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在“Elsevier电子期刊”中，命中：72条，耗时：0.0259815 秒

在所有数据库中总计命中：113条

1.Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9

作者：Boyoung Choi^a ; Suyeon Kim^a ; Bong-Geum Jang^a ; Min-Ju Kim^a ; ^b ; ^{zolim@hallym.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer's disease ; Aβ ; beta-amyloid ; APP ; amyloid precursor protein ; APPsw ; APP Swedish mutant ; NEP ; neprilysin or neutral endopeptidase ; IDE ; insulin degrading enzyme ; MMP-9 ; matrix metalloproteinase-9 ; HEK293 ; human embryonic kidney 293 ; CTF ; carboxyl terminal fragment ; sAPP ; soluble APP ; AICD ; APP intracellular domain ; NICD ; notch intracellular domain ; PARP ; poly (ADP-rebose) polymerase ; FL-APP ; full length APP ; Res ; resveratrol ; Oxy ; oxyresveratrol ; Pice ; piceatannol

刊名：Journal of Functional Foods

出版年：2016

2.Late running is not too late against Alzheimer's pathology

作者：Arne Herring^a ; ; Yvonne Mü ; nster^a ; Judith Metzdorf^a ; Bastien Bolczek^a ; Sarah Krü ; ssel^a ; David Krieter^a ; Ilkay Yavuz^a ; Fro Karim^a ; Constanze Roggendorf^a ; Anthony Stang^a ; Yachao Wang^b ; Dirk M. Hermann^b ; Sarah Teuber-Hanselmann^a ; Kathy Keyvani^a ; ^{kathy.keyvani@uk-essen.de" class="auth_mail" title="E-mail the corresponding author}

关键词：Aβ ; beta-amyloid ; APP ; amyloid precursor protein ; BBB ; blood-brain barrier ; CTFβ ; C-terminal fragment β of APP ; sAPPα ; soluble APP α fragment

刊名：Neurobiology of Disease

出版年：2016

3.Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles

作者：Chin-Yu Lin^a ; Federico Perche^a ; Masaru Ikegami^a ; Satoshi Uchida^a ; Kazunori Kataoka^a ; ^b ; ^{kataoka@bmw.t.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Keiji Itaka^a ; ^{itaka-ort@umin.net" class="auth_mail" title="E-mail the corresponding author}

关键词：Messenger RNA ; Gene therapy ; Amyloid ; Polyplex nanomicelle ; mRNA-based therapeutics

刊名：Journal of Controlled Release

出版年：2016

4.Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2)

作者：Takafumi Takai ; ^{takafumi.takai@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Tatsuki Koike ; Minoru Nakamura ; Yuichi Kajita ; Toshiro Yamashita ; Naohiro Taya ; Tetsuya Tsukamoto ; Tomomichi Watanabe ; Koji Murakami ; Tomoko Igari ; Makoto Kamata

关键词：GSM ; γ-secretase modulator ; Aβ ; amyloid beta ; AD ; Alzheimer&rsquo ; s disease ; LLE ; ligand-lipophilicity efficiency ; NORT ; novel object recognition test ; APP ; amyloid precursor protein ; MLM ; mice liver microsomes ; CNS ; central nervous system ; WT ; wild type

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult

作者：William I. Rosenblum

关键词：Alzheimer's disease ; Clinical trial failures ; Neurotoxic soluble oligomers ; Soluble ABeta amyloid ; Correlation of soluble oligomers with cognitive decline ; Synapses ; Cognitive decline ; Autopsies ; Senile plaques ; Interrelationship of senile plaque amyloid and soluble oligomers ; Tau ; Neurofibrillary tangles

刊名：Neurobiology of Aging

出版年：May, 2014

6.Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus

关键词：A尾 ; amyloid-beta ; iNPH ; idiopathic normal pressure hydrocephalus ; LPS ; lumboperitoneal shunting ; iNPHGS ; iNPH Grading Scale ; MMSE ; Mini Mental State Examination ; FAB ; frontal assessment battery ; TMT-A ; trail making test part A ; mRS ; modified Rankin Scale ; NC ; normal control ; LP ; lumbar puncture ; sAPP ; soluble amyloid precursor protein ; sAPP伪 ; sAPP alpha ; sAPP尾 ; sAPP beta ; APP ; amyloid precursor protein ; AUC ; area under the curve ; ROC ; receiver operating characteristic ; IQR ; interquartile range

刊名：Journal of the Neurological Sciences

出版年：2015

7.The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model

作者：Patricia Spilman ; Olivier Descamps ; Olivia Gorostiza ; Clare Peters-Libeu ; Karen S. Poksay ; Alex ; er Matalis ; Jesus Campagna ; Alex ; er Patent ; Rammohan Rao ; Varghese John ; Dale E. Bredesen

关键词：AD ; Alzheimer's disease ; APP ; amyloid precursor protein ; A尾 ; amyloid beta ; sAPP伪 ; soluble amyloid precursor protein alpha ; sAPP尾 ; soluble amyloid precursor protein beta ; CHO7W ; Chinese hamster ovary cells stably transfected with human APP wildtype ; 伪7nAChR ; alpha 7 nicotinic acetylcholine receptor ; 5-HT3 ; 5-hydroxytryptophan 3 (receptor) ; GABA ; gamma-aminobutyic acid ; PONV ; post-operative nausea and vomiting ; MCI ; mild cognitive impairment ; BACE ; beta-site APP cleaving enzyme ; Jcasp ; juxtame

刊名：Brain Research

出版年：10 March, 2014

8.Carnosic acid suppresses the production of amyloid-尾 1-42 and 1-43 by inducing an 伪-secretase TACE/ADAM17 in U373MG human astrocytoma cells

作者：Hidemi Yoshida^a ; ^{hidemi_yoshida@gakushikai.jp" class="auth_mail} ; ^{hidemiyo@cc.hirosaki-u.ac.jp" class="auth_mail} ; Pengfei Meng^a ; Tomoh Matsumiya^a ; Kunikazu Tanji^b ; Ryo Hayakari^a ; Fei Xing^a ; Liang Wang^a ; Kazushi Tsuruga^c ; Hiroshi Tanaka^c ; ^d ; Junsei Mimura^e ; Kunio Kosaka^f ; Ken Itoh^e ; Ippei Takahashi^g ; Tadaatsu Imaizumi^a

关键词：A尾 ; amyloid-尾 ; AD ; Alzheimer's disease ; ADAM ; a disintegrin and metalloproteinase ; APP ; amyloid precursor protein ; BACE1 ; 尾-site APP-cleaving enzyme-1 ; BCA ; bicinchoninic acid ; BSA ; bovine serum albumin ; CA ; carnosic acid ; CHAPS ; 3-[(3-Cholamidopropyl) dimethylammonio]propanesulfonate ; CHX ; cycloheximide ; DMEM ; Dulbecco's Modified Eagle's Medium ; DMSO ; dimethyl sulfoxide ; ECE1 ; endothelin-converting enzyme-1 ; ELISA ; enzyme-linked immumosorbent assay ; FBS ; fetal bovine serum ; HRP ; horseradish

刊名：Neuroscience Research

出版年：February, 2014

9.Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

作者：Meredith A. Chabrier¹ ; David Cheng ; Nicholas A. Castello¹ ; Kim N. Green ; Frank M. LaFerla ; ^{laferla@uci.edu" class="auth_mail}

关键词：AD ; Alzheimer's disease ; A尾 ; amyloid-beta ; APP ; amyloid precursor protein

刊名：Neurobiology of Disease

出版年：April, 2014

10.Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease

作者：Xiao-Tian Huang ; Zhong-Ming Qian ; Xuan He ; Qi Gong ; Ka-Chun Wu ; Li-Rong Jiang ; Li-Na Lu ; Zhou-jing Zhu ; Hai-Yan Zhang ; Wing-Ho Yung ; Ya Ke

关键词：Huperzine A ; Alzheimer's disease ; Brain iron ; Transferrin receptor 1 ; Double transgenic APPswe/PS1dE9 mice (APP/PS mice) ; The neuronal amyloid precursor protein (APP)

刊名：Neurobiology of Aging

出版年：May, 2014

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