搜索页_Human+5-lipoxygenase

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1.Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase

作者：Antonella Peduto^a ; ^f ; ¹ ; Maria Scuotto^a ; ¹ ; Verena Krauth^b ; ¹ ; Fiorentina Roviezzo^c ; Antonietta Rossi^c ; Veronika Temml^d ; Veronica Esposito^c ; Hermann Stuppner^d ; Daniela Schuster^e ; Bruno D'Agostino^a ; Chiara Schiraldi^a ; Mario de Rosa^a ; Oliver Werz^b ; ^{oliver.werz@uni-jena.de} ; Rosanna Filosa^a ; ^f ; ^{rosanna.filosa@unina2.it}

关键词：5-Lipoxygenase ; Quinones

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

作者：Simon B.M. Kretschmer^a ; Stefano Woltersdorf^a ; Dominik Vogt^a ; Felix F. Lillich^a ; Michael Rü ; hl^a ; Michael Karas^a ; Isabelle V. Maucher^a ; Jessica Roos^a ; Ann-Kathrin Hä ; fner^a ; Astrid Kaiser^a ; Mario Wurglics^a ; Manfred Schubert-Zsilavecz^a ; Carlo Angioni^b ; Gerd Geisslinger^b ; Holger Stark^c ; Dieter Steinhilber^a ; Bettina Hofmann^a ; ^{hofmann@pharmchem.uni-frankfurt.de}

关键词：5-Lipoxygenase ; Aminothiazole ; Leukotrienes ; Inflammation ; ST-1853 ; ST-1906

刊名：Biochemical Pharmacology

出版年：2017

3.Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

作者：Isabelle V. Maucher^a ; Michael Rü ; hl^a ; Simon B.M. Kretschmer^a ; Bettina Hofmann^a ; Benjamin Kü ; hn^a ; Jasmin Fettel^a ; Anja Vogel^a ; ^b ; Karsten T. Flü ; gel^a ; Georg Manolikakes^c ; Nadine Hellmuth^a ; Ann-Kathrin Hä ; fner^a ; Vahid Golghalyani^a ; Ann-Katrin Ball^a ; Matthias Piesche^d ; ^g ; Carmela Matrone^d ; Gerd Geisslinger^b ; ^e ; Michael J. Parnham^b ; Michael Karas^a ; Dieter Steinhilber^a ; Jessica Roos^a ; ¹ ; ^{roos@pharmchem.uni-frankfurt.de} ; Thorsten J. Maier^d ; ^f ; ¹ ; ^{maier@biomed.au.dk}

关键词：AA ; arachidonic acid ; methyl-BQ ; 2 ; 5-dimethyl-1 ; 4-benzoquinone ; CDDO ; CDDO-methylester ; methoxy-BQ ; 2 ; 3-dimethoxy-5-methyl-p-benzoquinone ; methoxy-NS ; 3-methoxy-β-nitrostyrene ; DMF ; dimethyl fumarate ; GSH ; glutathione ; OH-BQ ; 2 ; 5-dihydroxy-1 ; 4-benzoquinone ; HPLC ; high-performance liquid chromatography ; H(P)ETE ; hydro (peroxy-) eicosatetraenoic acid ; LT ; leukotrienes ; MS ; mass spectrometry ; NAC ; N-acetylcysteine ; NAPQI ; N-acetyl-p-benzoquinone imine ; NEM ; N-ethylmaleimide ; NFA ; nitro-fatty acid

刊名：Biochemical Pharmacology

出版年：2017

4.Corrigendum to “The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog” [Biochim. Biophys. Acta 1861/1, (2016) 1-11]

作者：Susan Adel ; Dagmar Heydeck ; Hartmut Kuhn ; ^{hartmut.kuehn@charite.de} ; Christoph Ufer

刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

出版年：2017

5.QSAR studies on antimony(III) halide complexes with N-substituted thiourea derivatives

作者：I.I. Ozturk^a ; ^{iiozturk@nku.edu.tr} ; S. Yarar^a ; C.N. Banti^b ; ^{cbanti@cc.uoi.gr} ; N. Kourkoumelis^c ; ^{nkourkou@uoi.gr} ; M.P. Chrysouli^b ; M. Manoli^d ; A.J. Tasiopoulos^d ; S.K. Hadjikakou^b ; ^{shadjika@uoi.gr}

关键词：Biological Inorganic Chemistry ; Antimony(III) halide ; Thiourea ; Cytotoxicity ; QSAR

刊名：Polyhedron

出版年：2017

6.A potent and selective inhibitor targeting human and murine 12/15-LOX

作者：Michelle M. Armstrong^a ; Cody J. Freedman^a ; Joo Eun Jung^b ; Yi Zheng^b ; Chakrapani Kalyanaraman^c ; Matthew P. Jacobson^c ; ^&dagger ; ; Anton Simeonov^d ; David J. Maloney^d ; Klaus van Leyen^b ; Ajit Jadhav^d ; Theodore R. Holman^a ; ^{holman@ucsc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：LOX ; lipoxygenase ; hLOX ; human lipoxygenase ; h15-LOX-2 ; human epithelial 15-lipoxygenase-2 ; h12/15-LOX ; h15-LOX-1 ; human reticulocyte 15-lipoxygenase-1 ; h12-LOX ; human platelet 12-lipoxygenase ; s15-LOX-1 ; soybean 15-lipoxygenase-1 ; h5-LOX ; human leukocyte 5-lipoxygenase ; AA ; arachidonic acid ; LA ; linoleic acid ; 12-HETE ; 12-hydroxy-58 ; 10 ; 14-eicosatetraenoic acid ; 12-HpETE ; 12-hydroperoxyeicosatetraenoic acid ; 15-HpETE ; 15-hydroperoxyeicosatetraenoic acid ; 13-HpODE ; 13-(S)-hydroperoxyoctadecadien

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency

作者：Michelle Armstrong^a ; Christopher van Hoorebeke^a ; Thomas Horn^a ; ^&dagger ; ; Joshua Deschamps^a ; J. Cody Freedman^a ; Chakrapani Kalyanaraman^b ; Matthew P. Jacobson^b ; Theodore Holman^a ; ^{holman@ucsc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：LOX ; lipoxygenase ; h15-LOX-1 ; human reticulocyte 15-lipoxygenase-1 ; tPA ; tissue plasminogen activator ; FDA ; Food and Drug Administration ; s15-LOX-1 ; soybean 15-lipoxygenase-1 ; r15-LOX ; rabbit reticulocyte 15-LOX ; AA ; arachidonic acid ; 12-HpETE ; 12-hydroperoxyeicosatetraenoic acid ; LA ; linoleic acid ; 9R-HpODE ; 9-(R)-hydroperoxyoctadecadienoic acid ; 13-HpODE ; 13-(S)-hydroperoxyoctadecadienoic acid ; 15-HpETE ; 15-hydroperoxyeicosatetraenoic acid ; ICP-MS ; inductively coupled plasma mass spectrometer

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog

作者：Susan Adel ; Dagmar Heydeck ; Hartmut Kuhn ; ^{hartmut.kuehn@charite.de" class="auth_mail" title="E-mail the corresponding author} ; Christoph Ufer

关键词：LOX ; lipoxygenase ; 5S-H(p)ETE ; 5S-hydro(per)oxy- 6E ; 8Z ; 11Z-14Z-eicosatetraenoic acid ; 12S-H(p)ETE ; 12S-hydro(pero)xy-5Z ; 8Z ; 10E ; 14Z-eicosatetraenoic acid ; 15S-H(p)ETE ; 15S-hydro(pero)xy-5Z ; 8Z ; 11Z ; 13E-eicosatetraenoic acid ; RP-HPLC ; reversed phase high performance liquid chromatography ; SP-HPLC ; straight phase high performance liquid chromatography ; CP-HPLC ; chiral phase high performance liquid chromatography

刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids

出版年：2016

9.Kinetic investigation of human 5-lipoxygenase with arachidonic acid

作者：Monica Mittal^a ; Ramakrishnan B. Kumar^b ; ^c ; Navisraj Balagunaseelan^a ; Mats Hamberg^a ; Caroline Jegerschö ; ld^b ; Olof Rå ; dmark^a ; Jesper Z. Haeggströ ; m^a ; Agnes Rinaldo-Matthis^a ; ^{Agnes.Rinaldo-Matthis@ki.se" class="auth_mail" title="E-mail the corresponding author}

关键词：Lipoxygenase ; Kinetic isotope effect ; Arachidonic acid

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase

作者：Yu Zhou^a ; ^&dagger ; ; Jun Liu^b ; ^&dagger ; ; Mingyue Zheng^a ; ^&dagger ; ; Shuli Zheng^c ; Chunyi Jiang^a ; Xiaomei Zhou^c ; Dong Zhang^a ; Jihui Zhao^a ; Deju Ye^a ; Mingfang Zheng^a ; Hualiang Jiang^a ; Dongxiang Liu^a ; ^{dxl@mail.shcnc.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Jian Cheng^c ; ^{chengjian@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Hong Liu^a ; ^{hliu@mail.shcnc.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：5-Lipoxygenase ; 5-LOX inhibitors ; Pyrazole derivatives ; Leukotrienes-related diseases ; In vivo ; Benzo-fused heterocycle ; Ischemic incults ; Brain inflammation

刊名：Acta Pharmaceutica Sinica B

出版年：2016

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