搜索页_Pratik Devasthalea

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Elsevier电子期刊(10)

ACS电子期刊(3)

在“Elsevier电子期刊”中，命中：10条，耗时：小于0.01 秒

在所有数据库中总计命中：13条

1.Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

作者：Pratik Devasthale^a ; ^{pratik.devasthale@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Wang^a ; James Mignone^a ; Kishore Renduchintala^b ; Sridhar Radhakrishnan^b ; Jayanthi Dhanapal^b ; Jagannath Selvaraj^b ; Rajesh Kuppusamy^b ; Mary Ann Pelleymounter^c ; Daniel Longhi^c ; Ning Huang^c ; Neil Flynn^c ; Anthony V. Azzara^c ; Kenneth Rohrbach^c ; James Devenny^c ; Suzanne Rooney^c ; Michael Thomas^c ; Susan Glick^c ; Helen Godonis^c ; Susan Harvey^c ; Mary Jane Cullen^c ; Hongwei Zhang^d ; Christian Caporuscio^d ; Paul Stetsko^c ; Mary Grubb^c ; Christine Huang^c ; Lisa Zhang^c ; Chris Freeden^c ; Brian J. Murphy^c ; Jeffrey A. Robl^a ; William N. Washburn^a ;

关键词：Non-basic MCHR1 antagonists ; Anti-obesity ; Off-rates ; Biliary toxicity ; Metabolite toxicity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

2.7-Oxopyrrolopyridine-derived DPP4 inhibitors¡ªmitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site

作者：Wei ; Wang^a ; ; ; Pratik ; Devasthale^a ; ; ^{pratik.devasthale@bms.com} ; Aiying ; Wang^b ; Tom ; Harrity^b ; Don ; Egan^b ; Nathan ; Morgan^b ; Michael ; Cap^b ; Aberra ; Fura^c ; Herbert E. ; Klei^d ; Kevin ; Kish^d ; Carolyn ; Weigelt^e ; Lucy ; Sun^f ; Paul ; Levesque^f ; Yi-Xin ; Li^g ; Robert ; Zahler^a ; Mark S. ; Kirby^b ; Lawrence G. ; Hamann^a ; ; ^&dagger ;

关键词：DPP4 inhibitors ; 7-Oxopyrrolopyridines ; Atropisomers ; Diabetes mellitus

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2011

3.Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists

作者：Hao Zhang ; Denis E. Ryono ; Pratik Devasthale ; Wei Wang ; Kevin O’ ; Malley ; Dennis Farrelly ; Liqun Gu ; Thomas Harrity ; Michael Cap ; Cuixia Chu ; Kenneth Locke ; Litao Zhang ; Jonathan Lippy ; Lori Kuns

关键词：Dual PPAR α ; /γ ; agonists ; Azole ; Pyrrole ; Pyrazole ; Triazole ; Conformational constraint

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2009

4.Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

作者：Wei Wang ; Pratik Devasthale ; Dennis Farrelly ; Liqun Gu ; Thomas Harrity ; Michael Cap ; Cuixia Chu ; Lori Kunselman ; Nathan Morgan ; R ; y Ponticiello ; Rachel Zebo ; Litao Zhang ; Kenneth Locke ; Jonathan Lippy

关键词：PPAR ; Dual PPAR ; //www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">/γ ; agonists ; Antidiabetic azetidinones ; Boronic acid coupling ; Conformational constraint

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2008

5.Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

作者：Pratik V. Devasthale ; Sean Chen ; Yoon Jeon ; Fucheng Qu ; Denis E. Ryono ; Wei Wang ; Hao Zhang ; Lin Cheng ; Dennis Farrelly ; Rajasree Golla ; et al.

关键词：PPAR ; PPAR α ; /γ ; dual agonists ; Antidiabetic ; Oxybenzylglycines

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2007

6.Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta

作者：Hangeland ; Jon J. ; Doweyko ; Arthur M. ; Dejneka ; Tamara ; Friends ; Todd J. ; Devasthale ; Pratik ; et. al.

关键词：Thyromimetics ; Thyroid hormone receptor

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2004

7.Synthesis of conformationally constrained potential inhibitors of mammalian metalloproteinases

作者：Hanessian ; Stephen ; Griffin ; Andrew ; Devasthale ; Pratik V.

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1997

8.Synthesis of conformationally constrained potential inhibitors of mammalian metalloproteinases

作者：Hanessian ; Stephen ; Griffin ; Andrew ; Devasthale ; Pratik V.

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1997

9.Generation of Functional Diversity Via Nitroaldol Condensations of α-Aminoacid Aldehydes - A New and Stereocontrolled Route to Acyclic 1,3-Diamino-2-alcohols

作者：Hanessian ; Stephen ; Devasthale ; Pratik V.

刊名：Tetrahedron Letters

出版年：1996

10.Design and synthesis of novel, pseudo C2 symmetric inhibitors of HIV protease

作者：Hanessian ; Stephen ; Devasthale ; Pratik V.

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1996

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