作者：Taeko Kubo ; DVM ; PhD^a ; ^b ; ^c ; ^{taeko-kubo@ds-pharma.co.jp} ; ^{taekok2016@gmail.com} ; Takashi Ashihara ; MD ; PhD^b ; Tadashi Tsubouchi ; PhD^a ; Minoru Horie ; MD ; PhD^b

关键词：AP ; action potential ; APD ; action potential duration ; APD30 ; APD at 30% repolarization ; APD90 ; APD at 90% repolarization ; APD30&ndash ; 90 ; APD90&ndash ; APD30 ; [Ca2  ; +]i ; intracellular Ca2  ; + concentration ; CiPA ; Comprehensive in vitro Proarrhythmia Assay ; CV ; conduction velocity ; EAD ; early afterdepolarization ; ECG ; electrocardiogram ; Endo ; endocardial ; Epi ; epicardial ; FH ; failing heart ; ICH ; International Conference of Harmonization ; IQ-CSRC ; Innovation and Quality in Pharmaceutical Deve

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

作者：Wenlu Xing^a ; Chuanyu Gao^a ; ^{gaocy6208@163.com} ; Datun Qi^a ; ^c ; You Zhang^b ; Peiyuan Hao^a ; Guoyou Dai^a ; Ganxin Yan^a ; ^c

关键词：VEGF ; vascular endothelial growth factor ; LTCC ; L-type calcium channel ; VEGFR2 ; VEGF type-2 receptor ; ICaL ; L-type calcium currents ; AP ; action potential ; APD ; action potential duration ; EC coupling ; excitation-contraction coupling ; IV ; current-voltage

刊名：Biomedicine & Pharmacotherapy

出版年：2017

作者：Gerrit Frommeyer^a ; ^{gerrit.frommeyer@ukmuenster.de} ; Anja Kohnke^a ; Christian Ellermann^a ; Dirk G. Dechering^a ; Simon Kochhä ; user^a ; Christian Pott^a ; Michael Fehr^b ; Lars Eckardt^a

关键词：Levosimendan ; Therapeutic safety ; Ventricular refractory period ; Ventricular fibrillation

刊名：International Journal of Cardiology

出版年：2017

作者：John Ford ; PhD^* ; James Milnes ; PhD^* ; Said El Haou ; PhD^* ; Erich Wettwer ; PhD^&dagger ; ; Simone Loose ; MD^&dagger ; ; Klaus Matschke ; MD^&Dagger ; ; Benoit Tyl ; MD^§ ; ; Patrick Round ; MBBS^* ; Ursula Ravens ; MD^&dagger ; ; ^{ravens@rcs.urz.tu-dresden.de" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; ANOVA ; analysis of variance ; AP ; action potential ; APA ; action potential amplitude ; APD20 ; APD50 ; APD90 ; action potential duration at 20% ; 50% ; and 90% of repolarization ; cAF ; chronic atrial fibrillation ; DMSO ; dimethyl sulfoxide ; dV/dtmax ; maximum upstroke velocity ; ECG ; electrocardiogram/electrocardiographic ; ERP ; effective refractory period ; HR ; heart rate ; IKur ; ultra-rapidly activating delayed-rectifier potassium current ; pAF ; paroxysmal atrial fibrillation ; PLT20

刊名：Heart Rhythm

出版年：2016

作者：Balá ; zs Horvá ; th^a ; ^b ; ¹ ; Krisztina Vá ; czi^a ; ¹ ; Bence Hegyi^a ; Mó ; nika Gö ; nczi^a ; ^c ; Beatrix Dienes^a ; Korné ; l Kistamá ; s^a ; Tamá ; s Bá ; nyá ; sz^a ; Já ; nos Magyar^a ; ^d ; Istvá ; n Baczkó ; ^e ; Andrá ; s Varró ; ^e ; ^f ; Gyö ; rgy Sepré ; nyi^g ; Lá ; szló ; Csernoch^a ; Pé ; ter P. Ná ; ná ; si^a ; ^h ; Norbert Szentandrá ; ssy^a ; ^h ; ^{szentandrassy.norbert@med.unideb.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：9-AC ; 9-anthracene carboxylic acid ; AP ; action potential ; APVC ; action potential voltage-clamp ; APD90 ; action potential duration at 90% of repolarization ; BKCa ; large-conductance Ca2+-activated K+ channels ; CaT ; calcium transient ; Cav1.2 ; pore forming subunit of L-type Ca2+ channel ; [Ca2+]cleft ; Ca2+ concentration in the dyadic cleft ; [Ca2+]i ; intracellular Ca2+ concentration in bulk cytoplasm ; [Cl&minus ; ]i ; intracellular Cl&minus ; concentration ; CDI ; Ca2+-dependent inactivation ; CICR ; Ca2+-indu

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

作者：Guy Page^a ; Phachareeya Ratchada^a ; Yannick Miron^a ; Guido Steiner^b ; Andre Ghetti^a ; Paul E. Miller^a ; Jack A. Reynolds^a ; Ken Wang^b ; Andrea Greiter-Wilke^b ; Liudmila Polonchuk^b ; Martin Traebert^c ; Gary A. Gintant^d ; Najah Abi-Gerges^a ; ^{Najah.abigerges@anabios.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Human heart ; Ventricular trabeculae ; Action potential ; Pro-arrhythmia assessment ; Drug discovery and development

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

作者：Lucia Romero^a ; ^{lurope@eln.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Beatriz Trenor^a ; ^{btrenor@eln.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Pei-Chi Yang^b ; ^{pcyang@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author} ; Javier Saiz^a ; ^{jsaiz@gbio.i3bh.es" class="auth_mail" title="E-mail the corresponding author} ; Colleen E. Clancy^b ; ^{ceclancy@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：aLQTS ; drug-induced or acquired long-QT syndrome ; AP ; action potential ; APD ; action potential duration ; APD90 ; action potential duration at 90% repolarization ; C1 ; closed state 1 ; C2 ; closed state 2 ; C3 ; closed state 3 ; EAD ; early-afterdepolarization ; ECG ; electrocardiogram ; I ; inactivated state ; IKr ; rapid component of the delayed rectifier current ; LQTS ; long-QT syndrome ; O ; open state ; RFI ; recovery from inactivation ; TdP ; torsade de pointes ; WT ; wild-type ; Actilide_Oc ; drug binding simultane

刊名：Journal of Molecular and Cellular Cardiology

出版年：2015

作者：Icilio Cavero^a ; ^{iciliocavero@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Henry Holzgrefe^b

关键词：AERS ; adverse event reporting system ; AP ; action potential ; APD ; action potential duration ; APD50 ; Action Potential Duration at 50% depolarization ; APD90 ; Action Potential Duration at 90% depolarization ; BP ; Beating Period ; BR ; Beating Rate or Rhythm ; Ca50 ; calcium transient amplitude at 50% of maximal activation ; Ca90 ; calcium transient amplitude at 90% of maximal activation ; CiPA ; comprehensive in vitro proarrhythmia assay ; CDER ; Center for Drug Evaluation and Research ; CTWG ; Clinical Translat

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2015

刊名：Journal of the American College of Cardiology

出版年：2015

作者：Asma Mechakra ; Yohann Vincent ; Philippe Chevalier ; Gilles Millat ; Eckhard Ficker ; Marek Jastrzebski ; Hugo Poulin ; Val茅rie Pouliot ; Mohamed Chahine ; Georges Christ茅

关键词：APD ; Action potential duration ; APD90 ; APD at 90% repolarization ; DNA ; Deoxyribonucleic acid ; cDNA ; Cyclic DNA ; ECG ; Electrocardiogram ; ESP ; Exome Sequencing Project ; HEK293 ; Human-derived renal epithelial cell line number 293 ; hERG ; Human ether-à ; -go-go related gene ; IKr ; The rapid delayed rectifier current ; underlied in cardiac cells by hERG ; LQTS ; Long QT syndrome ; PAS domain ; Per-Arnt-Sim domain in the N-terminal branch of the hERG protein ; QT ; The QT interval of the ECG ; QTc ; The corr

刊名：Gene

出版年：25 February, 2014