搜索页_B-Raf+kinase+inhibitors

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在“Elsevier电子期刊”中，命中：1,206条，耗时：0.0359878 秒

在所有数据库中总计命中：1,403条

1.Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells

作者：Yin Chen^a ; ¹ ; Yaxin Zheng^a ; ¹ ; Qinglin Jiang^a ; ^b ; ¹ ; Feifei Qin^a ; Yonghui Zhang^c ; Leilei Fu^a ; ^{leilei_fu@163.com} ; Gu He^a ; ^{hegu@scu.edu.cn}

关键词：Breast cancer ; Raf ; ERK ; Bioinformatics ; Kinase inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Cutaneous Adverse Events of New Anti-melanoma Therapies: Classification and Management

作者：S.J.E. Hwang^a ; ^b ; ^{shelley.hwang@hotmail.com} ; R. Anforth^a ; ^b ; G. Carlos^a ; ^b ; P. Fernandez-Peñ ; as^a ; ^b

关键词：B-Raf inhibitors ; Mitogen-activated protein kinase inhibitor ; Anti-Cytotoxic T-lymphocyte-associated protein 4 ; Anti-Programmed cell death-1 ; Metastatic melanoma ; Cutaneous adverse event

刊名：Actas Dermo-Sifiliográficas

出版年：2017

3.Cutaneous Adverse Events of New Anti-melanoma Therapies: Classification and Management

作者：S.J.E. Hwang^a ; ^b ; ^{shelley.hwang@hotmail.com} ; R. Anforth^a ; ^b ; G. Carlos^a ; ^b ; P. Fernandez-Peñ ; as^a ; ^b

刊名：Actas Dermo-Sifiliográficas (English Edition)

出版年：2017

4.Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14⁺⁺CD16⁻) monocytes via PI3K/Akt/mTOR-dependent signalling pathway

作者：Marzena Lenart^a ; Magdalena Rutkowska-Zapala^a ; Monika Baj-Krzyworzeka^a ; Rafał Szatanek^a ; Kazimierz Węglarczyk^a ; Timothy Smallie^b ; Lö ; ms Ziegler-Heitbrock^c ; ^d ; Marek Zembala^a ; Maciej Siedlar^a ; ^{misiedla@cyf-kr.edu.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：DCs ; dendritic cells ; HA ; hyaluronan ; IRF ; interferon regulatory factor ; MOI ; multiplicity of infection ; PKB ; protein kinase B ; RNI ; reactive nitrogen intermediates ; ROI ; reactive oxygen species ; mTOR ; mammalian target of rapamycin ; TIM ; tumor-infiltrating monocytes/macrophages ; TMV ; tumor microvesicles

刊名：Immunobiology

出版年：2017

5.Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies

作者：Alessandro Papale^a ; Raffaele d&rsquo ; Isa^b ; ¹ ; Elisabetta Menna^c ; ^e ; ¹ ; Milica Cerovic^a ; ^d ; Nicola Solari^b ; ^d ; Neil Hardingham^a ; Marco Cambiaghi^b ; Marco Cursi^b ; Mariano Barbacid^f ; Letizia Leocani^b ; Stefania Fasano^a ; ^b ; Michela Matteoli^c ; ^e ; Riccardo Brambilla^a ; ^b ; ^{brambillar@cf.ac.uk}

关键词：ERK ; GABAergic synaptogenesis ; Intellectual disability ; KRAS ; Pharmacological rescue ; RASopathies

刊名：Biological Psychiatry

出版年：2017

6.Murine colitis treated with multitargeted tyrosine kinase inhibitors

作者：Jennifer Leslie Knod ; MD ; Kelly Crawford ; BS ; Mary Dusing ; BS ; Jason S. Frischer ; MD ; ^{Jason.Frischer@cchmc.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Inflammatory bowel disease ; Colitis ; Angiogenesis ; VEGF ; Receptor tyrosine kinase inhibitors

刊名：Journal of Surgical Research

出版年：2016

7.Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors

作者：Vladimir Simov^a ; ^{vladimir_simov@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Sujal V. Deshmukh^c ; Christopher J. Dinsmore^b ; Fiona Elwood^a ; Rafael B. Fernandez^a ; Yudith Garcia^a ; Craig Gibeau^a ; Hakan Gunaydin^a ; Joon Jung^d ; Jason D. Katz^a ; Brian Kraybill^e ; Blair Lapointe^a ; Sangita B. Patel^a ; Tony Siu^a ; Hua Su^a ; Jonathan R. Young^f

关键词：Janus Kinase ; JAK1 kinase inhibitor ; Structure-based design

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators

作者：Barbara Capuani^a ; Francesca Pacifici^a ; Donatella Pastore^a ; Raffaele Palmirotta^b ; Giulia Donadel^a ; Roberto Arriga^a ; Alfonso Bellia^a ; Nicola Di Daniele^a ; Paola Rogliani^a ; Pasquale Abete^c ; Paolo Sbraccia^a ; Fiorella Guadagni^d ; ^e ; Davide Lauro^a ; David Della-Morte ; PhD^a ; ^d ; ^{david.dellamorte@uniroma2.it" class="auth_mail" title="E-mail the corresponding author} (MD)

关键词：PKC ; protein kinase C ; IPC ; ischemic pre conditioning ; RACK ; receptor for activated C-kinase ; DAG ; diacylglycerol ; beta COP ; coatomer subunit beta ; CHOK1 ; chinese hamster ovary K1 ; CVD ; cardiovascular disease ; mKATP ; ATP-sensitive mitochondrial potassium channels ; VSMC ; vascular smooth muscle cell ; CPK ; creatinine phosphokinase ; PI3-K ; phosphatidylinositol-3-kinase ; OGD ; oxygen glucose deprivation ; ERK ; extracellular signal-regulated kinase ; A1AR ; adenosine A1 receptors ; NMDA ; N-methyl-d-asparta

刊名：Pharmacological Research

出版年：2016

9.Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridin-4-yl)vinyl)quinoxalinone derivates as potent VEGFR-2 kinase inhibitors

作者：Leilei Shi^a ; Jianfeng Zhou^b ; Jifeng Wu^c ; Junya Cao^d ; Yuemao Shen^a ; Hua Zhou^e ; Xun Li^a ; ^{tjulx2004@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：VEGFR-2 inhibitor ; Quinoxalinone derivates ; Antiangiogenesis ; Pyridyl motif ; Activity evaluation

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Discovery of N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives as potential antiproliferative agents by inhibiting MEK

作者：Xian-Hai Lv^a ; ^b ; Zi-Li Ren^b ; Ben-Guo Zhou^b ; Qing-Shan Li^c ; Ming-Jie Chu^a ; Dao-Hong Liu^a ; Kai Mo^a ; Li-Song Zhang^a ; Xiao-Kang Yao^a ; Hai-Qun Cao^b ; ^{haiquncao@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：MEK ; mitogen-activated protein kinase ; BRAF ; V-RAF murine sarcoma viral oncogene homologue B1 ; ERK ; extracellular regulated kinase ; BRAFV600E ; V600E mutant BRAF ; BRAFV600K ; V600K mutant BRAF ; IC50 ; half maximal inhibitory concentration ; GI50 ; the concentration that causes 50% growth inhibition ; SAR ; structure&ndash ; activity relationship

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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