搜索页_Early afterdepolarization (EAD)

常用资源

电子图书

期刊论文

学位会议

外文资源

Elsevier电子期刊(79)

在“Elsevier电子期刊”中，命中：79条，耗时：0.0219884 秒

在所有数据库中总计命中：97条

1.Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates

作者：Taeko Kubo ; DVM ; PhD^a ; ^b ; ^c ; ^{taeko-kubo@ds-pharma.co.jp} ; ^{taekok2016@gmail.com} ; Takashi Ashihara ; MD ; PhD^b ; Tadashi Tsubouchi ; PhD^a ; Minoru Horie ; MD ; PhD^b

关键词：AP ; action potential ; APD ; action potential duration ; APD30 ; APD at 30% repolarization ; APD90 ; APD at 90% repolarization ; APD30&ndash ; 90 ; APD90&ndash ; APD30 ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CiPA ; Comprehensive in vitro Proarrhythmia Assay ; CV ; conduction velocity ; EAD ; early afterdepolarization ; ECG ; electrocardiogram ; Endo ; endocardial ; Epi ; epicardial ; FH ; failing heart ; ICH ; International Conference of Harmonization ; IQ-CSRC ; Innovation and Quality in Pharmaceutical Deve

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

作者：Stefano Morotti^a ; Andrew D. McCulloch^b ; Donald M. Bers^a ; Andrew G. Edwards^c ; ^d ; Eleonora Grandi^a ; ^{ele.grandi@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ACh ; acetylcholine ; AF ; atrial fibrillation ; AP ; action potential ; APD ; action potential duration ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CaMKII ; Ca2 ; +/calmodulin-dependent protein kinase II ; DAD ; delayed afterdepolarization ; EAD ; early afterdepolarization ; Em ; membrane potential ; ICa ; L-type Ca2 ; + current ; INa ; Na+ current ; IKr ; delayed rectifier K+ current ; INCX ; Na+/Ca2 ; + exchanger current ; ISO ; isoproterenol ; NCX ; Na+/Ca2 ; + exchanger ; pAF ; paroxysmal atria

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

3.Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca^{2 +} release events in a rodent model of early stage diabetes: The arrhythmogenic substrate

作者：Leandro Sommese^a ; Carlos A. Valverde^a ; Paula Blanco^b ; Marí ; a Cecilia Castro^c ; Omar Velez Rueda^a ; Marcia Kaetzel^d ; John Dedman^d ; Mark E. Anderson^e ; Alicia Mattiazzi^a ; Julieta Palomeque^a ; ^{julip@med.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; AV ; atrioventricular ; Ca2 ; +i ; intracellular calcium ; CaiT ; intracellular calcium transient ; CaMKII ; Ca2 ; + calmodulin dependent protein kinase ; CaSp ; calcium sparks ; CaW ; calcium waves ; DAD ; delay afterdepolarizations ; EAD ; early afterdepolarizations ; ECG ; electrocardiogram ; LV ; left ventricle ; RyR2 ; ryanodine receptor 2 ; PLN ; phospholamban ; NCX ; sodium&ndash ; Ca2 ; + exchanger ; ROS ; reactive oxygen species ; SR ; sarcoplasmic reticulum ; T2DM ; type 2 diabetes me

刊名：International Journal of Cardiology

出版年：2016

4.A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials

作者：Kirstine Calloe^a ; ^{kirstinec@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; José ; M. Di Diego^b ; Rie Schultz Hansen^c ; Shea A. Nagle^b ; Jacqueline A. Treat^b ; Jonathan M. Cordeiro^b ; ^{jcordeiro@mmrl.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AP ; action potential ; APD ; action potential duration ; EAD ; early afterdepolarization ; HF ; heart failure

刊名：Biochemical Pharmacology

出版年：2016

5.Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

作者：Sara Dutta^a ; ¹ ; Ana Mincholé ; ^a ; ¹ ; Ernesto Zacur^b ; T. Alexander Quinn^c ; Peter Taggart^d ; Blanca Rodriguez^a ; ^{blanca.rodriguez@cs.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Ischemic heart disease ; Computer-based model ; Ventricular arrhythmia ; Potassium channels ; Repolarization

刊名：Progress in Biophysics and Molecular Biology

出版年：2016

6.Role of the dysfunctional ryanodine receptor - Na⁺-Ca²⁺exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies?

作者：Ká ; roly Acsai^a ; Balá ; zs Ö ; rdö ; g^b ; Andrá ; s Varró ; ^a ; ^b ; Pé ; ter P. Ná ; ná ; si^c ; ^d ; ^{nanasi.peter@med.unideb.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：RyR2 ; Ryanodine receptor Ca2+-Release channel type 2 ; NCX1 ; Na+-Ca2+-exchanger type 1 ; SR ; Sarco(endo)plasmic reticulum ; TRPC6 ; Transient receptor potential-like channel 6 ; NKA ; Na+-K+-ATP-ase ; ATP ; Adenosine-triphosphate ; CamKII ; Ca2+/calmodulin-dependent protein kinase II ; ICa ; I-Type Ca2+-current ; EAD ; Early afterdepolarization ; DAD ; Delayed afterdepolarization ; TdP ; Torsades de pointes tachycardia

刊名：European Journal of Pharmacology

出版年：2016

7.The link between abnormal calcium handling and electrical instability in acquired long QT syndrome - Does calcium precipitate arrhythmic storms?

作者：Jan Němec¹ ; Jong J. Kim¹ ; ² ; Guy Salama ; ^{gsalama@pitt.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Action potential ; AP ; AP duration ; APD ; Triggered activity ; TA ; Long QT syndrome ; LQTS ; Long QT type 2 ; LQT2 ; Systolic secondary Ca2+ release ; SSCR ; Early afterdepolarization ; EAD ; Delayed afterdepolarization ; DAD ; Simultaneous mapping of voltage and intracellular free Ca2+ ; Subcellular voltage and Ca2+ imaging

刊名：Progress in Biophysics and Molecular Biology

出版年：2016

8.Safety pharmacology studies using EFP and impedance

作者：Alison Obergrussberger ; ^{ali@nanion.de" class="auth_mail" title="E-mail the corresponding author} ; Krisztina Juhasz ; Ulrich Thomas ; Sonja Stö ; lzle-Feix ; Nadine Becker ; Leo Dö ; rr ; Matthias Beckler ; Corina Bot ; Michael George ; Niels Fertig

关键词：CardioExcyte 96 ; Dofetilide ; E4031 ; EAD-like ; Extracellular field potential ; Impedance ; Isoproterenol ; Nifedipine ; Pentamidine ; Safety pharmacology

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

9.Low proarrhythmic potential of citalopram and escitalopram in contrast to haloperidol in an experimental whole-heart model

作者：Gerrit Frommeyer^a ; ^{gerrit.frommeyer@ukmuenster.de" class="auth_mail" title="E-mail the corresponding author} ; Benedict Brü ; cher^a ; Henning von der Ahe^a ; Sven Kaese^a ; Dirk G. Dechering^a ; Simon Kochhä ; user^a ; Harilaos Bogossian^b ; Peter Milberg^a ; Lars Eckardt^a

关键词：Citalopram ; Escitalopram ; Haloperidol ; Dispersion of repolarization ; Proarrhythmia ; Sudden cardiac death

刊名：European Journal of Pharmacology

出版年：2016

10.Antiarrhythmic effects and potential mechanism of WenXin KeLi in cardiac Purkinje cells

作者：Jian-Wen Hou ; MD^* ; Wei Li ; MD^* ; Kai Guo ; MD^* ; Xiao-Meng Chen ; MD^* ; Yi-He Chen ; MD^* ; Chang-Yi Li ; MD^* ; Bu-Chang Zhao ; MD^&dagger ; ; Jing Zhao ; MD^&dagger ; ; Hong Wang ; PhD^* ; Yue-Peng Wang ; MD ; PhD^* ; Yi-Gang Li ; MD ; FHRS^* ; ^{drliyigang@outlook.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Antiarrhythmic drugs ; Cardiac Purkinje cells ; Electrophysiology ; WenXin KeLi ; Late sodium current

刊名：Heart Rhythm

出版年：2016

按检索点细分(79)

题名(1)

关键词(21)

文摘(60)

按出版年细分(79)

2027年及以后(3)

2017年(1)

2016年(11)

2015年(1)

2013年(5)

2012年(6)

2011年(3)

2010年(5)

2009年(1)

2008年(2)

2007年(2)

2006年(2)

2005年(3)

2004年(8)

2003年(2)

2002年(2)

2001年(2)

2000年(1)

2000年及以前(19)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700