搜索页_PDF+inhibitor

常用资源

电子图书

期刊论文

学位会议

外文资源

Elsevier电子期刊(113)

在“Elsevier电子期刊”中，命中：113条，耗时：0.0149899 秒

在所有数据库中总计命中：135条

1.New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment

作者：Fengping Lv^a ; Chen Chen^a ; Yang Tang^a ; Jianhai Wei^a ; Tong Zhu^b ; ^{tongzhu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Wenhao Hu^a ; ^{whu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：PDF inhibitor ; Antibacterial drug ; Antibiotics resistance ; MRSA ; Docking study ; Amide bioisosteres

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial

作者：Jeffrey Cui¹ ; Len Philo² ; Phirum Nguyen¹ ; Heather Hofflich³ ; Carolyn Hernandez¹ ; Ricki Bettencourt¹ ; ⁴ ; Lisa Richards¹ ; ⁵ ; Joanie Salotti¹ ; ⁵ ; Archana Bhatt¹ ; Jonathan Hooker⁶ ; William Haufe⁶ ; Catherine Hooker⁶ ; David A. Brenner⁵ ; Claude B. Sirlin⁶ ; Rohit Loomba¹ ; ⁴ ; ⁵ ; ⁷ ; ^{roloomba@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：NAFLD ; non-alcoholic fatty liver disease ; NASH ; non-alcoholic steatohepatitis ; DPP-4 ; dipeptidyl peptidase 4 ; GLP-1 ; glucagon-like peptide-1 ; GIP ; glucose-dependent insulinotropic polypeptide ; HbA1c ; hemoglobin A1c ; SREBP-1c ; sterol regulatory element bind protein-1c ; T2DM ; type 2 diabetes mellitus ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; GGT ; gamma-glutamyl transpeptidase ; MR ; magnetic resonance ; MRI ; magnetic resonance imaging ; MRI-PDFF ; MRI-proton density-fat fraction

刊名：Journal of Hepatology

出版年：2016

3.MicroRNA expression profiling in peritoneal fibrosis

作者：Yoshiyuki Morishita^a ; ^{ymori@jichi.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiromichi Yoshizawa^b ; Minami Watanabe^b ; Reika Imai^b ; Toshimi Imai^b ; Ichiro Hirahara^b ; Tetsu Akimoto^b ; Susumu Ookawara^a ; Shigeaki Muto^b ; Daisuke Nagata^b

关键词：α-SMA ; α-smooth muscle actin ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; FGF ; fibroblast growth factor ; FSP-1 ; fibroblast-specific protein-1 ; MGO ; methylglyoxal ; miRNA ; microRNA ; PD ; peritoneal dialysis ; PDF ; peritoneal dialysis fluid ; PET ; peritoneal equilibrium test ; PF ; peritoneal fibrosis ; PPAR-α ; peroxisome proliferator&ndash ; activated receptor-α ; qRT-PCR ; real-time reverse-transcription polymerase chain reaction ; siRNA ; small interfering RNA ; TGF-β1 ; transforming growth factor-β1 ; VEGF ; va

刊名：Translational Research

出版年：2016

4.Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog

作者：Yun Feng^a ; ^{fjfengyun@sohu.com" class="auth_mail" title="E-mail the corresponding author} ; Dazhang Yang^a ; Hongbo Chen^b ; Wenli Cheng^c ; ^{chengwenli2013@163.com" class="auth_mail" title="E-mail the corresponding author} ; Lixia Wang^b ; Hongxia Sun^b ; ^{hongxsun@iccas.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Yalin Tang^b ; ^{tangyl@iccas.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Bcl-2 gene ; P1 promoter ; G-quadruplex ; Pyridostatin analog ; Transcription

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria

作者：Hee-Yeol Lee ; Kyung-Mi An ; Juyoung Jung ; Je-Min Koo ; Jeong-Geun Kim ; Jong-Min Yoon ; Myong-Jae Lee ; HyeonSoo Jang ; Hong-Sub Lee ; Soobong Park ; Jae-Hoon Kang ; ^{jhkang@ildong.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Peptide deformylase ; Antibacterial ; Gram-positive ; Resistant ; Aminopiperidine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A - an Israeli-German multicenter database study

作者：Gili Kenet^a ; Christoph Bidlingmaier^b ; Nadja Bogdanova^c ; Carmen Escuriola Ettingshausen^d ; Neil Goldenberg^e ; Sven Gutsche^f ; Susan Halimeh^g ; Susanne Holzhauer^h ; Karin Kurnik^b ; Verena Limpergerⁱ ; Ralf Junkerⁱ ; Ulrike Nowak-Gö ; ttl^j ; ^{leagottl@uksh.de" class="auth_mail}

关键词：BU ; Bethesda units ; ED ; exposure days ; F2 ; Factor 2 rs1799963 ; F5 ; Factor 5 rs6025 ; FVIII ; Factor VIII ; F8 ; Factor 8 genotypes ; HA ; hemophilia A ; HRI ; high-titer inhibitor ; HR/CI ; hazard ratio/confidence interval ; ICH ; intracranial hemorrhage ; IFS ; inhibitor-free survival ; IQR ; Interquartile range ; IT ; thrombophilic risk factor ; OR/CI ; Odds ratio/confidence interval ; PUP ; previously untreated patient ; pdFVIII ; plasma-derived factor VIII product ; rFVIII ; recombinant FVIII product

刊名：Thrombosis Research

出版年：April, 2014

7.N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs

作者：Janina Baraniak^&dagger ; ; Aleksandra Pietkiewicz ; Renata Kaczmarek ; Ewa Radzikowska ; Katarzyna Kulik ; Karolina Krolewska ; Marcin Cieslak ; Agnieszka Krakowiak ; Barbara Nawrot ; ^{bnawrot@cbmm.lodz.pl" class="auth_mail}

关键词：Gemcitabine ; Prodrug ; Cytotoxicity ; Anticancer therapy ; DNA polymerase inhibitor

刊名：Bioorganic and Medicinal Chemistry

出版年：1 April, 2014

8.Upregulation of HIF-2伪 induced by sorafenib contributes to the resistance by activating the TGF-伪/EGFR pathway in hepatocellular carcinoma cells

作者：Dali Zhao^a ; Bo Zhai^a ; Changjun He^b ; Gang Tan^a ; Xian Jiang^a ; Shangha Pan^a ; Xuesong Dong^a ; Zheng Wei^a ; Lixin Ma^a ; Haiquan Qiao^a ; Hongchi Jiang^a ; Xueying Sun^a ; ^{kevsun88@hotmail.com" class="auth_mail} ; ^{k.sun@auckland.ac.nz" class="auth_mail}

关键词：ANOVA ; analysis of variance ; ARNT ; aryl hydrocarbon receptor nuclear translocator ; CCK-8 ; Cell Counting Kit-8 ; CHX ; cycloheximide ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; EGFR ; epidermal growth factor receptor ; ERK ; extracellular signal-regulated kinase ; FITC ; fluorescein isothiocyanate ; HCC ; hepatocellular carcinoma ; HIF-1伪 ; hypoxia-inducible factor-1伪 ; HIF-2伪 ; hypoxia-inducible factor-2伪 ; MAPK ; mitogen-activated protein kinase ; PDFR ; platelet-derived growth fact

刊名：Cellular Signalling

出版年：May, 2014

9.Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity

作者：Kunqiang Cui^a ; ¹ ; Weiqiang Lu^a ; ¹ ; Lili Zhu^a ; ¹ ; Xu Shen^a ; ^b ; Jin Huang^a ; ^{huangjin@ecust.edu.cn}

关键词：CAPE ; caffeic acid phenethyl ester ; PDF ; peptide deformylase ; HpPDF ; Helicobacter pylori PDF ; PDIs ; peptide deformylase inhibitors ; FDH ; formate dehydrogenase ; f-MAS ; N-formyl-Met-Ala-Ser

刊名：Biochemical and Biophysical Research Communications

出版年：2013

10.Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity

作者：Jeffrey M. Axten^a ; ^{jeffrey.m.axten@gsk.com} ; Jesú ; s R. Medina^a ; Charles W. Blackledge^a ; Cé ; line Duquenne^a ; Seth W. Grant^a ; Mark A. Bobko^a ; Tony Peng^a ; William H. Miller^a ; Theresa Pinckney^a ; Timothy F. Gallagher^a ; Swarupa Kulkarni^a ; Thomas Lewandowski^a ; Glenn S. Van Aller^a ; Rimma Zonis^a ; Paris Ward^b ; Nino Campobasso^b

关键词：Peptide deformylase ; PDF inhibitor ; Antibacterial ; Antibiotic

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

按检索点细分(113)

题名(3)

关键词(7)

文摘(97)

按出版年细分(113)

2027年及以后(2)

2016年(5)

2013年(2)

2012年(2)

2011年(2)

2010年(2)

2009年(4)

2008年(41)

2007年(1)

2006年(3)

2005年(2)

2004年(5)

2003年(4)

2002年(4)

2001年(2)

2000年(5)

2000年及以前(27)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700