搜索页_Botulinum+neurotoxin+assay

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

Wiley电子期刊(1)	NATURE电子期刊(3)	ACS电子期刊(27)
SpringerLink电子期刊(27)	Elsevier电子期刊(181)

在“Elsevier电子期刊”中，命中：181条，耗时：0.0209925 秒

在所有数据库中总计命中：239条

1.A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A

作者：William A. Harrell Jr.^a ; ^d ; Rebecca C. Vieira^a ; ^e ; Susan M. Ensel^b ; Vicki Montgomery^a ; Rebecca Guernieri^a ; Vanessa S. Eccard^a ; ^f ; Yvette Campbell^a ; Virginia Roxas-Duncan^a ; ^g ; John H. Cardellina II^a ; ^h ; Robert P. Webb^a ; ^{robert.p.webb6.civ@mail.mil} ; Leonard A. Smith^c

关键词：BoNTs ; botulinum neurotoxins ; BoNT/A ; botulinum neurotoxin serotype A ; HC ; heavy chain ; LC ; light chain ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; SNAP-25 ; 25 ; kDa synaptosomal-associated protein ; BIG-IV ; Botulism Immune Globulin Intravenous (Human) ; SAR ; structure-activity relationship ; IC50 ; 50% inhibitory concentration ; MPNHDA ; mouse phrenic nerve hemidiaphragm assay

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics

作者：Emina Wild^a ; Ursula Bonifas^a ; Jolanta Klimek^a ; Jan-Hendrik Trö ; semeier^b ; ^c ; Beate Krä ; mer^a ; Birgit Kegel^a ; Heike A. Behrensdorf-Nicol^a ; ^{Heike.Behrensdorf@pei.de" class="auth_mail" title="E-mail the corresponding author}

关键词：BINACLE ; binding and cleavage assay ; BoNT ; botulinum neurotoxin ; BSA ; bovine serum albumin ; GT1b ; ganglioside GT1b ; H-chain ; heavy chain ; HCc ; C-terminal region of the H-chain ; L-chain ; light chain ; LD50 ; lethal dose for 50% of test animals ; NAP ; neurotoxin-associated protein ; PBS ; phosphate-buffered saline ; PIPES ; piperazine-N ; N&prime ; -bis(2-ethanesulfonic acid) ; Syt ; synaptotagmin peptide ; TCEP ; tris(2-carboxyethyl)phosphine ; TMAO ; trimethylamine N-oxide ; TMB ; 3 ; 3&prime5 ; 5&prime ; -tetramethyl

刊名：Toxicology in Vitro

出版年：2016

3.Submolecular recognition regions of the H_N domain of the heavy chain of botulinum neurotoxin type A by T cells from toxin-treated cervical dystonia patients

作者：Minako Oshima^a ; Philip Deitiker^a ; Joseph Jankovic^c ; M Zouhair Atassi^a ; ^b ; ^{matassi@bcm.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Ab ; antibody ; BoNT/A ; botulinum neurotoxin type A ; BoNT/Ai ; inactivated BoNT/A ; BoNT/B ; botulinum neurotoxin type B ; CD ; cervical dystonia ; L chain ; the light chain (residues 1&ndash ; 448) of BoNT ; HLA ; human leukocyte antigen ; H chain ; the heavy chain (residues 449&ndash ; 1296) of BoNT ; HC ; C-terminal domain (residues 855&ndash ; 1296) of H chain ; HN ; N-terminal domain (residues 449&ndash ; 859) of H chain ; MPA ; mouse protection assay ; PBL ; peripheral blood lymphocytes ; PBS ; 0.15 ; M NaCl in 0.01&

刊名：Journal of Neuroimmunology

出版年：2016

4.Submolecular recognition of the C-terminal domain of the heavy chain of botulinum neurotoxin type A by T cells from toxin-treated cervical dystonia patients

作者：Minako Oshima^a ; Philip Deitiker^a ; Joseph Jankovic^c ; K. Roger Aoki^d ; M. Zouhair Atassi^a ; ^b ; ^{matassi@bcm.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Ab ; antibody ; BoNT/A ; botulinum neurotoxin type A ; BoNT/Ai ; inactivated BoNT/A ; BoNT/B ; botulinum neurotoxin type B ; CD ; cervical dystonia ; L chain ; the light chain (residues 1&ndash ; 448) of BoNT/A ; HLA ; human leukocyte antigen ; H chain ; the heavy chain (residues 449&ndash ; 1296) of BoNT/A ; HC ; C-terminal domain (residues 855&ndash ; 1296) of H chain ; LNC ; lymph node cells ; MPA ; mouse protection assay ; PBL ; peripheral blood lymphocytes ; PBS ; 0.15 ; M NaCl in 0.01 ; M sodium phosphate buffer

刊名：Immunobiology

出版年：2016

5.In-vivo comparison of the neurotoxic potencies of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA

作者：Anna Kutschenko ; ^{anna.kutschenko@med.uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author} ; Anja Manig ; Marie-Christine Reinert ; Angelika Mö ; nnich ; David Liebetanz

关键词：BoNT ; botulinum neurotoxin ; BoNT/A-G ; botulinum neurotoxin type A-G ; A/Inco ; incobotulinumtoxinA (Xeomin®) ; A/Ona ; onabotulinumtoxinA (Botox®) ; A/Abo ; abobotulinumtoxinA (Dysport®) ; DAS assay ; digit abduction score assay ; MU ; mouse unit ; Vmax ; maximum running velocity ; ANOVA ; analysis of variance

刊名：Neuroscience Letters

出版年：2016

6.Nerve cell-mimicking liposomes as biosensor for botulinum neurotoxin complete physiological activity

作者：Oliver G. Weingart ; ^{Oliver.Weingart@hest.ethz.ch} ; Martin J. Loessner

关键词：In vitro ; Botulinum neurotoxin ; Liposome ; Potency testing ; Animal testing alternatives

刊名：Toxicology and Applied Pharmacology

出版年：2016

7.Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography

作者：Desigan Kumaran^a ; Michael Adler^b ; ^{michael.adler2.civ@mail.mil" class="auth_mail" title="E-mail the corresponding author} ; Matthew Levit^b ; Michael Krebs^b ; Richard Sweeney^c ; Subramanyam Swaminathan^a

关键词：BoNT ; botulinum neurotoxin ; Balc ; botulinum neurotoxin A light chain ; Balc424 ; Balc truncated at residue 424 ; Balc448 ; full-length Balc ; CPI-1 ; cyclic peptide inhibitor-1 ; CPI-2 ; cyclic peptide inhibitor-2 ; DAB ; 2 ; 4-diaminobutanoic acid ; FRET ; Fö ; rster resonance energy transfer ; HBAT ; hepatavalent botulism antitoxin ; LC ; light chain ; PDB ; protein data bank ; PLM ; peptide-like molecule ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; SNAP-25 ; synaptosome-associate

刊名：Bioorganic & Medicinal Chemistry

出版年：2015

8.Improved detection of botulinum type E by rational design of a new peptide substrate for endopeptidase-mass spectrometry assay

作者：Osnat Rosen^a ; Liron Feldberg^b ; Sigalit Gura^b ; Ran Zichel^a ; ^{ranz@iibr.gov.il" class="auth_mail}

关键词：Botulinum neurotoxin ; Detection ; UPLC ; Mass spectrometry ; Peptide substrate

刊名：Analytical Biochemistry

出版年：1 July 2014

9.Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

作者：Jasmin Strotmeier^a ; Stefan Mahrhold^a ; ^b ; Nadja Krez^a ; Constantin Janzen^a ; Jianlong Lou^c ; James D. Marks^c ; Thomas Binz^b ; Andreas Rummel^a ; ^{Rummel.Andreas@mh-hannover.de" class="auth_mail}

关键词：BoNT ; botulinum neurotoxin ; GBS ; ganglioside binding site ; GST ; glutathion-S-transferase ; HC ; heavy chain ; HC ; carboxyl-terminal half of HC ; HCA ; HCE ; HCF ; HCG ; HCX ; HC fragment of BoNT serotype A ; E ; F ; G or A-G respectively ; HN ; amino-terminal half of HC ; H6F3HCXS ; N-terminal 6× ; His tag ; 3× ; Flag tag ; HC fragment of serotype A-G ; C-terminal Streptag ; LC ; light chain ; mAb ; monoclonal antibody ; MPN assay ; mice phrenic nerve hemidiaphragm assay ; scFv ; single-chain variable fragments ; r

刊名：FEBS Letters

出版年：2 April, 2014

10.Reduction of established antibody responses against botulinum neurotoxin A by synthetic monomethoxypolyethylene glycol peptide conjugates

作者：M. Zouhair Atassi^a ; ^b ; ^{matassi@bcm.edu" class="auth_mail} ; Masooma Naqvi^a ; Behzod Z. Dolimbek^a ; K. Roger Aoki^c

关键词：Ab ; antibody ; BoNT/A ; botulinum neurotoxin serotype A ; BSA ; bovine serum albumin ; H-chain ; the heavy chain (residues 449&ndash ; 1296) of BoNT/A ; HC ; peptide numbers preceded by C indicate peptides of the C-terminal domain (residues 855&ndash ; 1296) of the H-chain of BoNT/A ; HN ; peptides denoted by N indicate peptides of the N-terminal domain (residues 449&ndash ; 859) of the H-chain of BoNT/A ; mPEG ; monomethoxypolyethylene glycol ; MPA ; mouse protection assay ; PBS ; 0.15 ; M NaCl in 0.01 ; M sod

刊名：Journal of Neuroimmunology

出版年：15 July 2014

按检索点细分(181)

题名(36)

关键词(40)

文摘(131)

按出版年细分(181)

2027年及以后(6)

2017年(1)

2016年(5)

2015年(1)

2013年(8)

2012年(17)

2011年(22)

2010年(11)

2009年(13)

2008年(21)

2007年(15)

2006年(13)

2005年(7)

2004年(8)

2003年(5)

2002年(4)

2001年(4)

2000年(3)

2000年及以前(17)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700