搜索页_3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU)

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Elsevier电子期刊(116)

在“Elsevier电子期刊”中，命中：116条，耗时：0.0109937 秒

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1.Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O⁶-alkylguanine-DNA alkyltransferase

作者：Guohui Sun ; Na Zhang ; Lijiao Zhao ; ^{zhaolijiao@bjut.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Tengjiao Fan ; Shufen Zhang ; Rugang Zhong

关键词：CENUs ; chloroethylnitrosoureas ; ACNU ; 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea ; BCNU ; 1 ; 3-bis(2-chloroethyl)-1-nitrosourea ; CCNU ; 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea ; me-CCNU ; 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea ; ICLs ; interstrand cross-links ; O6-ClEtdGuo ; O6-(2-chloroethyl)deoxyguanosine ; N1 ; O6-EtdGuo ; N1 ; O6-ethanodeoxyguanosine ; dGuo ; deoxyguanosine ; dCyd ; deoxycytidine ; AGT ; O6-alkylguanine-DNA alkyltransferase ; Cys145 ; cysteine14

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

2.Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

作者：Lauren Rouleau^a ; ¹ ; Anil Noronha Antony^a ; ¹ ; Sara Bisetto^a ; Andrew Newberg^c ; Cataldo Doria^d ; Mark Levine^b ; Daniel A. Monti^c ; ; Jan B. Hoek^a ; ^{jan.hoek@jefferson.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AA ; ascorbic acid ; AT ; 3-amino-12 ; 4-triazole ; BCNU ; bis-chloroethyl nitrosourea ; BSA ; bovine serum albumin ; [Ca2+cyto] ; cytosolic calcium concentration ; CI ; combination index ; DRI ; dose reduction index ; EC ; effective concentration ; FCCP ; Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone ; GPX ; glutathione peroxidase ; GOX ; glucose oxidase ; HCC ; hepatocellular carcinoma ; MTT ; (3-(4 ; 5-Dimethylthiazol-2-yl)-2 ; 5-Diphenyltetrazolium Bromide) ; ROS ; reactive oxygen species ; SVCT ; sodium-dependent vitam

刊名：Free Radical Biology and Medicine

出版年：2016

3.Glutathione, glutathione disulfide, and S-glutathionylated proteins in cell cultures

作者：Daniela Giustarini^a ; ^{giustarini@unisi.it" class="auth_mail" title="E-mail the corresponding author} ; Federico Galvagni^b ; Anna Tesei^c ; Alberto Farolfi^d ; Michele Zanoni^c ; Sara Pignatta^c ; Aldo Milzani^e ; Ilaria M. Marone^f ; Isabella Dalle-Donne^e ; Romina Nassini^f ; Ranieri Rossi^a

关键词：actinSSG ; S-glutathionylated actin ; BAEC ; bovine aortic endothelial cells ; BCNU ; 1 ; 3-bis(2-chloroethyl)-1-nitrosourea ; DMEM ; Dulbecco&rsquo ; s modified eagle medium ; DTT ; dithiothreitol ; EMEM ; Eagle's minimum essential medium ; FBS ; fetal bovine serum ; GR ; glutathione disulfide reductase ; GSH ; glutathione ; GSSG ; glutathione disulfide ; HUVEC ; human umbilical vein endothelial cells ; mBrB ; monobromobimane ; NEM ; N-ethylmaleimide ; PBS ; phosphate buffered saline solution ; PSSG ; S-glutathionylated protei

刊名：Free Radical Biology and Medicine

出版年：2015

4.Kinetics of micronucleus induction and cytotoxicity caused by distinct antineoplastics and alkylating agents in vivo

作者：Pedro Morales-Ram铆rez ; Teresita Vallarino-Kelly ; Virginia Cruz-Vallejo

关键词：MN-PCE ; micronucleated polychromatic erythrocytes ; aza-C ; 5-aza-cytidine ; BCNU ; bis-chloroethyl-nitrosourea ; BUS ; busulfan ; COL ; colchicine ; CP ; cyclophosphamide ; DMN ; dimethylnitrosamine ; ENU ; ethylnitrosourea ; MMC ; mitomycin C ; MNU ; methylnitrosourea ; VNB ; vinblastine ; VNC ; vincristine

刊名：Toxicology Letters

出版年：30 January, 2014

5.PFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in Cancer

作者：Minsuh Seo ; Yong-Hwan Lee

关键词：ROS ; reactive oxygen species ; PKM ; pyruvate kinase M ; PFK ; phosphofructokinase ; PFK ; phosphofructokinase ; BCNU ; 1 ; 3-bis(2-chloroethyl)-1-nitrosourea ; WT ; wild type ; EDTA ; ethylenediaminetetraacetic acid ; DMEM ; Dulbecco's modified Eagle's medium ; FCS ; fetal calf serum

刊名：Journal of Molecular Biology

出版年：20 February, 2014

6.BCNU-induced gR2 DEFECT mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium

作者：Patrick T. Kang ; Chwen-Lih Chen ; Pei Ren ; Giacinta Guarini ; Yeong-Renn Chen ; ^{ychen1@neomed.edu" class="auth_mail} ; ^{chenyeongrenn@gmail.com" class="auth_mail}

关键词：GR ; glutathione reductase ; NQR ; NADH ubiquinone reductase ; or mitochondrial Complex I ; O2&minus ; superoxide anion radical ; ETC ; electron transport chain ; OCR ; oxygen consumption rate ; RCI ; respiratory control index ; Q1 ; ubiquinone-1 ; DMPO ; 5 ; 5-dimethyl pyrroline N-oxide ; FMN ; flavin mononucleotide ; BCNU ; 1 ; 3-bischloroethyl-l-nitrosourea ; SOD-2 or MnSOD ; manganese-containing superoxide dismutase ; PEG-SOD ; polyethylene glycol-linked superoxide dismutase ; FCCP ; carbonyl cyanide-4-(trifluoromethoxy

刊名：Biochemical Pharmacology

出版年：15 June 2014

7.Evaluation of a dithiocarbamate derivative as a model of thiol oxidative stress in H9c2 rat cardiomyocytes

作者：Jiashu Xie ; Ashley Potter ; Wei Xie¹ ; Christophina Lynch ; Teresa Seefeldt ; ^{Teresa.Seefeldt@sdstate.edu" class="auth_mail}

关键词：TRS ; thiol redox state ; 2-AAPA ; 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid ; GSH ; reduced form of glutathione ; GSSG ; oxidized form of glutathione ; or glutathione disulfide ; ROS ; reactive oxygen species ; GR ; glutathione reductase ; Trx ; thioredoxin ; TrxR ; thioredoxin reductase ; BCNU ; N ; N&prime ; -bis(2-chloroethyl)-N-nitrosourea ; BSO ; buthionine sulfoximine ; MTT ; 3-(4 ; 5)-dimethylthiazol-2 ; 5-diphenyltetrazolium bromide ; DTNB ; 5

刊名：Free Radical Biology and Medicine

出版年：May 2014

8.Luteolin inhibits proliferation of human glioblastoma cells via induction of cell cycle arrest and apoptosis

作者：Yu-Duan Tsai ; Han-Jung Chen ; Hsia-Fen Hsu ; Kang Lu ; Cheng-Loong Liang ; Po-Chou Liliang ; Kuo-Wei Wang ; Hao-Kuang Wang ; Chao-Ping Wang ; Jer-Yiing Houng

关键词：BCNU ; 1 ; 3-bis(2-chloroethyl)-1-nitrosourea ; CDK ; cyclin-dependent kinase ; EA ; ethyl acetate ; FBS ; fetal bovine serum ; FITC ; annexin-V-fluorescein isothiocyanate ; GBM ; Glioblastoma multiforme ; PARP ; poly-ADP-ribose polymerase ; PBS ; phosphate buffered saline ; PI ; propidium iodide ; PVDF ; polyvinylidene difluoride ; RT ; radiotherapy ; SDS-PAGE ; sodium dodecyl sulfate polyacrylamide gel electrophoresis ; WST-1 ; 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1 ; 3-benzene disulfonate

刊名：Journal of the Taiwan Institute of Chemical Engineers

出版年：November, 2013

9.Synergistic cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and Rana catesbeiana ribonuclease-6 in hepatoma cells

作者：Chyou-Wei Wei^a ; ^&#x2020 ; ; Pei-Lun Chou^b ; ^&#x2020 ; ; Yu-Ting Hung^a ; ^&#x2020 ; ; Giou-Teng Yiang^c ; ^d ; ^{jtyiang@ms73.hinet.net"" rel=""nofollow}

关键词：1 ; 3-Bis(2-chloroethyl)-1-nitrosourea ; Apoptosis ; Caspase ; Hepatoma cells ; Synergistic effect

刊名：Tzu Chi Medical Journal

出版年：2011

10.Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents

作者：Anna-Karin Larsson ; Abeer Shokeer ; Bengt Mannervik

关键词：Glutathione transferase (GST) ; 1 ; 3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU) ; Chloroethylnitrosoureas (CENUs) ; Directed evolution ; Alkyltransferase ; Alkylating agents

刊名：Archives of Biochemistry and Biophysics

出版年：2010

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