搜索页_B-Raf+kinase+inhibitor

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在“Elsevier电子期刊”中，命中：1,383条，耗时：0.040014 秒

在所有数据库中总计命中：1,664条

1.Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells

作者：Yin Chen^a ; ¹ ; Yaxin Zheng^a ; ¹ ; Qinglin Jiang^a ; ^b ; ¹ ; Feifei Qin^a ; Yonghui Zhang^c ; Leilei Fu^a ; ^{leilei_fu@163.com} ; Gu He^a ; ^{hegu@scu.edu.cn}

关键词：Breast cancer ; Raf ; ERK ; Bioinformatics ; Kinase inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Cutaneous Adverse Events of New Anti-melanoma Therapies: Classification and Management

作者：S.J.E. Hwang^a ; ^b ; ^{shelley.hwang@hotmail.com} ; R. Anforth^a ; ^b ; G. Carlos^a ; ^b ; P. Fernandez-Peñ ; as^a ; ^b

关键词：B-Raf inhibitors ; Mitogen-activated protein kinase inhibitor ; Anti-Cytotoxic T-lymphocyte-associated protein 4 ; Anti-Programmed cell death-1 ; Metastatic melanoma ; Cutaneous adverse event

刊名：Actas Dermo-Sifiliográficas (English Edition)

出版年：2017

3.Cutaneous Adverse Events of New Anti-melanoma Therapies: Classification and Management

作者：S.J.E. Hwang^a ; ^b ; ^{shelley.hwang@hotmail.com} ; R. Anforth^a ; ^b ; G. Carlos^a ; ^b ; P. Fernandez-Peñ ; as^a ; ^b

刊名：Actas Dermo-Sifiliográficas

出版年：2017

4.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

5.A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus

作者：Renfu Yin^a ; ^{yin@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xinxin Liu^b ; Pingze Zhang^a ; Yanyu Chen^a ; Guangyao Xie^a ; Lili Ai^a ; Cong Xue^a ; Jing Qian^a ; Yuhai Bi^c ; Jianjun Chen^d ; Yuzhang Sun^e ; Tobias Stoeger^f ; Zhuang Ding^a ; ^{dingzhuang@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Newcastle disease virus ; Raf kinase inhibitor V ; Antivirals ; Raf kinase

刊名：Antiviral Research

出版年：2016

6.Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-Raf^V600E and C-Raf kinase inhibitory activities

作者：Ashraf Kareem El-Damasy^a ; ^b ; ^c ; Ju-Hyeon Lee^a ; Seon Hee Seo^a ; Nam-Chul Cho^a ; ^d ; Ae Nim Pae^a ; ^b ; Gyochang Keum^a ; ^b ; ^{gkeum@kist.re.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Anticancer activity ; Benzothiazole ; Urea ; Amide ; Pyridylamide ; B-RafV600E ; C-Raf

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.GSK114: A selective inhibitor for elucidating the biological role of TNNI3K

作者：Brian G. Lawhorn^a ; ^{brian.2.lawhorn@gsk.com" class="auth_mail" title="E-mail the corresponding author} ; Joanne Philp^a ; Alan P. Graves^b ; Lisa Shewchuk^b ; Dennis A. Holt^a ; Gregory J. Gatto Jr.^a ; Lara S. Kallander^a

关键词：TNNI3K ; B-Raf ; Quinazoline ; Substituent effects ; Kinase selectivity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation

作者：Silvana Sandri^a ; ¹ ; Fernanda Faiã ; o-Flores^a ; ¹ ; Manoela Tiago^a ; Paula Comune Pennacchi^a ; Renato Ramos Massaro^a ; Dé ; bora Kristina Alves-Fernandes^a ; Gustavo Noriz Berardinelli^b ; Adriane Feijó ; Evangelista^b ; Vinicius de Lima Vazquez^b ; ^c ; Rui Manuel Reis^b ; ^d ; ^e ; Silvya Stuchi Maria-Engler ; Ph.D.^a ; ^{silvya@usp.br" class="auth_mail" title="E-mail the corresponding author}

关键词：BRAF ; v-Raf murine sarcoma viral oncogene homolog B ; MAPK ; mitogen-activated protein kinases ; MMP ; matrix metalloproteinase ; ECM ; extracellular matrix ; IL-8 ; interleukin 8 ; EGFR ; epidermal growth factor receptor ; TIMP-2 ; metallopeptidase-2 or tissue inhibitor of metalloproteinases ; RECK ; reversion-inducing-cysteine-rich protein with kazal motifs ; PDGFRβ ; platelet-derived growth factor-activated receptor beta ; IGF1R ; insulin-like growth factor 1 receptor ; NRG ; neuregulin-1 ; WNT5A ; wingless-type M

刊名：Pharmacological Research

出版年：2016

9.Liquid chromatography⿿tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O⿿desmethyl metabolites of erlotinib and gefitinib in human plasma

作者：Rolf W. Sparidans^a ; ^b ; ^{R.W.Sparidans@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Hilde Rosing^c ; ^{H.Rosing@nki.nl" class="auth_mail" title="E-mail the corresponding author} ; Johannes J.M. Rood^a ; ^{J.J.M.Rood@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Jan H.M. Schellens^a ; ^d ; ^{j.schellens@nki.nl" class="auth_mail" title="E-mail the corresponding author} ; Jos H. Beijnen^a ; ^c ; ^d ; ^{jos.beijnen@slz.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：EGFR ; epidermal growth factor receptor ; IS ; internal standard ; LC⿿MS/MS ; liquid chromatography⿿tandem mass spectrometry ; LLOQ ; lower limit of quantification ; SRM ; selected reaction monitoring ; QC ; quality control

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2016

10.Discovery of EBI-907: A highly potent and orally active B-Raf^V600E inhibitor for the treatment of melanoma and associated cancers

作者：Biao Lu^a ; ; Hu Cao^a ; Jingsong Cao^b ; Song Huang^a ; Qiyue Hu^a ; Dong Liu^b ; Ru Shen^b ; Xiaodong Shen^a ; Weikang Tao^a ; Hong Wan^a ; Dan Wang^a ; Yinfa Yan^b ; Liuqing Yang^b ; Jiayin Zhang^b ; Lei Zhang^a ; Lianshan Zhang^c ; Minsheng Zhang^b

关键词：B-RafV600E ; Kinase ; Pyrazolo[3 ; 4-c]isoquinoline ; Scaffold hopping ; Cancer

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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