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在“Elsevier电子期刊”中，命中：442条，耗时：0.0159918 秒

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1.Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

作者：Chi Zhang^a ; ^c ; ¹ ; Xin Wang^b ; ^d ; ¹ ; Hongchun Liu^b ; Minmin Zhang^b ; Meiyu Geng^b ; Liping Sun^a ; ^{chslp@cpu.edu.cn} ; Aijun Shen^b ; ^{shenaj@simm.ac.cn} ; Ao Zhang^c ; ^{aozhang@simm.ac.cn}

关键词：Diarylisoxazole ; Resorcinol ; Amino acid ; Hsp90 inhibitor ; Antiproliferative effect

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Design, synthesis and biological evaluation of 7-(aryl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline derivatives as potential Hsp90 inhibitors and anticancer agents

作者：Sina Omid Malayeri^a ; ^b ; Khalil Abnous^c ; Atefeh Arab^d ; Maryam Akaberi^e ; Soghra Mehri^c ; Afshin Zarghi^f ; Razieh Ghodsi^a ; ^b ; ^{ghodsir@mums.ac.ir}

关键词：Quinolines ; Heat Shock Protein 90 ; Anti-cancer activity ; Her2 ; Molecular docking ; Hsp90 inhibitor

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Virtual screening and biophysical studies lead to HSP90 inhibitors

作者：Renjie Huang ; Daniel M. Ayine-Tora ; M. Nasri Muhammad Rosdi ; Yu Li ; Jó ; hannes Reynisson ; ^{j.reynisson@auckland.ac.nz} ; Ivanhoe K.H. Leung ; ^{i.leung@auckland.ac.nz}

关键词：17-AAG ; 17-allylamino-17-demethoxygeldanamycin ; 17-DMAG ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) ; ADP ; adenosine diphosphate ; AMPPCP ; 5&prime ; -adenylylmethylenediphosphonate ; ASP ; Astex statistical potential ; ATP ; adenosine triphosphate ; CS ; ChemScore ; GS ; GoldScore ; HB ; hydrogen bonding ; HSP90 ; heat shock protein 90 ; HSQC ; heteronuclear single quantum correlation ; KD ; binding affinity ; ND ; N-domain ; NMR ; nuclear magnetic resonance ; NOE ; nuclear Overhauser effect ; Tm ; pro

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation

作者：Stefan Tukaj¹ ; ² ; ⁵ ; Katja Bieber³ ; ⁵ ; Konrad Kleszczyński¹ ; Mareike Witte¹ ; Rebecca Cames¹ ; Kathrin Kalies⁴ ; Detlef Zillikens¹ ; ³ ; Ralf J. Ludwig¹ ; ³ ; Tobias W. Fischer¹ ; Michael Kasperkiewicz¹ ; ^{Michael.Kasperkiewicz@uksh.de}

关键词：17AAG ; 17-allylamino-demethoxygeldanamycin ; COL7 ; type VII collagen ; EBA ; epidermolysis bullosa acquisita ; MMP ; matrix metalloproteinase ; PBS ; phosphate buffered saline ; qRT-PCR ; quantitative real-time reverse transcriptase-PCR ; RT ; room temperature

刊名：Journal of Investigative Dermatology

出版年：2017

5.Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4′fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells

作者：Zuzana Solá ; rová ; ^a ; Martin Kello^a ; Lenka Varinská ; ^a ; Mariana Budovská ; ^b ; Peter Solá ; r^c ; ^{peter.solar@upjs.sk}

关键词：thiazine[6 ; 5-b]indole ; 2-(4&prime ; fluoro-phenylamino)-4H-1 ; 3-thiazine[6 ; 5-b]indole ; Hsp ; heat shock protein ; 17-DMAG ; 17-dimethylaminoethylamino-17-demethoxygeldanamycin ; 17-AAG ; 17-(allylamino)-17-demethoxygeldanamycin ; A2780 ; human ovarian adenocarcinoma cell line ; A2780cis ; human ovarian adenocarcinoma cell line resistant to cisplatin ; PARP ; poly (ADP-ribose) polymerase ; MMP ; mitochondrial membrane potential ; An ; annexin ; PI ; propidium iodide

刊名：Biomedicine & Pharmacotherapy

出版年：2017

6.Proteomic level changes associated with S3I201 treated U87 glioma cells

作者：Rekha Jain ; Apurva Atak ; Avani Yeola ; Sanjeeva Srivastava ; ^{sanjeeva@iitb.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Two-dimensional gel electrophoresis ; Glioblastoma ; iTRAQ ; Mass spectrometry ; STAT3 inhibitor ; S3I201

刊名：Journal of Proteomics

出版年：2017

7.Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy

作者：Dae Hwan Shin ; Glen S. Kwon ; ^{gskwon@pharmacy.wisc.edu}

关键词：Epothilone B ; Polymeric micelle ; Non-small cell lung cancer ; Drug combination ; Multiple drug solubilization

刊名：International Journal of Pharmaceutics

出版年：2017

8.The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib

作者：Kang-Seo Park^a ; Bora Oh^b ; Mi-Hee Lee^b ; Ky-Youb Nam^a ; Hae Ran Jin^a ; Hannah Yang^b ; ^c ; Junyoung Choi^a ; Sang-We Kim^b ; Dae Ho Lee^a ; ^b ; ^{leedaeho@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：NSCLC ; HSP90 inhibitor ; MEK inhibitor ; KRAS mutation ; Combination therapy

刊名：Cancer Letters

出版年：2016

9.Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation

作者：Ankit K. Rochani ; Sivakumar Balasubramanian ; Aswathy Ravindran Girija ; Sreejith Raveendran ; Ankita Borah ; Yutaka Nagaoka ; Yoshikata Nakajima ; Toru Maekawa ; D. Sakthi Kumar ; ^{sakthi@toyo.jp" class="auth_mail" title="E-mail the corresponding author} ; ^{drsakthi@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Nanotechnology ; Cancer chemotherapy ; Hsp90 inhibitor ; Nano formulation ; 17AAG

刊名：International Journal of Pharmaceutics

出版年：2016

10.Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity

作者：Xiaoli Xu^a ; ^b ; Yue Wu^a ; ^b ; Mingyang Hu^a ; ^b ; Xiang Li^a ; ^b ; Congying Gu^a ; ^c ; Qidong You^a ; ^b ; ^{youqd@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaojin Zhang^a ; ^c ; ^{zxj@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Caged xanthones ; Hsp90 inhibitor ; Antitumor ; Anti-angiogenesis ; Gambogic acid

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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