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在“Elsevier电子期刊”中，命中：14,501条，耗时：0.1059751 秒

在所有数据库中总计命中：24,369条

1.Drug-protein binding of Danhong injection and the potential influence of drug combination with aspirin: Insight by ultrafiltration LC-MS and molecular modeling

作者：Junfeng Zhu ; Xiaojiao Yi ; Peng Huang ; Shuqing Chen ; Yongjiang Wu ; ^{yjwu@zju.edu.cn}

关键词：Drug-protein binding ; Danhong injection ; Aspirin ; Human serum albumin ; Ultrafiltration LC&ndash ; MS ; Molecular modeling

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2017

2.Alchemical determination of drug-receptor binding free energy: Where we stand and where we could move to

作者：Piero Procacci ^{procacci@unifi.it}

关键词：Binding free energy ; Alchemical simulations ; Solute tempering ; Hamiltonian Replica Exchange ; Jarzynski theorem ; Crooks theorem ; Drug-receptor ; Molecular dynamics ; Nonequilibrium process

刊名：Journal of Molecular Graphics and Modelling

出版年：2017

3.Cocaine self-administration, extinction training and drug-induced relapse change metabotropic glutamate mGlu5 receptors expression: Evidence from radioligand binding and immunohistochemistry assays

作者：Lucyna Pomierny-Chamiolo^a ; ^{lpomiern@cm-uj.krakow.pl} ; Joanna Miszkiel^b ; Malgorzata Frankowska^b ; Beata Bystrowska^a ; Malgorzata Filip^b

关键词：Cocaine self-administration ; Extinction training ; Drug-induced relapse ; MGlu5 receptor binding ; MGlu5 receptor immunohistochemistry

刊名：Brain Research

出版年：2017

4.New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs

作者：Simon J.A. van Kuijk^a ; ¹ ; ^{s.vankuijk@maastrichtuniversity.nl} ; Nanda Kumar Parvathaneni^a ; ^b ; ¹ ; ^{nanda-kumar.parvathaneni@etu.umontpellier.fr} ; Raymon Niemans^a ; ¹ ; Marike W. van Gisbergen^a ; ¹ ; Fabrizio Carta^c ; Daniela Vullo^d ; Silvia Pastorekova^e ; Ala Yaromina^a ; Claudiu T. Supuran^c ; Ludwig J. Dubois^a ; ² ; Jean-Yves Winum^b ; ² ; Philippe Lambin^a ; ²

关键词：Tumor ; Hypoxia ; Carbonic anhydrase IX ; Dual-target drugs ; CAIX inhibitors ; Cytotoxic drugs

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

作者：Rituparna Mittra^a ; Megan Pavy^a ; Nanditha Subramanian^b ; Anthony M. George^c ; Megan L. O'Mara^b ; Ian D. Kerr^d ; Richard Callaghan^a ; ^{richard.callaghan@anu.edu.au}

关键词：Vinblastine sulphate (PubMed CID ; 5388983) ; Nicardipine hydrochloride (PubMed CID ; 41114) ; Paclitaxel (PubMed CID ; 36314) ; Rhodamine123 (PubMed CID ; 9929799) ; Adenosine triphosphate (PubMed CID ; 5957)

刊名：Biochemical Pharmacology

出版年：2017

6.Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B

作者：Marko Jukič^a ; Janez Ila&scaron ; ^a ; Matjaž Brvar^b ; Danijel Kikelj^a ; Jožko Cesar^a ; Marko Anderluh^a ; ^{marko.anderluh@ffa.uni-lj.si}

关键词：Antibiotics ; Antibacterials ; Inhibitor ; DNA gyrase B ; ATP binding site ; Pyrrole-2-carboxamides ; Structure-based drug design ; Ligand-based drug design

刊名：European Journal of Medicinal Chemistry

出版年：2017

7.Binding of small molecules at interface of protein-protein complex - A newer approach to rational drug design

作者：A.B. Gurung^a ; A. Bhattacharjee^a ; M. Ajmal Ali^b ; ^{alimohammad@ksu.edu.sa} ; F. Al-Hemaid^b ; Joongku Lee^c

关键词：Hot spots ; Protein interfaces ; Druggability ; Orthosteric inhibitor ; Allosteric inhibitor ; Interfacial binding inhibitor

刊名：Saudi Journal of Biological Sciences

出版年：2017

8.Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa

作者：Yuanyuan Chen^a ; Matthew J. Brooks^b ; Linn Gieser^b ; Anand Swaroop^b ; Krzysztof Palczewski^a ; ^{kxp65@case.edu}

关键词：ad ; autosomal dominant ; BP ; biological process ; CHOP ; C/EBP homologous protein ; CRE ; the cAMP-responsive element ; CREB ; the cAMP-responsive element-binding protein ; CREM ; the cAMP-responsive element modulator ; ATF-1 ; activating transcription factor-1 ; DAVID ; the database for annotation visualization and integrated discovery ; DE ; differential expression ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; ER ; endoplasmic reticulum ; ERAD ; ER-associated protein degradation ; FDA ; Food and Drug Adm

刊名：Pharmacological Research

出版年：2017

9.A surface-grafted ligand functionalization strategy for coordinate binding of doxorubicin at surface of PEGylated mesoporous silica nanoparticles: Toward pH-responsive drug delivery

作者：Qing Zhang ; ^{zhtsing101@sina.com} ; Haoyu Zhao ; Dong Li ; Liping Liu ; Shuhu Du ; ^{shuhudu@njmu.edu.cn}

关键词：Mesoporous silica nanoparticles ; pH-Response ; Coordinate bonds ; Targeting ; Doxorubicin

刊名：Colloids and Surfaces B: Biointerfaces

出版年：2017

10.Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRα from Drugbank database

作者：Dan Xu¹ ; ^a ; Lijun Cai¹ ; ^a ; Shangjie Guo^a ; Lei Xie^a ; Meimei Yin^a ; Ziwen Chen^a ; Hu Zhou^a ; Ying Su^a ; ^b ; Zhiping Zeng^a ; ^{zengzhiping@xmu.edu.cn} ; Xiaokun Zhang^a ; ^b ; ^{xkzhang@xmu.edu.cn}

关键词：RXRα ; Old drug ; Agonist ; Antagonist ; Virtual screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

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