搜索页_+the+ligand+binding+domain+of+farnesoid+X+receptor

常用资源

电子图书

期刊论文

学位会议

外文资源

Elsevier电子期刊(31)

在“Elsevier电子期刊”中，命中：31条，耗时：0.0589709 秒

在所有数据库中总计命中：39条

1.Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor

作者：Alejandro Carazo^a ; Lucie Hyrsova^a ; Jan Dusek^a ; Hana Chodounska^b ; Alzbeta Horvatova^a ; Karel Berka^c ; Vaclav Bazgier^c ; Hongying Gan-Schreier^d ; Waleé ; Chamulitrat^d ; Eva Kudova^b ; Petr Pavek^a ; ^{petr.pavek@faf.cuni.cz}

关键词：BA ; bile acid ; CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; CYP ; cytochrome P450 ; DCA ; deoxycholic acid ; 6-ECDCA ; 6α-ethyl-chenodeoxycholic acid ; obeticholic acid ; FXR ; farnesoid X receptor ; LBD ; ligand binding domain ; LCA ; lithocholic acid ; PXR ; pregnane X receptor ; TR-FRET ; time-resolved fluorescence energy transfer ; VDR ; vitamin D receptor

刊名：Toxicology Letters

出版年：2017

2.Radioligand binding assay for accurate determination of nuclear retinoid X receptors: A case of triorganotin endocrine disrupting ligands

作者：Lucia Toporova ; Dana Macejova ; Julius Brtko ; ^{julius.brtko@savba.sk" class="auth_mail" title="E-mail the corresponding author}

关键词：ATRA ; all-trans retinoic acid ; Bmax ; maximal binding capacity (pmol/mg) ; DNA ; deoxyribonucleic acid ; DR ; direct repeat ; DTT ; 1 ; 4-dithiothreitol ; FXR ; farnesoid X receptor ; Ka ; affinity (l/mol) ; LBD ; ligand-binding domain ; LXR ; liver X receptor ; PMSF ; phenylmethylsulfonyl fluoride ; PPAR ; peroxisome proliferator activated receptor ; PXR ; pregnane X receptor ; RAR ; retinoid receptor ; RARE ; retinoid response element ; RXR ; retinoid X receptor (rexinoid receptor) ; RXRE ; retinoid X response element ; TBT-

刊名：Toxicology Letters

出版年：2016

3.Oleanolic acid-NO donor-platinum(II) trihybrid molecules: Targeting cytotoxicity on hepatoma cells with combined action mode and good safety

作者：Lei Fang^a ; ^b ; Minchang Feng^a ; Feihong Chen^a ; Xia Liu^c ; Hong Shen^c ; Jian Zhao^a ; Shaohua Gou^a ; ^{sgou@seu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：CDCA ; endogenous ligand chenodeoxycholic acid ; FXR ; farnesoid X receptor ; FXR-LBD ; the ligand binding domain of farnesoid X receptor ; Hb ; hemoglobin ; ISDN ; isosorbide dinitrate ; NO ; nitric oxide ; OA ; oleanolic acid ; OA-NO ; oleanolic acid nitric oxide donor derivatives ; PBS ; phosphate buffer solution ; UA ; ursodesoxycholic acid

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies

作者：Liping Yang^a ; David Broderick^a ; Yan Campbell^d ; ^f ; Adrian F. Gombart^d ; ^f ; Jan F. Stevens^d ; ^e ; Yuan Jiang^c ; Victor L. Hsu^f ; ; William H. Bisson^b ; ; Claudia S. Maier^a ; ^d ; ^{Claudia.maier@oregonstate.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：FXR ; farnesoid X receptor ; HDX-MS ; hydrogen deuterium exchange mass spectrometry ; MetS ; metabolic syndromes ; SHP ; small heterodimer partner ; BSEP ; bile salt export pump ; LBD ; ligand binding domain ; XN ; xanthohumol ; IX ; isoxanthohumol ; 8-PN ; 8-prenylnarigenin ; TX ; tetrahydroxanthohumol ; DBD ; DNA-binding domain ; CDCA ; chenodeoxycholic acid ; GG ; guggulsterone ; IPTG ; isopropyl-β-d-thiogalactopyranoside ; DMSO ; dimethylsulfoxide ; HSA ; human serum albumin ; PLGS ; ProteinLynx Global Server

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2016

5.The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

关键词：FLU ; flutamide ; AhR ; aryl hydrocarbon receptor ; ARNT ; aryl hydrocarbon receptor nuclear translocator ; CYP ; cytochrome P450 ; TCDD ; 237 ; 8-tetrachlorodibenzo-p-dioxin ; 3-MC ; 3-methylcholanthrene ; ABCC4 ; ATP-binding cassette sub-family C member 4 ; MRP4 ; multidrug resistance-associated protein 4 ; PAS ; Per-ARNT-Sim ; DRE ; dioxin-responsive elements ; LBD ; ligand binding domain ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; ALP ; alkaline phosphatase ; PXR ; pregnane X receptor ; CAR ; con

刊名：Biochemical Pharmacology

出版年：2016

6.Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation

作者：Ingrid Richter^a ; ^b ; ^{Ingrid.Richter@cawthron.org.nz" class="auth_mail" title="E-mail the corresponding author} ; Andrew E. Fidler^a ; ^c ; ^d

关键词：AF-1 ; transcription activation function 1 ; AR ; androgen receptor ; BsVDR/PXR伪 ; Botryllus schlosseri VDR/PXR ortholog 伪 ; BSA ; bovine serum albumin ; bp ; base pair ; CAR ; constitutive androstane receptor ; CiVDR/PXR伪 ; Ciona intestinalis VDR/PXR ortholog 伪 ; CiVDR/PXR尾 ; Ciona intestinalis VDR/PXR ortholog 尾 ; DBD ; DNA-binding domain ; dN/dS ; ratio of non-synonymous substitutions per non-synonymous site (dN) to synonymous substitutions per synonymous site (dS) ; ER ; estrogen receptor ; FXR ; farnesoid X recep

刊名：Marine Genomics

出版年：2015

7.Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor

作者：Donna D. Yu^a ; ^&dagger ; ; ^{dyu@coh.org" class="auth_mail} ; Wenwei Lin^b ; ^&dagger ; ; Barry M. Forman^a ; ^&dagger ; ; Taosheng Chen^b ; ^&dagger ; ; ^{taosheng.chen@stjude.org" class="auth_mail}

关键词：HTS ; high-throughput screen ; FXR ; farnesoid X receptor ; NRs ; nuclear receptors ; Cyp7A1 ; cytochrome 7A1 ; BAs ; bile acids ; BSEP ; bile salt export pump ; SAR ; structure&ndash ; activity relationship ; LBD ; ligand-binding domain

刊名：Bioorganic and Medicinal Chemistry

出版年：1 June 2014

8.Epigenomic regulation of bile acid metabolism: Emerging role of transcriptional cofactors

作者：Zachary Smith¹ ; Daniel Ryerson¹ ; Jongsook Kim Kemper ; ^{jongsook@uiuc.edu}

关键词：FXR ; farnesoid X Receptor ; PTM ; post-translational modification ; NR ; nuclear receptor ; DBD ; DNA binding domain ; LBD ; ligand binding domain ; GPCR ; G-protein coupled receptor ; GLP-1 ; glucagon-like peptide 1 ; ChIP ; chromatin immunoprecipitation ; Cyp7a1 ; chol

刊名：Molecular and Cellular Endocrinology

出版年：2013

9.Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

作者：Donna D. Yu^a ; ^&dagger ; ; ^dyu@coh.org ; Wenwei Lin^b ; ^&dagger ; ; Taosheng Chen^b ; ; Barry M. Forman^a

关键词：FXR ; farnesoid X receptor ; NRs ; nuclear receptors ; HTS ; high-throughput screen ; LBD ; ligand-binding domain ; TR-FRET ; time resolved fluorescence resonance energy transfer

刊名：Bioorganic and Medicinal Chemistry

出版年：2013

10.Molecular and expression analysis of the farnesoid X receptor in the urochordate Halocynthia roretzi

作者：Sejung Maeng^a ; ¹ ; Jung Hwan Lee^a ; ¹ ; Gil Jung Kim^a ; Sung Hun Kim^a ; ^b ; Hak Cheol Kwon^b ; Yun Kyung Shin^c ; Young Chang Sohn^a ; ^{ycsohn@gwnu.ac.kr}

关键词：AF-1 ; Activation function-1 ; AF-2 ; Activation function-2 ; AM580 ; 4-[(567 ; 8-Tetrahydro-558 ; 8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid ; CA ; Cholic acid ; Carbazole ; 6-Formylindolo[3 ; 2-b]carbazole ; DBD ; DNA-binding domain ; DCA ; Deoxycholic acid

刊名：Comparative Biochemistry and Physiology, Part B

出版年：2012

按检索点细分(31)

关键词(7)

文摘(20)

按出版年细分(31)

2017年(1)

2016年(4)

2015年(1)

2013年(3)

2012年(4)

2011年(2)

2010年(2)

2009年(1)

2006年(1)

2004年(1)

2003年(5)

2002年(1)

2000年(3)

2000年及以前(2)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700