搜索页_Cyclin dependent kinase (cdk) inhibitors

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在“Elsevier电子期刊”中，命中：692条，耗时：0.0639729 秒

在所有数据库中总计命中：979条

1.A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27

作者：Ying Huang^a ; ¹ ; Renyi Wu^a ; ¹ ; Zheng-Yuan Su^a ; ^c ; Yue Guo^a ; Xi Zheng^b ; Chung S. Yang^b ; Ah-Ng Kong^a ; ^{KongT@pharmacy.rutgers.edu}

关键词：T3 ; tocotrienol ; T ; tocopherol ; HDAC ; histone deacetylase ; HAT ; histone acetyltransferase ; CDK ; cyclin-dependent kinase

刊名：The Journal of Nutritional Biochemistry

出版年：2017

2.Agastache rugosa Kuntze extract, containing the active component rosmarinic acid, prevents atherosclerosis through up-regulation of the cyclin-dependent kinase inhibitors p21^WAF1/CIP1 and p27^KIP1

作者：Jung-Jin Lee^a ; ^{mhjj3998@kiom.re.kr} ; Ji-Hye Lee^a ; ^{ideal0723@kiom.re.kr} ; Min Jung Gu^a ; ^{guminjung@kiom.re.kr} ; Joo-Hui Han^b ; ^{han5621@cnu.ac.kr} ; Won-Kyung Cho^a ; ^{wkcho@kiom.re.kr} ; Jin Yeul Ma^a ; ^{jyma@kiom.re.kr}

关键词：AKT ; phosphatidylinositol 3-kinase-linked protein kinase ; A.rugose ; Agastacherugosa Kuntze ; BrdU ; bromodeoxyuridine ; CA ; caffeic acid ; CCK-8 ; cell counting Kit-8 ; CDK ; cyclin-dependent kinase ; CKI ; cyclin-dependent kinase inhibitor ; DAD ; diode array UV/VIS detector ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; ERK ; extracellular signal regulated kinase 1/2 ; FBS ; fetal bovine serum ; HPLC ; high-performance liquid chromatographic ; JNK ; c-Jun N-terminal kinase ; PBS ; phosphate-buffered salin

刊名：Journal of Functional Foods

出版年：2017

3.Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

作者：Michaela Hylsová ; ^a ; ¹ ; Benoit Carbain^a ; ^f ; ¹ ; Jindřich Fanfrlí ; k^b ; ¹ ; Lenka Musilová ; ^a ; Susanta Haldar^b ; ^c ; Cemal Kö ; prü ; lü ; oğlu^b ; ^c ; Haresh Ajani^b ; ^c ; Pathik S. Brahmkshatriya^b ; Radek Jorda^d ; Vladimí ; r Kry&scaron ; tof^d ; Pavel Hobza^b ; ^c ; Aude Echalier^e ; ² ; Kamil Paruch^a ; ^f ; ^{paruch@chemi.muni.cz} ; Martin Lep&scaron ; í ; k^b ; ^{lepsik@uochb.cas.cz}

关键词：Cyclin-dependent kinase 2 ; ATP-competitive type I inhibitors ; Pyrazolo[1 ; 5-a]pyrimidine ; Quantum mechanical scoring ; Protein-ligand binding ; Molecular dynamics ; Water thermodynamics ; X-ray crystal structure

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies

作者：Erik S. Knudsen¹ ; ² ; ^{eknudsen@email.arizona.edu} ; Agnieszka K. Witkiewicz¹ ; ² ; ³ ; ^{awitki@email.arizona.edu}

关键词：cell cycle ; cyclin D1 ; E2F ; RB ; breast cancer.

刊名：Trends in Cancer

出版年：2017

5.A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore

作者：Yihui Shi ; Jaehyeon Park ; Chandraiah Lagisetti ; Wei Zhou ; Lidia C. Sambucetti ; Thomas R. Webb ; ^{thomas.webb@sri.com}

关键词：CLK ; cdc2-like kinase ; MDM2 ; mouse double minute 2 homolog ; Luc ; luciferase ; TEA ; triethylamine ; DIPEA ; diisopropylethylamine ; EtOAc ; ethyl acetate

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain

作者：Ryosuke Takaya^a ; Jun Nagai^a ; ^b ; Wenfui Piao^a ; Emi Niisato^a ; Takeru Nakabayashi^a ; Yuki Yamazaki^a ; Fumio Nakamura^c ; Naoya Yamashita^c ; Papachan Kolattukudy^d ; Yoshio Goshima^c ; Toshio Ohshima^a ; ^{ohshima@waseda.jp}

关键词：ANOVA ; analysis of variance ; CA1 ; cornu ammonis 1 ; Cdk ; cyclin dependent kinase ; CNS ; central nervous system ; CRMP ; collapsin response mediator protein ; CRMP2ki/ki ; CRMP2 knock-in ; EDTA ; ethylenediaminetetraacetic acid ; GFP ; green fluorescent protein ; GSK ; glycogen synthase kinase ; MAIs ; myelin-associated inhibitors ; O/N ; overnight ; PFA ; paraformaldehyde ; RT ; room temperature ; Sema3A ; semaphorin3A ; WT ; wild-type

刊名：Brain Research

出版年：2017

7.Caloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials

作者：Gelina S. Kopeina^a ; Vyacheslav V. Senichkin^a ; Boris Zhivotovsky^a ; ^b ; ^{Boris.Zhivotovsky@ki.se}

关键词：Acetyl-CoA/CoA ; acetyl-coenzyme A/Coenzyme A ratio ; AMPK ; AMP-dependent kinase ; APL ; autophagolysosome ; ATG ; autophagy-related gene ; ATP/ADP ; adenosine triphosphate/adenosine diphosphate ratio ; CDK ; cyclin-dependent kinase ; CR ; caloric restriction ; CRM ; caloric restriction mimetics ; DDA ; DNA-damaging agent ; DSR ; differential stress resistance ; EMA ; the European Medicines Agency ; ER ; endoplasmic reticulum ; Erk 1/2 ; extracellular signal&ndash ; regulated kinases 1/2 ; FDA ; Food and Drug Administratio

刊名：Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

出版年：2017

8.The effect of desolvation on the binding of inhibitors to HIV-1 protease and cyclin-dependent kinases: Causes of resistance

作者：Clifford W. Fong ^{cwfong@internode.on.net" class="auth_mail" title="E-mail the corresponding author}

关键词：HIV ; human immunodeficiency virus ; CDK ; cyclin-dependent kinases ; MDR ; multi-drug resistant ; ΔGdesolvation ; free energy of water desolvation ; ΔGlipophilicity ; free energy of lipophilicity or hydrophobicity ; ΔGdesolv ; CDS ; free energy of water desolvation of the cavitation dispersion solvent structure (CDS) ; ΔGlipo ; CDS ; free energy of lipophilicity or hydrophobicity for the CDS ; DM ; dipole moment ; EA ; electron affinity ; IE ; ionization energy ; ε ; dielectric constant ; R2 ; multiple correlation coeffi

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases

作者：Ladislava Vymětalová ; ^a ; Libor Havlí ; ček^b ; Antoní ; n &Scaron ; turc^a ; Zuzana Skrá ; &scaron ; ková ; ^a ; Radek Jorda^a ; Tomá ; &scaron ; Pospí ; &scaron ; il^a ; Miroslav Strnad^a ; Vladimí ; r Kry&scaron ; tof^a ; ^{vladimir.krystof@upol.cz" class="auth_mail" title="E-mail the corresponding author}

关键词：Cyclin-dependent kinase ; Inhibitor ; Selectivity ; Bioisostere

刊名：European Journal of Medicinal Chemistry

出版年：2016

10.Cyclin-Dependent Kinase 4/6 Inhibitors for the Treatment of Breast Cancer: A Review of Preclinical and Clinical Data

作者：Neelima Vidula ; Hope S. Rugo ; ^{Hope.Rugo@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Abemaciclib ; CDK 4/6 inhibitors ; Hormone receptor-positive breast cancer ; Palbociclib ; Ribociclib

刊名：Clinical Breast Cancer

出版年：2016

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