搜索页_5-HT6 receptor antagonists

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Elsevier电子期刊(30)

在“Elsevier电子期刊”中，命中：30条，耗时：0.0329832 秒

在所有数据库中总计命中：67条

1.Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT₆ receptor ligands with significant selectivity for D₃ over D₂ receptors

作者：Oscar M. Saavedra^a ; Delphine Karila^a ; Dominique Brossard^a ; Anne Rojas^b ; Delphine Dupuis^c ; Arnaud Gohier^d ; Clotilde Mannoury la Cour^c ; Mark J. Millan^c ; ; Jean-Claude Ortuno^b ; ; Stephen Hanessian^a ;

关键词：Benzocyclobutane ; Indole ; CNS receptors ; Schizophrenia ; Antipsychotic

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT₆ receptor antagonists

作者：Charles-Henry Fabritius^a ; Ullamari Pesonen^b ; Josef Messinger^b ; Raymond Horvath^a ; Harri Salo^b ; Michał Gałęzowski^a ; Mariusz Galek^a ; Klaudia Stefańska^a ; Joanna Szeremeta-Spisak^a ; Marta Olszak-Płachta^a ; Anna Buda^a ; Justyna Adamczyk^a ; Marcin Kró ; l^a ; Peteris Prusis^b ; Magdalena Sieprawska-Lupa^a ; Maciej Mikulski^a ; Katja Kuokkanen^b ; Hugh Chapman^b ; Radosław Obuchowicz^a ; Timo Korjamo^b ; Niina Jalava^b ; Mateusz Nowak^a ; ^{mateusz.nowak@selvita.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Serotonin receptor ; 5-HT6 receptor ; Antagonists ; Azaindole ; Cognitive impairment

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT₆ receptor antagonists. Design, synthesis and biological evaluation

作者：Anna Więckowska^a ; ^{anna.wieckowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Marcin Kołaczkowski^b ; Adam Bucki^b ; Justyna Godyń^a ; Monika Marcinkowska^b ; Krzysztof Więckowski^c ; Paula Zaręba^a ; Agata Siwek^d ; Grzegorz Kazek^e ; Monika Głuch-Lutwin^d ; Paweł Mierzejewski^f ; Przemysław Bienkowski^f ; Halina Sienkiewicz-Jarosz^f ; Damijan Knez^g ; Tomasz Wichur^a ; Stanislav Gobec^g ; Barbara Malawska^a

关键词：Alzheimer's disease ; Multi-target-directed ligands ; Acetylcholinesterase inhibitors ; Butyrylcholinesterase inhibitors ; 5-HT6 receptor antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2016

4.Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT₄R) partial agonist and 5-HT₆R antagonist activities, as potential treatment of Alzheimer’s disease

作者：Samir Yahiaoui^a ; Katia Hamidouche^b ; Cé ; line Ballandonne^a ; Audrey Davis^a ; Jana Sopkova de Oliveira Santos^a ; Thomas Freret^b ; Michel Boulouard^b ; Christophe Rochais^a ; ^{christophe.rochais@unicaen.fr" class="auth_mail" title="E-mail the corresponding author} ; Patrick Dallemagne^a ; ^{patrick.dallemagne@unicaen.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer&rsquo ; s disease ; MTDL ; 5-HT4 receptors agonists ; 5-HT6 receptors antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2016

5.Optimization of N‿(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT₆ antagonistic binding pocket

作者：Arnold van Loevezijn^&dagger ; ; ^&Dagger ; ; Jennifer Venhorst ; ^&dagger ; ; ^§ ; ; ^{jennifer.mccormack@tno.nl" class="auth_mail" title="E-mail the corresponding author} ; Wouter I. Iwema Bakker^¶ ; ; Jos H.M. Lange^‖ ; Wouter de Looff^&dagger ; &dagger ; ; Remco Henzen ; Jelle de Vries^&Dagger ; &Dagger ; ; Rob P. van de Woestijne ; Arnold P. den Hartog^§ ; § ; ; Stefan Verhoog^¶ ; ¶ ; ; Martina A.W. van der Neut^‖‖ ; Natasja M.W.J. de Bruin^&dagger ; &dagger ; &dagger ; ; Chris G. Kruse^&Dagger ; &Dagger ; &Dagger ;

关键词：5-HT6 receptor ; N&prime ; -(Arylsulfonyl)pyrazoline-1-carboxamidines ; Non-basic 5-HT6 antagonists ; Molecular modeling

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT₆ receptor agonists

作者：Cecilia Mattsson^a ; ^{cecilia.m.mattsson@gmail.com} ; Peder Svensson^a ; ¹ ; ^{peder.svensson@astrazeneca.com} ; Henning Boettcher^b ; ^{henning.boettcher@merckgroup.com} ; Clas Sonesson^a ; ^{clas.sonesson@gmail.com}

关键词：5-HT6 ; 5-Hydroxytryptamine type 6 receptor agonist ; 3-(123 ; 6-Tetrahydropyridin-4-yl)-1H-indole ; EMD386088

刊名：European Journal of Medicinal Chemistry

出版年：2013

7.Design and synthesis of novel series of 5-HT₆ receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group

作者：Faisal Hayat ; Sungjin Cho ; Hyewhon Rhim ; Ambily Nath Indu Viswanath ; Ae Nim Pae ; Jae Yeol Lee ; Dong Joon Choo ; Hea-Young Park Choo

关键词：5-HT6 receptor antagonist ; 1-Amino-4-methylpiperazine ; Sulfonyl indole ; 3D QSAR ; Pharmacophore mapping

刊名：Bioorganic and Medicinal Chemistry

出版年：2013

8.Synthesis and biological evaluation of benzoisothiazole derivatives possessing N,N-dimethylformimidamide group as 5-HT₆ receptor antagonists

作者：Euna Yoo^a ; Faisal Hayat^a ; Hyewhon Rhim^b ; ^{hrhim@kist.re.kr} ; Hea-Young Park Choo^a ; ^{hypark@ewha.ac.kr}

关键词：5-HT6 receptor antagonists ; Benzoisothiazole ; Sulfonamide ; N ; N-dimethylformimidamide

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

9.Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists

作者：Shuanghua Hu^a ; ^{shuanghua.hu@bms.com" class="auth_mail} ; Yazhong Huang^a ; Yong-Jin Wu^a ; Huan He^a ; Katherine A. Grant-Young^a ; Robert L. Bertekap^b ; Valerie Whiterock^c ; Patrick Brassil^c ; Kimberley Lentz^c ; Prasanna Sivaprakasam^d ; David R. Langley^d ; Ryan S. Westphal^b ; Paul M. Scola^a

关键词：5-HT6 antagonist ; Cognition ; Alzheimer&rsquo ; s disease ; Feeding behavior ; Obesity

刊名：Bioorganic and Medicinal Chemistry

出版年：1 March, 2014

10.Antagonists of 5-HT₆ receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines¡ªSynthesis and ¡®structure-activity?relationship

作者：Alexandre V. Ivachtchenko^a ; ^b ; Elena S. Golovina^a ; Madina G. Kadieva^a ; Volodymyr M. Kysil^b ; Oleg D. Mitkin^a ; Anton A. Vorobiev^a ; Ilya Okun^b ; ^{iokun@chemdiv.com}

关键词：Serotonin receptor 5-HT6 ; Antagonists ; Phenylsulfonyl-pyrazolo-pyrido-pyrimidines ; Specificity ; hERG channel

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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