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Elsevier电子期刊(71)

在“Elsevier电子期刊”中，命中：71条，耗时：小于0.01 秒

在所有数据库中总计命中：91条

1.Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists

作者：Maria Antonia Buil^a ; Marta Calbet^a ; Marcos Castillo^b ; Jordi Castro^a ; Cristina Esteve^a ; Manel Ferrer^a ; Pilar Forns^b ; Jacob Gonzá ; lez^a ; Sara Ló ; pez^a ; Richard S. Roberts^a ; ¹ ; ^{rick.roberts@almirall.com" class="auth_mail" title="E-mail the corresponding author} ; Sara Sevilla^a ; Bernat Vidal^a ; Laura Vidal^a ; Pere Vilaseca^a

关键词：CRTh2 antagonist ; Receptor residence time ; Structure-activity relationship (SAR) ; Structure-kinetic relationship (SKR)

刊名：European Journal of Medicinal Chemistry

出版年：2016

2.Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy

作者：Marta Calbet ; ^{marta.calbet@almirall.com" class="auth_mail" title="E-mail the corresponding author} ; Miriam Andrés ; Clara Armengol ; Mó ; nica Bravo ; Peter Eichhorn ; Rosa Ló ; pez ; Vicente Garcí ; a-Gonzá ; lez ; Richard Roberts ; Montserrat Miralpeix

关键词：cAMP ; cyclic adenosine monophosphate ; CHO ; chinese hamster ovary cell line ; CRTh2 ; chemoattractant receptor-homologous molecule expressed on T-helper cells ; DK-PGD2 ; 13-14-dihydro-15-keto-PGD2 ; GDP ; guanosine diphosphate ; GPCR ; G protein-coupled receptor ; GTP ; guanosine triphosphate ; PGD2 ; prostaglandin D2 ; PMN ; polymorphonuclear cells ; Th2 ; T-helper cells type 2

刊名：Pharmacological Research

出版年：2016

3.Data on the oral CRTh2 antagonist QAW039 (fevipiprant) in patients with uncontrolled allergic asthma

作者：Veit J. Erpenbeck^a ; ^{veit.erpenbeck@novartis.com} ; Todor A. Popov^b ; David Miller^c ; Steven F. Weinstein^d ; Sheldon Spector^e ; Baldur Magnusson^a ; Wande Osuntokun^f ; Paul Goldsmith^f ; Markus Weiss^a ; Jutta Beier^g

刊名：Data in Brief

出版年：2016

4.The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma

关键词：Asthma ; Chemoattractant receptor-homologous molecule expressed on Th2 cells ; Clinical trial

刊名：Pulmonary Pharmacology & Therapeutics

出版年：2016

5.Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts

作者：Kengo Kanai^a ; ^b ; Mitsuhiro Okano^a ; ^{mokano@cc.okayama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tazuko Fujiwara^a ; Shin Kariya^a ; Takenori Haruna^a ; Ryotaro Omichi^a ; Sei-ichiro Makihara^c ; Yuji Hirata^b ; Kazunori Nishizaki^b

关键词：CRTH2 ; DP ; Nasal polyp fibroblast ; PGD2 ; VEGF

刊名：Allergology International

出版年：2016

6.Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases

作者：Jatinder Singh¹ ; Ramanpreet Shah¹ ; Dhandeep Singh ; ^{ddd300@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AP1 ; Activator protein 1 ; cAMP ; Cyclic adenosine monophoshate ; CXCR ; Cytokine receptors ; CRTH2 ; Chemoattractant receptor-homologous molecule expressed on Th2 cells ; DAMPs ; Damage-associated molecular pattern ; EtBr ; Ethidium Bromide ; IgE ; Immunoglobulin E ; IKK ; IκB kinase ; IRF3 ; Interferon regulatory factor 3 ; LAT ; linker for activation of T cells ; LYN ; Tyrosine-protein kinase ; MAP3Ks ; Mitogen-activated protein kinase kinase kinases ; NFκB ; Nuclear factor kappa B ; NTAL ; Non-T-cell activation linke

刊名：International Immunopharmacology

出版年：2016

7.Prostaglandin D₂ is a novel repressor of IFNγ induced indoleamine-2,3-dioxygenase via the DP1 receptor and cAMP pathway

作者：Nesrine Kamal Bassal ; Bernard P Hughes ; Maurizio Costabile ; ^{maurizio.costabile@unisa.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：IDO ; Indoleamine 2 ; 3-dioxygenase ; Kyn ; Kynurenine ; IFNγ ; Interferon-γ ; PKA ; Protein kinase A ; DP1 ; Prostanoid DP receptor ; CRTH2 ; Chemoattractant receptor homologous molecule expressed on Th2 cells

刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids

出版年：2016

8.A Trial of an Oral CRTH2 Antagonist in Antihistamine-Refractory Chronic Spontaneous Urticaria

作者：Dr. Eric Oliver ; MD¹ ; Ms. Kristin Chichester ; MS¹ ; Ms. Kelly Devine ; RN¹ ; Ms. Patricia M. Sterba ; MS¹ ; Dr. Craig Wegner ; PhD² ; Dr. Becky Vonakis ; PhD FAAAAI¹ ; Dr. Sarbjit S. Saini ; MD FAAAAI¹

刊名：Journal of Allergy and Clinical Immunology

出版年：2016

9.Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3

作者：Hidekazu Saito^a ; Kohei Honda^a ; ^{kohei@med.akita-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Chikara Asaka^a ; Shigeharu Ueki^b ; Kazuo Ishikawa^a

关键词：Asthma ; Chronic sinusitis ; Eosinophils ; Eotaxin ; Nasal polyps

刊名：Allergology International

出版年：2016

10.Identification of leads through in silico approaches utilizing benzylthio-1H-benzo[d]imidazol-1-yl acetic acid derivatives: A potent CRTh2 antagonist

作者：Sathya Babu^a ; Seema A. Kulkarni^b ; Honglae Sohn^c ; ^{hsohn@chosun.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Thirumurthy Madhavan^a ; ^{thirumurthy.m@ktr.srmuniv.ac.in" class="auth_mail" title="E-mail the corresponding author} ; ^{thiru.murthyunom@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：CRTh2 ; Pharmacophore ; Virtual screening ; Molecular docking ; CoMFA

刊名：Journal of Molecular Structure

出版年：2015

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