Mizuno ; Hiromichi Sakai ; Fumio Sakane ; ^{sakane@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：AGK ; acylglycerol kinase ; DG ; diacylglycerol ; DGK ; diacylglycerol kinase ; LPA ; lysophosphatidic acid ; MG ; monoacylglycerol ; MGK ; monoacylglycerol kinase ; PA ; phosphatidic acid ; PS ; phosphatidylserine

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2016

作者：Taisuke Katoh^a ; ^{taisuke.katoh@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Takafumi Takai^a ; Takafumi Yukawa^a ; Tetsuya Tsukamoto^a ; Etsurou Watanabe^a ; Hideyuki Mototani^a ; Takeo Arita^a ; Hiroki Hayashi^a ; Hideyuki Nakagawa^a ; Michael G. Klein^b ; Hua Zou^b ; Bi-Ching Sang^b ; Gyorgy Snell^b ; Yoshihisa Nakada^a

关键词：PKCθ inhibitors ; 1 ; 7-Disubstituted-2 ; 2-dimethyl-2 ; 3-dihydroquinazolin-4(1H)-ones ; Inhibition of IL-2 production

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

作者：Soyoung Kim ; So-Young Chun ; Yun-Suk Kwon ; Kyung-Soo Nam ; ^{namks@dongguk.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：PKC ; protein kinase C ; TPA ; 12-O-tetradecanoylphorbol-13-acetate ; EMT ; epithelial-mesenchymal transition ; DAG ; diacylglycerol ; FZD ; frizzled ; LRP5/6 ; lipoprotein receptors 5/6 ; PLC ; phospholipase C ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GSK3β ; glycogen synthase kinase-3β

刊名：Biomedicine & Pharmacotherapy

出版年：2016

作者：Wenjun Zhao^a ; Aiyun Li^b ; ^c ; Xin Feng^a ; Ting Hou^a ; Kang Liu^b ; ^c ; Baolin Liu^b ; ^c ; Ning Zhang^a ; ^{ningzh18@yeah.net" class="auth_mail" title="E-mail the corresponding author}

关键词：FFAs ; free fatty acids ; HFD ; high-fat diet ; HIF-1α ; hypoxia inducible factor-1α ; VEGF ; vascular endothelial growth factor ; Glut1 ; glucose transporter 1 ; DAG ; diacylglycerol ; PKCθ ; protein kinase Cθ ; PDE3B ; phosphodiesterase 3B ; cAMP ; cyclic AMP

刊名：Cellular Signalling

出版年：2016

作者：Joanne Trinh ; BSc^a ; Emil K Gustavsson ; MSc^a ; ^g ; Carles Vilariñ ; o-Gü ; ell ; PhD^a ; Stephanie Bortnick ; BSc^a ; Jeanne Latourelle ; PhD^b ; Marna B McKenzie ; BSc^a ; Chelsea Szu Tu ; MSc^a ; Ekaterina Nosova ; PhD^a ; Jaskaran Khinda ; BSc^a ; Austen Milnerwood ; PhD^a ; Suzanne Lesage ; PhD^d ; Alexis Brice ; MD^d ; ^e ; Meriem Tazir ; MD^f ; Jan O Aasly ; MD^g ; Laura Parkkinen ; PhD^h ; Hazal Haytural ; MSc^h ; Tatiana Foroud ; PhDⁱ ; Richard H Myers ; PhD^c ; Samia Ben Sassi ; MD^j ; Emna Hentati ; MD^j ; Fatma Nabli ; MD^j ; Emna Farhat ; MD^j ; Rim Amouri ; PhD^j ; Fay&ccedil ; al Hentati ; MD^j ; Dr Matthew J Farrer ; PhD^a ; ^{mfarrer@can.ubc.ca" class="auth_mail" title="E-mail the corresponding author}

刊名：Lancet Neurology

出版年：2016

作者：Kimberley J. Anderson ; Aaron P. Russell ; Victoria C. Foletta ; ^{victoria.foletta@deakin.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：NDRG2 ; N-myc downstream-regulated gene 2 ; MRFs ; myogenic regulatory factors ; Cdk ; cyclin-dependent kinase ; Rb ; retinoblastoma ; Myf5 ; myogenic factor 5 ; MyoD ; myogenic differentiation ; p27 ; p27 kip1 ; p21 ; p21 waf1/cip1 ; Akt ; thymoma viral proto-oncogene ; PKCθ ; protein kinase C theta ; SGK1 ; serum- and glucocorticoid-inducible kinase 1 ; Bcl-2 ; B cell leukemia/lymphoma 2 ; Bax ; Bcl-2-associated X protein ; Bcl-xL ; Bcl-2-like 1 ; Mcl-1 ; myeloid cell leukemia 1 ; PARP ; poly (ADP-ribose) polymerase family

刊名：FEBS Open Bio

出版年：2015

作者：Jonna Frasor^a ; ^{jfrasor@uic.edu" class="auth_mail" title="E-mail the corresponding author} ; Lamiaa El-Shennawy^b ; Joshua D. Stender^c ; Irida Kastrati^a

关键词：ABCG2 ; ATP-binding cassette sub-family G member 2 ; BIRC3 ; baculoviral IAP Repeat Containing 3 ; BLIMP1 ; B-lymphocyte-induced maturation protein ; E2 ; 17β estradiol ; ER ; estrogen receptor ; ERE ; estrogen response element ; EZH2 ; enhancer of zeste homolog 2 ; FoxA1 ; forkhead box A1 ; FoxO3a ; forkhead box O3 ; NCoR1 ; nuclear receptor corepressor 1 ; NFκB-RE ; NFκB response element ; NFκB ; nuclear factor κB ; PKCθ ; protein kinase C θ ; PTGES ; prostaglandin E synthase

刊名：Molecular and Cellular Endocrinology

出版年：2015